Effect of conjugated linoleic acid supplementation and swimming training on the body composition and biochemical parameters of Wistar pups
Keywords:
Linoleic acid, Experimental studies, Swimming, RatsAbstract
Objective
The objective of this study was to evaluate the effects of conjugated linoleic acid supplementation associated with moderate swimming training on body composition, food efficiency and consumption, blood glucose, lipid profile, and muscle and liver glycogen of Wistar rats.
Methods
Thirty-day old Wistar rats were divided into the following groups: inactive, inactive with 2% conjugated linoleic acid supplementation, active, and active with 2% conjugated linoleic acid supplementation. They remained in individual cages with food and water ad libitum, temperature of 23±1ºC and a light and dark cycle of 12 hours for 8 weeks. The active groups swam for one hour three times per week. The animals were killed and the plasma, white and brown fat tissues, gastrocnemius muscle and liver were collected and weighted.
Results
Supplementation per se did not promote food intake or body weight changes in the animals. Fasting glucose (p<0.05) and high density lipoproteins (HDL, p<0.05) increased and triacylglycerols decreased. Supplementation associated with activity decreased body mass (p<0.05) and increased the relative weight of fat tissues, liver and fasting glucose.
Conclusion
Conjugated linoleic acid supplementation associated with physical activity seems to influence energy balance. On the other hand, the increased liver weight indicates that intake of this fatty acid may have undesirable sideeffects, increasing the chances of developing fatty liver. This new perspective makes way for new studies including histological analyses of the liver and gene expression of key enzymes from the lipid and carbohydrate metabolism, associated or not with different physical training protocols.
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Copyright (c) 2023 Antonio Eduardo de AQUINO JUNIOR, Grace Kelly Zanotti Simões DOURADO, Fernanda Oliveira DUARTE, Ana Cláudia Garcia Oliveira DUARTE, Marcela SENE-FIORESE
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