Micronutrients supplementation during the senescence: implications for the immunological functions

Authors

  • Maria Rita Carvalho Garbi NOVAES Universidade de Brasília
  • Marina Kyomi ITO Universidade de Brasília
  • Sandra Fernandes ARRUDA Universidade de Brasília
  • Polyana RODRIGUES Universidade de Brasília
  • Adriana Queiroz LISBOA Universidade de Brasília

Keywords:

aging, nutritional status, micronutrients, immune system

Abstract

The increase of the elderly population is a world-wide common phenomenon. According to some projections, in the year 2050, older people will constitute about 22% of the world population. Immune system deregulation in aging individuals is mainly a result of changes in cell mediated immunity, characterized by an increased number of immature T lymphocytes (CD2+CD3-), a decrease of T virgin lymphocytes (CD45RA), an increase of memory T lymphocytes (CD45RO), and by an increase in T helper 2 cells associated with a decrease in T helper 1 subset. Although changes in humoral immunity are less accentuated in the aging process, lower affinity for antigens and a narrower spectrum of the antibodies were observed in older people, as a dysfunction of immune response. Recent studies show that, in the aging, the supplementation of specific micronutrients is effective in restoring the normal immune response

References

Tinker A. The social implications of an aging population. Mech Aging Dev. 2002; 123(7): 729-35.

Goyns MH. The biology of aging. Mech Aging Dev. 2002; 123:727.

Duthie Jr EH, Katz PR. História e exame físico. 3. ed. In: Duthie Jr EH. Geriatria prática. Rio de Janeiro: Revinter; 2002.

Lesourd BM. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997; 66(2):S478-84.

High KP. Micronutrient supplementation and immune function in the elderly. Clin Infect Dis. 1999; 28(4):717-22.

Beaumont D, Lehmann AB, James OFW. Protein turnover in malnourished elderly subjects: the effects of referring. Age Ageing. 1989; 18(4): 235-40.

Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet. 1992; 340(8828):1124-7.

Krause D, Mastro AM, Handte G, Smiciklas-Wright H, Miles MP, Ahluwalia N. Immune function did not decline with aging in apparently healthy, well-nourished women. Mech Ageing Dev. 1999; 112(1):43-57.

Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev. 1984; 28(1):47-55.

Lesourd BM, Meaume S. Cell mediated immunity changes in ageing, relative importance of cell subpopulation switches and of nutritional factors. Immunol Lett. 1994; 40(30):235-42.

Mazari L, Lesourd BM. Nutritional influences on immune response in health aged persons. Mech Ageing Dev. 1998; 104(1):25-40.

Douek DC, Koup RA. Evidence for thymic function in the elderly. Vaccine. 2000; 18(16):1638-41.

Beverley PC, Grubeck-Loebenstein B. Is immune senescence reversible? Vaccine. 2000; 18(16): 1721-4.

Stacy S, Krolick KA, Infante AJ, Kraig E. Immunological memory and late onset autoimmunity. Mech Ageing Dev. 2002; 123(8):975-85.

Weksler ME. Changes in the B-cell repertoire with age. Vaccine. 2000; 18(16):1624-8.

Zhao KS, Wang YF, Gueret R, Weksler ME. Dysregulation of the humoral immune response in old mice. Int Immunol. 1995; 7(6):929-34.

Weksler ME, Goodhardt M. Do age-associated changes in “physiologic” autoantibodies contribute to infection, atherosclerosis, and Alzheimer’s disease? Exp Geront. 2002; 37(8-9): 971-9.

Nobrega A, Haury M, Gueret R, Coutinho A, Weksler ME. The age associated increase in autoreactive immunoglobulins reflects a quantitative increase in specifities detectable at lower concentrations in young mice. Scand J Immunol. 1996; 44(5):437-43.

Kemp FW, DeCandia J, Li W, Bruening K, Baker H, Rigassio D, et al. Relationships between immunity and dietary and serum antioxidants, trace metals, B vitamins, and homocysteine in elderly men and women. Nutr Res. 2002; 22:45-53.

Fraker JP, King LE, Laakko T, Vollmer TL. The dynamic link between the integrity of the immune system and zinc status. J Nutr. 2000; 130(5S Suppl):S1399-406.

Girodon F, Galan P, Monget A, Boutron-Ruault M, Brune-Lecomte P, Preziosi P, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized patients: a randomized controlled trial. Arch Intern

Med. 1999; 159(7):748-54.

Serafini M. Dietary vitamin E and T cell-mediated function in the elderly: effectiveness and mechanism of action. Int J Neurosc. 2000; 18 (4-5):401-10.

Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr. 1997; 66(2): S460-3.

Ravaglia G, Forti P, Mioli F, Bastagli L, Facchini A, Savarino L, et al. Effect of micronutrient status on natural killer cell imune function in healthy free-living subjects aged ≥90 y. Am J Clin Nutr. 2000; 71(2):590-8.

Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial. JAMA. 1997; 277(7):1380-6.

Meydani SN, Barklund PM, Liu S, Meydani M, Miller RA, Cannon JC, et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr. 1990; 52(3):557-63.

De Waart FG, Portengen L, Doekes G, Verwaal DJ, Kok FJ. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects. Br J Nutr. 1997; 78(5):761-74.

Pallast EG, Schouten EG, Waart FG, Fonk HC, Doekes G, Mary von Blomberg B, et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in no institutionalized elderly persons. Am J Clin Nutr. 1999; 69(6):1273-81.

De la Fuente M, Ferrández MD, Burgos MS, Soler A, Prieto A, Miquel J. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol. 1998; 76(4): 373-80.

Boukaiba N, Flament C, Acher S. A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am J Clin Nutr. 1993; 57(4):566-72.

Mocchegiani E, Muzzioli M, Giacconi R. Zinc and immunoresistance to infection in aging: new biological tools. Trends Pharmacol Sci. 2000; 21(6):205-8.

FUNCOR. Alimentação na terceira idade. Rev Nutrição. 2002; 1(14):28-30.

Shankar AH, Prasad AS. Zinc and immune fuction: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998; 68(2 Suppl): S447-63.

Gardner EM, Bernstein ED, Popoff KA, Abrutyn E, Gross P, Murasko DM. Immune response to influenza vaccine in healthy elderly: lack of association with plasma β-carotene, retinol, α-tocopherol, or zinc. Mech Ageing Dev. 2000; 117(1-3):29-45.

Fata FT, Herzlich BC, Schiffman G, Ast AL. Impaired antibody responses to pneumococcal polysaccharide in elderly patients with low serum vitamin B sub 12 levels. Ann Int Med. 1996; 124(3): 299-304.

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Published

2023-09-22

How to Cite

Carvalho Garbi NOVAES, M. R. ., Kyomi ITO, M., Fernandes ARRUDA, S., RODRIGUES, P. ., & Queiroz LISBOA, A. . (2023). Micronutrients supplementation during the senescence: implications for the immunological functions. Brazilian Journal of Nutrition, 18(3). Retrieved from https://periodicos.puc-campinas.edu.br/nutricao/article/view/9838

Issue

Vol. 18 No. 3 (2005): Revista de Nutrição

Section

Comunicação

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Copyright (c) 2023 Maria Rita Carvalho Garbi NOVAES, Marina Kyomi ITO, Sandra Fernandes ARRUDA, Polyana RODRIGUES, Adriana Queiroz LISBOA

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