Creatine as an ergogenic supplement for athletes
Keywords:
creatine, supplementary feeding, metabolism, exerciseAbstract
Several researches on creatine have been done due to its potential effects on the physical performance of athletes involved in high intensity, short duration and intermittent exercises with short periods of recovery. Phosphorylated creatine is an energy reserve in the muscle cells. During an intense exercise, its breakdown liberates energy used to regenerate adenosine triphosphate. Approximately 95% of the creatine pool is found in the skeletal muscle, and the regenerating process after exercise is oxygen dependent. Studies show that supplementation with this compound may procedure an increase of 10% to 20% in the organic pool, and this percentage is higher in vegetarian athletes (up to 60%). There is still controversy regarding the benefits and risks of supplementation with this substance. This paper reviews some aspects related to the creatine metabolism and its use as an ergogenic substance in sports practice.
References
AMERICAN COLLEGE OF SPORTS MEDICINE. The physiological and health effects of oral creatine supplementation. Medicine and Science in Sports and Exercise, Madison, v.32, n.3, p.706-717, 1999.
BALSOM, P., SODERLUND, K., EKBLOM, B. Creatine in humans with special reference to creatine supplementation. Sports Medicine, Auckland, v.18, n.4, p.268-280, 1994.
BALSOM, P., SODERLUND, K., SJODIN, B., EKBLOM, B. Skeletal muscle metabolism during short duration high intensity exercise: influence of creatine supplementation. Acta Physiologica Scandinavica, Stockholm, v.154, n.3, p.303-310, 1995.
BROBERG, S., SAHLIN, K. Adenine nucleotide degradation in human skeletal muscle during prolonged exercise. Journal of Applied Physiology, Bethesda, v.67, n.1, p.116-122, 1989.
BURKE, E., BERNING, J. Nutritional ergogenics aids. In: BURKE, E., BERNING, J. Training nutrition. Carmel : Cooper P.G., 1996. p.94-96.
DAWSON, B., CUTLER, M., MOODY, A., LAWRENCE, S., GOODMAN, C., RANDALL, N. Effect of oral creatine loading on single and repeated maximal shorts sprints. Australian Journal of Science Medicine Sports, Camberra, v.27, n.3, p.56-61, 1995.
DEVLIN, T. Textbook of biochemistry: with clinical correlations. New York : Wiley-Liss, 1992. 518p.
EDSTRÖM, L., HULTMAN, E., SAHLIN, K. The contents of high-energy phosphates in different fiber types in skeletal muscles from rat, guinea pig and man. Journal of Physiology, Masson, v.332, p.47-58, 1982.
FORBES, G. Composición del organismo. In: ORGANIZACIÓN MUNDIAL DE LA SALUD. Conocimientos actuales de nutrición. 6.ed. Washington : [s.n.], 1991. p.57-68. (Publicación Científica, n.532).
GARIOD, L., BINZONI, T., FERETTI, G. Standardization of 31 phosphorus-nuclear magnetic resonance spectroscopy determinations of high-energy phosphates in humans. European Journal of Applied Physiology, Berlin, v.68, n.2, p.107-110, 1994.
GREEN, A.L., SIMPSOM, E.S., LITTLEWOOD, J.S., MacDONALD, I.A., GREENHAFF, P.L. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiologica Scandinavica, Stockholm, v.158, n.2, p.195-202, 1996.
GREENHAFF, P., BODIN, K., HARRIS, R., HULTMAN, E., JONES, D.D., McINTYRE, D. The influence of oral creatine supplementation on muscle creatine resynthesis following intense contraction in man. Journal of Physiology, Masson, v.467, p.75, 1993. (Abstract).
GREENHAFF, P.L., NEVILL, M.E., SODERLUND, K., BODIN, K., BOOBIS, L.H., WILLIAMS, C., HULTNAN, E. The metabolic response of human type I and II muscles fibers during maximal treadmill sprinting. Journal of Physiology, Masson, v.478 (Parte 1), p.149-155, 1994.
GREENHAFF, P.L. Creatine and its application as an ergogenic aid. International Journal of Sports Nutrition, Sttutgart, v.5, p.S100-S110, 1995. Supplement.
GREENHAFF, P. The nutritional biochemistry of creatine. Journal of Nutritional Biochemistry, Stoneham, v.11, p.610-618, 1997.
GRINDSTAFF, P., KREIDER, R., BISHOP, R., WILSON, M., WOOD, L., ALEXANDER, C., ALMADA, A. Effects of creatine supplementation on repetitive sprint performance and body composition in competitive swimmers. International Journal of Sports Nutrition, Sttutgart, v.7, n.4, p.330-346, 1997.
GUERRERO-ONTIVEROS, M.L., WALLIMANN, T. Creatine supplementation in health and disease of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscles. Molecular and celular Biochemistry, Washington, v.184, n.1/2, p.427-437, 1998.
HARRIS, R.C., SODERLUND, K., HULTMAN, E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clinical Science, Colchester, v.83, n.3, p.367-374, 1992.
HOUSTON, M. Biochemical energetics. In: HOUSTON, M. Biochemistry primer for exercise science. Champaign : Human Kinetics, 1995. p.49-56.
HULTMAN, E., SODERLUND, K., TIMMONS, J.A., CEDERBLAD, G., GREENHAFF, P.L. Muscle creatine loading in men. Journal of Applied Physiology, Bethesda, v.81, n.1, p.232-237, 1996.
KREIDER, R. Creatine, the next ergogenic supplement? Disponível em: http://www.sportsci.org/traintech/creatine/rbk.html>. Acesso em: 1998.
McCULLY, K., POSNER, J. Measuring exercise-induced adaptations and injury with magnetic resonance spectroscopy. International Journal of Sports Medicine, Sttutgart, v.13, p.S147-S149, 1992. Supplement 1.
MAYES, P. The respiration chain and oxidative phosphorylation. In: MURRAY, R., GRANNER, D., MAYES, P., RODWELL, V. (Ed.). Harper’s
biochemistry. 24.ed. Stamford : Lange, 1996. p.123-134.
MOLLER, P., BERGSTROM, J., FURST, P. Effect of aging on energy rich phosphagens in human skeletal muscles. Clinical Science, Colchester, v.58, n.6, p.553-555, 1980.
MOLLER, P., BRANDT, R. Skeletal muscle adaptation to aging and to respiratory and liver failure. Stockholm, 1981. (Dissertation) - Karolinska Institute, 1981.
NEWSHOLME, E., LEECH, T., DEUSTER, G. Keep on running. Chichester : John Wiley & Sons., 1994. p.50-69.
ODOOM, J.E., KEMP, G.J., RADDA, G.K. The regulation of total creatine content in amyoblast cell line. Molecular and Celular Biochemistry, Washington DC, v.158, n.2, p.179-188, 1996.
POORTMANS, J.R., AUQUIER, H., RENAUT, V., DURASSEL, A., SAUGY, M., BRISSON, G.R. Effect of short-term creatine supplementation on renal responses in men. European Journal of Applied Physiology, Berlin, v.76, n.6, p.566-567, 1997.
REDONDO, D.R., DOWLING, E.A., GRAHAM, B.L., ALMADA, A.L., WILLIAMS, M.H. The effect of oral creatine monohydrate supplementation on running velocity. International Journal of Sports Nutrition, Sttutgart, v.6, n.3, p.213-221, 1996.
RODWELL, V. Conversion of aminoacids to specialized products. In: MURRAY, R., GRANNER, D., MAYES, P., RODWELL, V. (Ed.). Harper’s biochemistry. 24.ed. Stamford : Lange, 1996. p.341-362.
SMITH, S., MONTAIN, S., MATOTT, R., ZIENTARA, G., JOLESZ, F., FIELDING, R. Creatine supplementation and age influence muscle metabolism during exercise. Journal of Applied Physiology, Bethesda, v.85, n.4, p.1349-1356, 1998.
SODERLUND, K., HULTMAN, E. ATP and phosphocreatine changes in single human muscle fibers after intense electrical stimulation. American Journal of Physiology, Bethesda, v.261, n.6 (Part 1), p.E737-E741, 1991.
SODERLUND, K., GREENHAFF, P.L., HULTMAN, E. Energy metabolism in type I and II human muscle fibres during short term electrical stimulation at different frequencies. Acta Physiologica Scandinavica, Stockholm, v.144, n.1, p.15-22, 1992.
SODERLUND, K., BALSOM, P., EKBLOM, B. Creatine supplementation and high intensity exercise: influence on performance and muscle metabolism. Clinical Science, Colchester, v. 87 p.120-121, 1994. Supplement.
SPRIET, L. Anaerobic metabolism during high-intensity exercise. In: HARGREAVES, M. (Ed.). Exercise metabolism. Champaign : Human Kinetics, 1995. p.1-39.
TERRILLION, K.A., KOLKHORST, F.W., DOLGENER, F.A., JOSLYN, S.J. The effect of creatine supplementation on two 700-m maximal running bouts. International Journal of Sports Nutrition, Sttutgart, v.7, n.2, p.138-143, 1997.
THOMPSON, C.H., KEMP, G.J., SANDERSON, A.L., RADDA, G.K. Skeletal muscle mithocondrial function studied by kinetic analysis of postexercise creatine resynthesis. Journal of Applied Physiology, Bethesda, v.78, p.2131-2139, 1995.
VANDENBERGHE, K., GILLIS, N., Van HECKE, P., Van LEEMPUTTE, M., VANSTAPEL, F., HESPEL, P. Caffeine counteracts the ergogenic action of muscle creatine loading. Journal of Applied Physiology, Bethesda, v.80, n.2, p.452-457, 1996.
VANDENBERGHE, K., GILLIS, N., Van HECKE, P., Van LEEMPUTTE, M., VANGERVEN, L., HESPEL, P. Long term creatine intake is beneficial to muscle performance during resistance training. Journal of Applied Physiology, Bethesda, v.83, n.6, p.2055-2063, 1997.
VOLEK, J.S., KRAEMER, W.J., BUSH, J.A., BOETES, M., INCLEDON, T., CLARK, K.L., LYNCH, J.M. Creatine supplementation enhance muscular performance during high intensity resistance exercise. Journal of American Dietetic Association, Chicago, v.97, n.7, p.765-770, 1997.
WALKER, J. Creatine biosynthesis, regulation and function. Advances in Enzymology and Related Areas in Mollecular Biology, v.50, p.117-142, 1979.
WILLIAMS, M. Rating the sports ergogenics. The ergogenic edge. Champaing : Human Kinetics, 1998. p.178-182.
WILMORE, J., COSTILL, D. Basic energy systems. In: WILMORE, J., COSTILL, D. (Ed.). Physiology of sport and exercise. Champaign : Human Kinetics, 1994. p.92-121.
ZIEGENFUSS, T., LEMON, P., ROGERS, M., ROSS, R., YARASHESKI, K. Acute creatine ingestion: effects on muscle volume, anaerobic power, fluid volumes, and protein turnover. Medicine Science in Sports and Exercise, Madison, v.29 p.S127, 1997. (Abstract).
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