Suco de laranja reduz o colesterol em indivíduos normolipidêmicos

Autores/as

  • Thais Borges CÉSAR Universidade Estadual Paulista Júlio de Mesquita Filho
  • Layane Urzedo RODRIGUES Universidade Estadual Paulista Júlio de Mesquita Filho
  • Milena Salomão Peres de ARAÚJO Universidade Estadual Paulista Júlio de Mesquita Filho
  • Nancy Preising APTEKMANN Universidade Estadual Paulista Júlio de Mesquita Filho

Palabras clave:

Colesterol, Colesterol-LDL, Lipoproteínas, Suco

Resumen

Objetivos
Neste estudo foi investigado o efeito do consumo habitual de suco de laranja no perfil dos lípides e lipoproteínas em homens e mulheres normolipidêmicos.

Métodos
Todos os voluntários (n=29) consumiram 750mL/dia de suco de laranja durante 60 dias. Variáveis bioquímicas como perfil lipídico, apolipoproteínas, glicose, paraoxonase1 e o tamanho de HDL foram medidas antes e após o período de suplementação com suco de laranja. Também foram realizadas medidas antropométricas e inquéritos dietéticos.

Resultados
O consumo crônico de suco de laranja reduziu significativamente o colesterol total nos homens (11%, p<0,05) e nas mulheres (10%, p<0,05) e o LDL-C nos homens e mulheres (15%, p<0,05). O HDL-C e a apoA-I também diminuíram, refletindo a redução do colesterol total. Os triacilgliceróis, apo B, PON1, tamanho da HDL, IMC, gordura corporal e circunferência abdominal não foram modificados com o tratamento com suco de laranja.

Conclusão
Neste estudo, mostrou-se que o suco de laranja apresenta propriedade redutora sobre o colesterol, e foi sugerido que a associação dos flavonóides cítricos com a vitamina C previne o estresse oxidativo e o desenvolvimento da aterosclerose.

Citas

Terao J. Dietary flavonoids as antioxidants. Forum Nutr. 2009; 61:87-94.

Vinson JA, Liang X, Proch J, Hontz BA, Dancel J, Sandone N. Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease. Adv Exp Med Biol. 2002; 505:113-22.

Franke AA, Cooney RV, Henning SM, Custer LJ. Bioavailability and antioxidant effects of orange juice components in humans. J Agric Food Chem. 2005; 53(13):5170-78.

Rosa JM, Xian-Liu Z, Guthrie N. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Atern Ther. 2007; 13(6):44-8.

Silalahi J. Anticancer and health protective properties of citrus fruit components. Asia Pacific J Clin Nutr. 2002; 11(1):79-84.

Benavente-Garcia O, Castillo J, Alcaraz M, Vicente V, Del Rio JA, Ortuño A. Beneficial action of citrus flavonoids on multiple cancer-related biological pathways. Curr Cancer Drug Targets. 2007; 7(8): 795-809.

Whitman SC, Kurowska EM, Manthey JA, Daugherty A. Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Atherosclerosis. 2005; 178(1):25-32.

Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004; 52(10):2879-86.

Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia AL, Dandona P. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 2007; 30(6):1406-11.

Aptekmann NP, Cesar TB. Orange juice improved lipid profile and blood lactate of overweight middleaged women subjected to aerobic training. Maturitas. 2010 Aug 20. [Epub ahead of print]

Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piché LA, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr. 2000; 72(5): 1095-100.

Bok SH, Lee SH, Park YB, Bae KH, Son KH, Jeong TS, et al. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutarylCoA reductase and Acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr. 1999; 129(6):1182-5.

Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, et al. Flavonoid intake and risk of chronic diseases. Am Clin Nutr 2002; 76(3):560-8.

Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. J Am Med Assoc 1999; 81(15):1415-23.

Helmersson J, Arnlöv J, Larsson A, Basu S. Low dietary intake of beta-carotene, alpha-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort. Br J Nutr. 2009; 101(12):1775-82.

Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, et al. Antioxidants vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 2003; 108(9):1059-63.

Riso P, Visioli F, Gardana C, Grande S, Brusamolino A, Galvano F, et al. Effects of blood orange juice intake on antioxidant bioavailability on different markers related to oxidative stress. J Agric Food Chem. 2005; 53(4):941-7.

Sánchez-Moreno C, Cano MP, Ancos B, Plaza L, Olmedilla B, Granado F, et al. Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans. Am J Clin Nutr. 2003; 78(3):454-60.

Sánchez-Moreno C, Cano MP, Ancos B, Plaza L, Olmedilla B, Granado F, et al. High-pressurized orange juice consumption affects plasma vitamin C, antioxidative status and inflammatory markers in healthy humans. J Nutr. 2003; 133(7):2204-9.

Fuhrman B, Volkova N, Coleman R, Aviram M. Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J Nutri. 2005; 135(4):722-8.

Getz GS, Reardon CA. Paraoxonase, a cardioprotective enzyme: continuing issues. Curr Opin Lipidol. 2004; 5(3):261-7.

James RW, Deakin SP. The importance of high- -density lipoproteins for paraoxonase-1 secretion, stability, and activity. Free Rad Biol & Med. 2004; 37(12):1986-94.

Rozenberg O, Rosenblat M, Coleman R, Shih DM, Aviram M. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Rad Biol Med. 2003; 34(6):774-84.

Janssen I, Heymsfield SB, Allison DB, Kotler DP, Ross R. Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous and visceral fat. Am J Clin Nutr. 2002; 75(4):683-8.

Dâmaso AR. Métodos de avaliação da composição corporal. In: Nutrição e metabolismo na prevenção de doenças. Rio de Janeiro: Médica e Científica, 2001. p.125-52.

Institute of Medicine Food and Nutrition Board. Dietary reference intakes research synthesis. Workshop Summary. Washington: National Academy Press; 2006, p.310.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6): 499-502.

Lima ES, Maranhão RC. Rapid, simple laser-light- -scattering method for HDL particle sizing in whole plasma. Clin Chem. 2004; 50(6):1086-8.

Sociedade Brasileira de Cardiologia. IV Diretrizes Brasileiras sobre Dislipidemias e Prevenção da Aterosclerose do Departamento de Aterosclerose da Sociedade Brasileira de Cardiologia. Arq Bras Cardiol. 2007; 88(1):1-19.

Carr TP, Parks JS, Rudel LL. Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis. Arteriosc Thrombosis. 1992; 12(11):1274-83.

Garcia ACDB, Bonifácio NP, Vendramine RC, César TB. Influência do suco de laranja nos lípides sanguíneos e na composição corporal de homens normais e com dislipidemia. Nutrire. 2008; 33(2): 1-11.

Kurowska EM, Borradaile NM, Spence JD, Carroll KK. Hypocholesterolemic effects of dietary citrus juices in rabbits. Nutr Res. 2000; 20(1):121-9.

Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, Havel PJ. Twenty-four-hour endocrine and metabolic profiles following consumption of highfructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr. 2008; 87(5):1194-203.

Sprecher DL, Pearce GL. Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine. Metabolism. 2002; 51(9):1166-70.

Bonifácio NP, César TB. Influência da ingestão crônica do suco de laranja na pressão arterial e composição corporal. Rev Bras Hipert. 2009, 16(2): 76-81.

Libby P. Inflammation in atherosclerosis. Nature 2002; 420(6917):868-74.

Mooradian AD, Haas MJ, Wehmeier KR, Wong NC. Obesity-related changes in high-density lipoprotein metabolism. Obesity. 2008; 16(6):1152-60.

Cascieri MA. The potential for novel antiinflammatory therapies for coronary artery disease. Nature Reviews. Drug Discovery. 2002; 1(2):122-30.

Rosenblat M, Karry R, Aviram M. Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. Atherosclerosis. 2006; 187(1):74-81.

Publicado

2023-08-29

Cómo citar

Borges CÉSAR, T. ., Urzedo RODRIGUES, L. ., Peres de ARAÚJO, M. S. ., & Preising APTEKMANN, N. . (2023). Suco de laranja reduz o colesterol em indivíduos normolipidêmicos. Revista De Nutrição, 23(5). Recuperado a partir de https://periodicos.puc-campinas.edu.br/nutricao/article/view/9413

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Sección

ARTIGOS ORIGINAIS