Effects of the flavonoid quercetin and the natural dyes bixin and norbixin on blood parameters of rabbits
Keywords:
quercetin, bixin, norbixin, metabolism, New Zealand rabbits, cholesterol, lipoproteins, HDL-cholesterol, urea, favonesAbstract
The objective of this study was to evaluate the therapeutic action of quercetin, bixin and norbixin, in the daily dose of 0,01mol/kg, in hyperlipidemic rabbits induced by cholesterol at 0.5% and colic acid at 0.1%, during the period of twenty-eight days, after which they were anesthetized and samples of blood were collected, in order to determine cholesterol, HDL-cholesterol, triacylglycerols, urea, creatinine, uric acid, total proteins, calcium, aspartate aminotransferase and alanine aminotransferase. These researchs are important to verify the effects of flavonoids and natural dyes on the metabolism of these constituents, in order to study hepatic or
renal disorders. The results showed that cholesterol was reduced by bixin (-44.03%) and by quercetin (-35.07%), while the association reduced urea in 5.73%. None of the constituents analyzed in this study presented deleterious effects and it was not possible to demonstrate the innocuity of these compounds.
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