Efeito da suplementação com goma guar no controle metabólico lipídico e glicídico e no índice de massa corporal em diabéticos do tipo 2
Palavras-chave:
índice de massa corporal, diabetes mellitus tipo 2, goma guar, controle metabólicoResumo
Objetivo
Avaliar os efeitos da suplementação de goma guar no controle metabólico e índice de massa corporal (IMC) em pacientes portadores de diabetes do tipo 2.
Métodos
Um total de dezessete participantes (doze mulheres e cinco homens) receberam a suplementação diária de dez gramas do suplemento de fibra durante três meses. Alterações no IMC e nos parâmetros bioquímicos (glicemia de jejum, hemoglobina glicada (HbA1c), colesterol plasmático total e triglicérides) foram avaliadas no início e ao final do estudo.
Resultados
Não foram verificadas alterações nos valores médios de IMC (p=0,770), glicemia de jejum (p=0,09) ou triglicérides (p=0,06). No entanto, foi observado aumento significativo (p<0,001) dos níveis de HbA1c após a ingestão dos suplementos de goma guar. Análise posterior indicou que cinco participantes que tiveram valores médios de glicemia de jejum e de HbA1c mais altos tiveram uma redução significativa (p=0,03) da glicemia de jejum ao final do estudo. Uma redução significativa (p<0,001) na concentração de colesterol total foi observada após os três meses de suplementação com a goma guar.
Conclusão
A suplementação dietética de goma guar (10g/dia) a pacientes portadores de diabetes tipo 2, com sobrepeso, proporcionando uma ingestão total de fibra próxima de 20g por dia, não foi efetiva para redução espontânea do peso corporal. Os efeitos da goma guar sobre o controle metabólico da glicose foram inconclusivos, mas mostrou ser uma estratégia dietética efetiva na redução dos níveis de colesterol sangüíneo.
Referências
King H, Aubert RE, Herman WH. Global burden of diabetes: estimates for 1997. CVD Prevention. 1998; 1:243-58.
King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998; 21(9):1414-31.
Malerbi DA, Franco LJ. Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30-69 yr. The Brazilian Cooperative Group on the Study of Diabetes Prevalence. Diabetes Care. 1992; 15(11):1509-16.
Ginsberg HN, Illingworth DR. Postprandial Dyslipidemia: an atherogenic disorder common in patients with diabetes mellitus. Am J Cardiol. 2001; 88(6A):9H-15H.
Gerstein HC, Anand S, Yi QL, Vuksan V, Lonn E, Teo K, et al. The relationship between dysglycemia and atherosclerosis in South Asian, Chinese, and European individuals in Canada: a randomly sampled cross- sectional study. Diabetes Care. 2003; 26(1):144-9.
Garg A. Treatment of diabetic dyslipidemia. Am J Cardiol. 1998; 81(4A):47B-51B.
American Diabetes Association. Translation of the diabetes nutrition recommendations for health care institutions (Position Statement). Diabetes Care. 2003; 26(Suppl 1):S70-S2.
Pontiroli AE. Type 2 diabetes mellitus is becoming the most common type of diabetes in school children. Acta Diabetol. 2004; 41(3):85-90.
Norris S, Zhang X, Avenell A, Gregg E, Schmid Ch, Lau J. Long-term non-pharmacological weight loss interventions for adults with prediabetes. Cochrane Database Syst Rev. 2005; 18(2):CD005270.
Poston WSC, Foreyt JP. Successful managment of the obese patient. Am Farm Physician. 2000; 61(12):3615-22.
Rogers PJ. Eating habits and appetite control: a psychobiological perspective. Proc Nutr Soc. 1999; 58(1):59-67.
Holt SHA, Brand-Miller JC, Stitt PA. The effects of equal-energy portions of different breads on blood glucose levels, feelings of fullness and subsequent food intake. Am Diet Assoc. 2001. 101(7): 767-73.
Blackburn NA, Holgate AM, Read NW. Does guar gum improve post-prandial hyperglycaemia in humans by reducing small intestinal contact ares? Br J Nutr. 1984; 52(20):197-204.
Giacco R, Parillo M, Rivellese AA, Lasorella G, Giacco A, D’Episcopo L, et al. Long-term dietary with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients. Diabetes Care. 2000; 23(10):1461-6.
Mcintosh M, Miller C. A diet containing food rich in soluble and insoluble fiber improves glycemic control and reduces hyperlipidemia among patients with type 2 diabetes mellitus. Nutr Rev. 2001; 59(2):52-5.
Spieth LE, Harnish JD, Lenders CM, Raezer LB, Pereira MA, Hangen SJ, et al. A low-glycemic index diet in the treatment of pediatric obesity. Arch Pediatr Adolesc Med. 2002; 154(9):947-51.
Ludwig DS, Majzoub JÁ, Al-Zahran A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999; 103(3):E26.
Anderson JW, Smith BM, Gustafson NJ. Health benefits and practical aspects of high-fiber diets. Am J Clin Nutr. 1994; 59(Suppl 5): 1242S-7S.
Ajani UA, Ford ES, Mokdad AH. Dietary fiber and C-reactive protein: findings from national health and nutrition examination survey data. J Nutr. 2004; 134(5):1181-5.
Schulze MB, Liu S, Rimm EB, Manson JE, Willett WC, Hu FB. Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr. 2004; 80(2):348-356.
Nutrition recommendation and principles for people with diabetes mellitus. Diabetes Care. 2000; 23(1):S43-S6.
Gerhardt AI, Gallo NB. Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. J Nutr. 1998; 128(5):865-9.
Blake DE, Hamblett CJ, Frost PG, Judd PA, Ellis PR. Wheat brad supplemented with depolimeried guar gum reduces the plasma cholesterol concentration in hypercholesterolemic human subjects. Am J Nutr. 1998; 65(1):882-90.
Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem. 2002; 48(3):436-72.
Bunn HF. Nonenzymatic glycosylation of protein: relevance to diabetes. Am J Med. 1981; 70(2): 325-30.
Bonora E, Calcaterra F, Lombardi S, Bonfante N, Formentini G, Bonadonna R, et al. Plasma glucose levels throughout the day and HbA1c interrelationships in type 2 diabetes: implications for treatment and monitoring of metabolic control. Diabetes Care. 2001; 24(12):2023-9.
Kirsten R, Heintz B, Nelson K, Oremek G, Speck U. Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus. Int J Clin Pharmacol Ther Toxicol. 1992; 30(12): 582-6.
Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care. 2003; 26(3): 881:5.
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Copyright (c) 2023 Mirela dos Santos Ourique FIGUEIREDO, Rita de Cássia Gonçalves ALFENAS, Sylvia do Carmo Castro FRANCESCHINI, Maria do Carmo Gouveia PELUZIO, Raquel Monteiro AZEREDO, Sônia Machado Rocha RIBEIRO
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