Hiperhomocisteinemia na insuficiência renal crônica

Autores

  • Fabiana Baggio NERBASS Universidade Federal de São Paulo
  • Sérgio Antonio DRAIBE Universidade Federal de São Paulo
  • Lilian CUPPARI Universidade Federal de São Paulo

Palavras-chave:

homocisteína, hiperhomocisteinemia, insuficiência renal crônica

Resumo

A homocisteína é um aminoácido sulfurado proveniente do metabolismo da metionina, cujo acúmulo anormal no plasma é um fator de risco para doenças vasculares, tanto na população em geral como nos pacientes com insuficiência renal crônica. Nestes, a prevalência de indivíduos com hiperhomocisteinemia é bastante elevada, mesmo na fase não dialítica da doença, em que a função renal está diminuída, mas ainda não é necessário tratamento dialítico. O principal fator que parece estar implicado na elevação dos níveis de homocisteína nestes pacientes com insuficiência renal crônica é a perda da massa renal, já que esta exerce uma importante função no metabolismo desse aminoácido. O tratamento da hiperhomocisteinemia na população em geral consiste na suplementação com as vitaminas envolvidas no seu metabolismo (folato, B6 e B12). Porém, em pacientes com insuficiência renal crônica, este tratamento não é completamente eficaz, pois apesar de promover a redução dos níveis de homocisteína, não alcança a normalização dos mesmos na maioria dos pacientes. Este estudo compreende uma revisão da etiologia da hiperhomocisteinemia na insuficiência renal crônica, sua relação com as doenças vasculares, seus principais determinantes e as formas de tratamento.

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Publicado

21-09-2023

Como Citar

Baggio NERBASS, F. ., DRAIBE, S. A. ., & CUPPARI, L. . (2023). Hiperhomocisteinemia na insuficiência renal crônica. Revista De Nutrição, 18(2). Recuperado de https://periodicos.puc-campinas.edu.br/nutricao/article/view/9825

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ARTIGOS DE REVISÃO