High-protein diet for body weight loss

Authors

  • Rogerio Graça PEDROSA Universidade de São Paulo
  • Jose DONATO JUNIOR Universidade de São Paulo
  • Julio TIRAPEGUI Universidade de São Paulo

Keywords:

Body composition, Weight loss, Dietary proteins

Abstract

The ideal proportion of macronutrients in weight loss diets is currently under debate. There are evidences indicating that a higher proportion of protein during weight loss diets enhances the loss of body weight and fat mass, and reduces the loss of lean body mass. Nevertheless, the responsible mechanisms for these effects have not yet been fully elucidated. Furthermore, studies that evaluated the possible side effects of these diets on the renal function and on the nutritional state of calcium have shown inconclusive results. Therefore, this article has the objective to convey recent information about the effects of high-protein
diets in the regulation of the body weight and body composition, besides its involved mechanisms, and its effects on the renal function and on the calcium nutritional status. 

References

Kopelman PG. Obesity as a medical problem. Nature. 2000; 404(6778):635-43.

Pi-Sunyer FX. Obesity: criteria and classification. [Symposium on ‘Body weight regulation and obesity: metabolic and clinical aspects’ 1st Plenary Session: ‘Obesity’]. Proc Nutr Soc. 2000; 59(4): 505-9.

Expert Panel on the Identification, Evolution, and Treatment of Overweight in Adults. Clinical guidelines on the identification, evolution, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr. 1998; 68(4): 899-917.

Fujioka K. Management of obesity as a chronic disease: nonpharmacologic, pharmacologic, and surgical options. Obes Res. 2002; 10(Suppl 2): 116-23.

Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr. 1995; 49(1):1-10.

Distschuneit HH, Flechtnes-Mors M, Johnson TD, Adler G. Metabolic and weight-loss effects of a long-term dietary intervention in obese patients. Am J Clin Nutr. 1999; 69(2):198-204.

Skov AR, Toubro S, Ronn B, Holm L, Astrup A. Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes. 1999; 23(5):558-36.

Layman DK, Boileau RA, Erickson DJ, Painter JE, Shiue H, Sather C, et al. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr. 2003; 133(2): 411-7.

Farnsworth E, Luscombe ND, Noakes M, Wittert G, Argyiou E, Clifton PM. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin Nutr. 2003; 78(1):31-9.

Layman DK, Evans E, Baum JI, Seyler J, Erickson DJ, Boileau RA. Dietary protein and exercise have additive effects on body composition during weight loss in adult women. J Nutr 2005; 135(8): 1903-10.

Eisenstein J, Roberts SB, Dallal G, Saltzman E. High-protein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data. Nutr Rev. 2002; 60(7 Pt 1): 189-200.

Halton TL, Hu FB. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr. 2004; 23:373-85.

Buchholz AC, Schoeller DA. Is calorie a calorie? Am J Clin Nutr. 2004; 79(5):899-906.

Johnston CS, Tjonn SL, Swan PD. High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults. J Nutr. 2004; 134(3):586-91.

Lacroix M, Gaudichon C, Martin A, Morens C, Mathé V, Tomé D, et al. A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats. Am J Physiol Regul Integr Comp Physiol. 2004; 287(4):934-42.

Noakes M, Keogh JB, Foster PR, Clifton PM. Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutrition status, and markers of cardiovascular health in obese women. Am J Clin Nutr. 2005; 81(6):1298-306.

Poehlman ET, Horton ES. The impact of food intake and exercise on energy expenditure. Nutr Rev. 1989; 47(5):129-37.

Westerterp KR, Wilson SAJ, Rolland V. Diet induced thermogenesis over 24h in a respiration chamber: effect of diet composition. Int J Obes. 1999; 23(3):287-92.

Robinson SM, Jaccard C, Persaud C, Jackson AA, Jequier E, Schutz Y. Protein turnover and thermogenesis in response to high-protein and high-carbohydrate feeding in men. Am J Clin Nutr. 1990; 52(1):72-80.

Layman KL. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. 2003; 133(1): 261-7.

Layman KL, Walter DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006; 136(1 Suppl):319-23.

Tom A, Nair KS. Assessment of branched-chain amino acid status and potential for biomarkers. J Nutr. 2006; 136(1 Suppl):324-30.

Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Bidirectional modulation of insulin action by amino acids. J Clin Invest. 1998; 101(7):1519-29.

Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001; 131(3):856-60.

Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am J Physiol Endocrinol Metab. 2002; 283(3): 503-13.

Millward DJ, Waterlow JC. Effect of nutrition on protein turnover in skeletal muscle. Fed Proc. 1978; 37(9):2283-90.

Ventrucci G, Silva LGR, Mello MAR, Marcondes MCG. Effects of a leucine-rich diet on body composition during nutritional recovery in rats. Nutrition. 2004; 20(2):213-7.

Donato Jr J, Pedrosa RG, Vinicius F, Cruzat VF, Pires ISO, Tirapegui J. Effects of chronic leucine supplementation on the body composition and protein nutritional status of adult rats submitted to food restriction. Nutrition. 2006; 22(5):520-27.

Mourier A, Gautier JF, Kerviler E, Bigard AX, Villette JM, Garnier JP, et al. Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements. Diabetes Care. 1997; 20(30):385-91.

Published

2023-08-30

How to Cite

Graça PEDROSA, R. ., DONATO JUNIOR, J. ., & TIRAPEGUI, J. . (2023). High-protein diet for body weight loss. Brazilian Journal of Nutrition, 22(1). Retrieved from https://periodicos.puc-campinas.edu.br/nutricao/article/view/9462