Effects of soy protein containing isoflavones on women’s lipid profile: a meta-analysis
Palabras clave:
Cholesterol, Clinical trial, Women, Soy bean proteinResumen
Avaliar o efeito da proteína de soja isolada contendo isoflavonas sobre os níveis de lipídeos séricos em mulheres
adultas através de uma metanálise. Realizou-se uma busca sistemática de artigos nos bancos de dados Cochrane
Library, MedLine e Web of Science databases. Foram selecionados somente ensaios clínicos randomizados que
apresentavam os seguintes critérios: desenho do estudo paralelo ou crossover, publicados entre 1966 e 2005,
sujeitos do sexo feminino, especificação da quantidade administrada de proteína de soja isolada contendo
isoflavonas. Após criteriosa seleção e análise da qualidade dos estudos, conduziu-se uma metanálise incluindo
13 ensaios clínicos randomizados. O efeito do consumo de proteína de soja isolada sobre os níveis de lipídeos
séricos foi calculado utilizando-se os modelos de efeito fixo e efeitos aleatórios. Realizou-se análise em subgrupos
para avaliar a influência de covariáveis sobre alterações dos níveis de lipídeos sanguíneos. A metanálise mostrou
que o consumo de proteína de soja isolada está associado à diminuição do colesterol-total (-5,34mg/dL, ou
2.4%, p=0,03). Não se encontraram alterações significativas ao avaliar o lipoproteina de baixa densidade-
-colesterol, os triglicerídeos e o lipoproteina de alta densidade-colesterol. O consumo de proteína de soja
isolada, em quantidades maiores ou iguais a 40g/dia, reduziu os níveis de colesterol-total em 6,56mg/dl (95%
IC: -12,35 a 0,39, p=0,04). Os achados sugerem efeitos estatisticamente significativos de pequena magnitude
sobre os níveis de lipídeos séricos em mulheres, mas clinicamente insignificativos. Além disso, não foram
encontrados efeitos estatisticamente significativos sobre a concentração sérica de lipoproteina de baixa
densidade-colesterol, lipoproteina de alta densidade-colesterol ou triglicerídios.
Citas
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Derechos de autor 2023 Clarice Cardozo da Costa PREDIGER, Maria Teresa Anselmo OLINTO, Luís Carlos NÁCUL, Denize Rigetto ZIEGLER, Marcos Pascoal PATTUSSI
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
