EFEITO DA INGESTÃO DE ÁLCOOL DURANTE A LACTAÇÃO SOBRE A PRODUÇÃO E COMPOSIÇÃO DO LEITE MATERNO E SOBRE O CRESCIMENTO DA PROLE: ESTUDO EM RATAS
Keywords:
lactação, animais lactentes, álcool etílico, crescimento, leite, ratos de cepas endogâmicas, síndrome alcóolica fetalAbstract
The possibility that maternal ingestion of alcohol during lactation could affect milk production and composition and could impair neonatal growth was explored. Lactating rats fed with 20% of ethanol during lactation and respective progeny (AL) were com pared with control animais (C). AII animais were killed on the 12th day of lactation. ln the AL dams, food intake decreased determining a significantly lower body weight when compared with controls. Alcohol ingestion during lactation caused a reduction of daily milk production and its composition was significantly lower in carbohydrate, while the lipid and protein contents were similar to those of control dams. Progeny of alcoholic mothers showed a reduced growth and a noticeable malnutrition when compared with progeny of control mothers. These data showed that the ethanol consumption during lactation altered milk production and composition, which, in turn, were associated with retarded postnatal growth and development.
References
BERLIN, C. M. Pharmacologic considerations of drug use in the lactating mother. Obstetrics and Gynecology, New York, v. 58, n.5, p.17S-23S, 1981.
BUCOLO, G. & DAVID, H. Quantitative d6termination of serum triglycerides by the use of enzymes. Clinicai Chemistry, Winston Salem, v.19, n. 5, p.476-482, 1973.
COBO, E. Effect of different doses of ethanol on the milk ejecting reflex in lactating woman. American Journal of Obstetrics Gynecology, St. Louis, v. 115, n. 6, p. 817-821, 1973.
COWARD, W. A.; COLE, T. J.; GERBER, H.; ROBERT$, S. B. & FLEET, 1. Water turnover and the measurement of milk intake. Ptlügers Archiv, Berlin, v. 393, n. 4, p. 344-347, 1982.
DUBOIS, M.;GILLES, K.A.;HAMILTON,J.K;REBERS,P. A. &SMITH, F. Colorimetric method for determination of sugars and related substances. Analytical Chemistry, Washington, DC, v. 28, n. 3, p. 350-556, 1956.
JASON, J. Breast-feeding in 1991. New England Journal of Medi cine, Boston, v. 325, n.14, p.1036-1038, 1991.
JONES, K. L.; SMITH, D. W.; ULLELAND, C. N. & STREISSGUTH, P.P. Pattern of malformation in offspring of chronic alcoholic mothers. Lancet, London, v.1, n.815, p.1267-1271, 1973.
KAMINSKI, M.; RUMEAU, C. & SCHWARTZ, D. Alcohol consumption in pregnant women and the outcome of pregnancy. Alcoholism: Clinica! and Experimental Research, Baltimore, V. 2, n. 2, p.155-163, 1978.
KEEN, C. L.; LONNERDAL, B.; CLEGG, M. & HURLEY, L. Developmental changes in composition of rat milk: trace ele ments, minerais protein, carboydrate and fat. Journal of Nutri tion, Bethesda, v. 111, n. 2, p. 226-230, 1981.
KESANEIMI, Y. A. Ethanol and acetaldehyde in the milk and peripheral blood of lactating women aftet ethanol administration. Journal of Obstetrics and Gynaecology British Common wealth, London, v. 81, n. 1, p. 84-86, 1974.
RANDALL, C. L.; EKBLAD, U. & ANTON, R. F. Perspective on the pathophysiology of fetal alcohol syndrome. Alcoholism: Clinica! and Experimental Research, Baltimores, v. 14, n. 6, p. 807-812, 1990.
ROBINSON, A. M. & WILLIAMSON, D. H. Comparison of glucose metabolism in the lactating mammary ofthe rat in vivo and in vitro: effects of starvation, prolactin or insulin eficiency. Biochemical Journal, London, v. 164, n.1, p. 153-159, 1977.
RUSSEL, J. A. Milk yield, suckling behavior and milk ejection in the lactating rat nursing litters of different sizes. Journal of Physiology, Cambridge, v. 303, p. 403-415, 1980.
SCOW, R. O.; HAMOSH, M.; BLANCHETTE-MACKIE, E. J. & EVANS, A. J. Uptake of blood triglyceride by various tissues. Lipids, Illinois, v. 7, n. 8, p. 497-505, 1972.
TAVARES-DO-CARMO, M. G. Efeito da ingestão de álcool sobre o metabolismo lipídico em ratas lactantes. São Paulo: Escola Paulista de Medicina, 1993. 169p. Tese (Doutorado em Ciên cias) - Escola Paulista de Medicina, 1993.
& NASCIMENTO-CURI, C. M. O. Effect of ethanol intake during lactation on the metabolism of dams and on pup development. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 23, n.11, p.1161-1163, 1990.
; ANDRADE, 1. S.; HIRATA, A. E. & NASCI MENTO-CURI, C. M. O. Efeito da ingestão de etanol durante a lactação sobre a lipogênese da glândula mamária "in vitro". ln: REUNIÃO ANUAL DA FEDERAÇÃO DE SOCIEDADES DE BIOLOGIA EXPERIMENTAL, 8., agosto de 1993, Caxambu. Anais... Caxambu: Sociedade Brasileira de Bioquímica e Biologia Molecular e de Imunologia, 1983. p.157. (Resumos 5.3).
TESTAR, X.; LOPEZ, D.; LLOBERA, M. & HERRERA, E. Ethanol administration in the drinking fluid to pregnant rats as a model for the fetal alcohol syndrome. Pharmacology Biochemistry and Behavior, Elmsford, v. 24, n. 3, p. 625-630, 1986.
; LLOBERA, M. & HERRERA, E. Comparative metabolic effects of chronic ethanol intake and undernutrition in pregnant rats and their fetuses. Alcoholism: Clinica! and Experi mental Research, Baltimore v. 12, n. 2, p.197-200, 1988.
VILARO, S.; VINAS, O.; REMESAR, X.; HERRERA, E. Effects of chronic ethanol consumption on lactational performance in rat: mammary gland and milk composition and pups growth and metabolism. Pharmacology Biochemistry and Behavior, Elmsford, v. 27, n. 2, p. 333-339, 1987.
WIENER, S. G.; SHOEMAKER, W. J.; KODA, L. Y. & BLOOM, E. lnteraction of ethanol and nutrition during gestation: influence on maternal and offspring development in the rat. Journal of Phar macology and Experimental Therapeutics, Baltimore, v. 216, n. 6, p. 572-579, 1981.
WILLIAMSON, D.H. lntegration of metabolism in tissues of the lactating rat. Federation of European Biochemical Societies, Amsterdam, v. 117S, p. K93-K105, 1980.
_____- ;MUNDAY, M. R. & JONES, R. J. Biochemical basisofdietary influences on the synthesis of macronutrients of rat milk. Federation Proceedings, Baltimore, v. 43, n. 9, p. 2443-2447, 1984.
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