Whey protein: composition, nutritional properties, appications in sports and benefits for human health
Keywords:
food, fortified, exercise, milk proteins, dietary supplementsAbstract
The soluble proteins of milk, also known as whey protein, are extracted during the cheese manufacturing process. They have high nutritional value, with high levels of essential amino acids, especially branched chain amino acids. They also have a high level of calcium and whey bioactive peptides. Recent researches have shown their wide application for sports with possible effects on skeletal muscle protein synthesis, reduction of body fat, as well as adiposity modulation, and improved muscle performance. Researches involving the analysis of their bioactive compounds have also shown benefits to human health. Among these benefits, their hypotensive, antioxidant, and hypocholesterolemic effects stand out. This review has searched scientific articles that evaluate the functional properties of whey protein, both in humans and animals. Despite this evidence, new researches, as well as the development of new whey protein-enriched foods to increase their consumption by the population, are necessary to check their real effectiveness.
References
Salzano Jr I. Nutritional supplements: practical applications in sports, human performance and life extension. Symposium series 007; São Paulo; 1996-2002. p.75-202.
Groziak SM, Miller GD. Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system. Brit J Nutr. 2000; 84(6):119-25.
Lönnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr. 2003; 77(6):1537-43.
Kinsella JE, Whitehead DM. Proteins in whey: chemical, physical and functional properties. Adv Foods Nutr Res. 1989; 33:343-438.
De Wit JN. Nutritional and functional characteristics if whey proteins in foods products. J Dairy Sci. 1998; 81(3):597-608.
Aimutis WL. Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr. 2004; 134(4):989s-95s.
Shannon LK, Chatterton D, Nielsen K, Lönnerdal B. Glycomacropeptide and alfa-lactoalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr. 2003; 77(5):1261-8.
Markus CR, Oliver B, DE Haan EHF. Whey Protein rich in alfa-lactoalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002; 75(6):1051-6.
Ha E, Zemel MB. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people. J Nutr Biochem. 2003; 14(5):251-58.
Etzel MR. Manufacture and use of dairy protein fractions. J Nutr. 2004; 134(4):996s-1002s.
Phillips SM, Tipton KD, Ferrando AA, Wolfe RR. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol End Met. 1999; 276(1):E118-24.
Yarasheski KE, Pak-Loduca J, Hasten DL, Obert KA, Brown MB, Sinacore DR. Resistance exercise training increases mixed muscle protein synthesis rate in frail woman and men >76 yr old. Am J Physiol. 1999; 277(1):E118-25.
Hasten DL, Pak-Loduca J, Obert KA, Yarasheski KE. Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yrs old. Am J Physiol End Met. 2000; 278(4):E620-6.
Lemon PWR. Effects of exercise on dietary protein requirements. Int J Sports Nutr. 1998; 8(4): 426-47.
Ivy JL, Goforth Jr HW, Damon BM, McCauley TR, Parsons EC, Price TB. Early postexercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement. J Appl Physiol. 2002; 93(4):1337-44.
Børshein E, Aarsland A, Wolfe, RR. Effect of an amino acids, protein, and carbohydrate mixture in net muscle protein balance after resistance exercise. Int J Sports Nutr Exer Metab. 2004; 14(3):255-71.
Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M. Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. J Physiol. 2001; 535(1):301-11.
Wolfe RR. Protein supplements and exercise. Am J Clin Nutr. 2000; 72(2):551s-7s.
Kimball SC. Regulation of global and specific mRNA translation by amino acids. J Nutr. 2002; 132(5):883-6.
Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translation control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001; 131(3):856s-60s.
van Loon LJC, Saris WHM, Verhagen H, Wagenmakers JM. Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr. 2000; 72(1):96-105.
Burke DG, Chilibeck PD, Davison KS, Candow DG, Farthing J, Smith-Palmer T. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sports Nutr Exe Met. 2001; 11(3):349-64.
Dangin M, Boirie Y, Garcia-Rodenas C, Gachon P, Fauquant J, Callier P, et al. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol End Met. 2001; 280(2):E340-E8.
Zawadzki KM, Yaspelkis BB III, Ivy JL. Carbohydrate-protein complex increased the rate of muscle glycogen storage after exercise. J Appl Physiol. 1992; 72(5):1854-9.
Calbet JAL, MacLean DA. Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans. J Nutr. 2002; 132(8):2174-82.
Werustsky CA. Inibição da degradação protéica muscular em atletas pela suplementação de aminoácidos. Nutrição Enteral e Esportiva. Rio de Janeiro; 1993. 6:4-7.
Popkin BM. The nutrition transition and its health implications in lower-income countries. Publ Health Nutr. 1998; 1(1):5-21.
Fontaine KR, Faith MS, Allison DB, Cheskin LJ. Body weight and health care among woman in the general population. Arch Farm Med. 1998; 7(4):381-4.
Zemel MA. Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr. 2004; 79(5):907s-12s.
Layman DK. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. 2003; 133(1): 261-7.
Layman DK, Baum JI. Dietary protein impact on glycemic control during weight loss. J Nutr. 2004; 134(4):968s-73s.
Layman DK, Shiue H, Sather C, Erickson D, Baum J. Increased dietary protein modifies glucose and insulin homeostasis in adult woman during weight loss. J Nutr. 2003; 133(2):405-10.
Bouthegourd JCJ, Roseau SM, Makarios-Lahhan L, Leruyet PM, Tomé DG, Even PC. A preeexercise alfa-lactalbumin-enriched whey protein meal preserves lipid oxidation and decreases adiposity in rats. Am J Physiol End Met. 2002; 283(3): E565-E72.
Graaf C, Blom WAM, Smeets AM, Stafleu A, Hendriks FJ. Biomarkers of satiation and satiety. Am J Clin Nutr. 2004; 79(6):946-61.
Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acids profiles, gastrointestinal hormone secretion and appetite. Brit J Nutr. 2003; 89(2):239-48.
Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration and adaptation. Physiol Rev. 2000; 80(3):1055-81.
Lands LC, Grey VL, Smoutas AA. Effect of supplementation with cysteine donor on muscular performance. J Appl Physiol. 1999; 87(4):1381-5.
Toba Y, Takada, Y, Matsuoka Y, Morita Y, Motouri M, Iría T, et al. Milk basic protein promotes bone formation and suppresses bone resorption in health adult men. Biosci Biotechnol Biochem. 2001; 65(4):1353-57.
Fitzgerlad RJ, Murray BA, Walsh DJ. Hypotensive peptides from milk protein. J Nutr. 2004; 134(4):980s-8s.
Pins JJ, Keenan JM. The effects of a hydrolyzed whey protein supplement (Biozate® 1) on ACE activity and bradykinin. In: Proceeding of 64th Annual Scientific Sessions of the American Diabetes Association 2004; Orlando, Florida.
Kawase M, Hashimota H, Hosoda M, Morita H, Hosono A. Effects of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci. 2000; 83(2):255-63.
Markus CR, Oliver, B, Panhuysen GEM, der Gusten JV, Alles MS, Tuiten A, et al. The bovine protein alfa-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr. 2000; 71(6):1536-44.
Rossi L, Tirapegui J. Aspectos atuais sobre exercício físico, fadiga e nutrição. Rev Paul Educ Fis. 1999; 13(1):67-82.
Lönnerdal B. Dietary factors influencing zinc absorption. J Nutr. 2000; 130(5):1378s-83s.
Borges PFZ. Produção de concentrados de proteínas de leite bovino: composição e valor nutritivo. Braz J Food Tecnol. 2001; 4(1):1-8.
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