Suplementação de micronutrientes na senescência: implicações nos mecanismos imunológicos
Palabras clave:
envelhecimento, estado nutricional, micronutrientes, sistema imuneResumen
A prevalência de indivíduos idosos em detrimento de indivíduos jovens compreende um quadro comum na população mundial. As estimativas indicam que, em 2050, cerca de 22% da população mundial serão constituídos por indivíduos idosos. As mudanças no sistema imune do indivíduo idoso ocorrem acentuadamente na imunidade mediada por células, caracterizada pelo aumento do número de linfócitos T imaturos (CD2+CD3-), decréscimo do número de linfócitos T virgens (CD45RA), aumento dos linfócitos de memória (CD45RO), e aumento das células helper T2, com decréscimo das helper T1. Embora as mudanças na resposta humoral sejam menores no envelhecimento, a menor especificidade e afinidade dos anticorpos nos indivíduos idosos constituem uma diferenciação da resposta imune. Estudos recentes demonstram que no envelhecimento a suplementação de micronutrientes específicos exerce efeitos benéficos sobre o sistema imune.
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Derechos de autor 2023 Maria Rita Carvalho Garbi NOVAES, Marina Kyomi ITO, Sandra Fernandes ARRUDA, Polyana RODRIGUES, Adriana Queiroz LISBOA
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
