Effect of a commercial enteral diet with added antioxidants on total plasma thiol, protein carbonyl and malondialdehyde levels after a stroke

Authors

  • Lorene Simioni YASSIN Nutricionistas
  • Chika FUKUI Nutricionista
  • Pamela Cristiani Dias PEREIRA Nutricionista
  • Marcia OLANDOSKI Pontifícia Universidade Católica do Paraná
  • Paulo Roberto AVELES Pontifícia Universidade Católica do Paraná
  • Silvia Carolina PINTO Pontifícia Universidade Católica do Paraná
  • Caroline RESNAUER Nutricionista
  • Lia Sumie NAKAO Pontifícia Universidade Católica do Paraná
  • Ivone Ikeda MORIMOTO Pontifícia Universidade Católica do Paraná

Keywords:

Cerebrovascular accident, Carbonyl stress, Lipid peroxidation, Supplementary feeding, Nutrition therapy

Abstract

Objective
The aim of this study was to assess the effect of a commercial enteral diet with added antioxidants on total plasma thiol, protein carbonyl and malondialdehyde levels of stroke survivors.

Methods
Fourteen patients from a general hospital who had been started on enteral nutrition 48 hours after a stroke were included in the study. The exclusion criteria were multiple organ dysfunction syndrome, liver failure and morbid obesity associated with diabetes Mellitus. The commercial diet was fed by continuous drip via infusion pump and contained mixed carotenoids, vitamins C and E, and the minerals selenium, zinc and copper. Blood samples were collected at baseline and after 5 days of enteral diet, but only from patients whose diet intake met their total energy expenditure. Total plasma thiol and protein carbonyl levels were determined by Ellman’s reagent and dinitrophenylhydrazine, respectively. Plasma malondialdehyde levels were measured by the assay
of thiobarbituric acid reactive substances.

Results
The mean age of the sample was M=70.3 years, (SD=14.1). All patients received more than 100% of the Dietary Reference Intakes for the abovementioned antioxidants but none exceeded the tolerable upper limit. Plasma thiol and malondialdehyde levels did not vary over time but protein carbonyl levels were significantly higher (p=0.034), especially in intubated patients (p=0.048).

Conclusion
Biomarker determinations showed that a commercial enteral diet with added antioxidants did not reduce oxidative stress.

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Published

2023-08-17

How to Cite

Simioni YASSIN, L., FUKUI, C. ., Dias PEREIRA, P. C. ., OLANDOSKI, M. ., AVELES, P. R., PINTO, S. C., … Ikeda MORIMOTO, I. (2023). Effect of a commercial enteral diet with added antioxidants on total plasma thiol, protein carbonyl and malondialdehyde levels after a stroke. Brazilian Journal of Nutrition, 25(2). Retrieved from https://periodicos.puc-campinas.edu.br/nutricao/article/view/9241

Issue

Vol. 25 No. 2 (2012): Revista de Nutrição

Section

ORIGINAL ARTICLE

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Copyright (c) 2023 Lorene Simioni YASSIN, Chika FUKUI, Pamela Cristiani Dias PEREIRA, Marcia OLANDOSKI, Paulo Roberto AVELES, Silvia Carolina PINTO, Caroline RESNAUER, Lia Sumie NAKAO, Ivone Ikeda MORIMOTO

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