Importância do zinco na nutrição humana
Palabras clave:
zinco, nutrição, morte celular, processos fisiológicos, saúdeResumen
Recentes pesquisas experimentais e clínicas têm reforçado a importância do zinco na saúde humana. O zinco possibilita várias funções bioquímicas, pois é componente de inúmeras enzimas, dentre estas, álcool desidrogenase, superóxido dismutase, anidrase carbônica, fosfatase alcalina e enzimas do sistema nervoso central. Participa na divisão celular, expressão genética, processos fisiológicos como crescimento e desenvolvimento, na transcrição genética, na morte celular, age como estabilizador de estruturas de membranas e componentes celulares, além de participar da função imune e desenvolvimento cognitivo. Sua deficiência pode causar alterações fisiológicas como, hipogonodismo, danos oxidativos, alterações do sistema imune, hipogeusia, danos neuropsicológicos e dermatites. Assim, devido a inúmeras pesquisas referentes a este mineral, este trabalho teve como objetivo mostrar os aspectos atuais sobre a essencialidade do zinco na nutrição humana.
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Szckurek EI, Bjornsson CS, Taylor CG. Dietary zinc deficiency and repletion modulate metallothionein immunolocalization and concentration in small intestine and liver of rats. J Nutr 2001; 131: 2132-8.
Sandstead HH. Understanding zinc: recent observations and interpretations. J Lab Clin Med 1994; 124(3):322-7.
McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr 2000; 130 Suppl:1437-46.
Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromiun, copper, iodine, iron, manganese, molybdnum, nickel, silicon, vanadium, and zinc. Washington: National Academy of Sciences; 2001.
Sandström B. Bioavailability of zinc. Eur J Clin Nutr 1997; 51(Suppl 1):S17-S9.
Zhou JR, Erdman JW. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995; 35(6): 495-508.
Organização Mundial de Saúde. Elementos traço na nutrição e saúde humana. São Paulo: Roca; 1998. p.63-91.
Lönnerdal B. Dietary factors influencing zinc absorption. J Nutr 2000; 130:1378-83.
Dyck KV, Tas S, Robberecht H, Deelstra H. The influence of different food components on the in vitro availability of iron, zinc and calcium from a composed meal. Int J Food Sci Nutr 1996; 47: 499-506.
Lee HH, Prasad AS, Brewer GJ, Owyang C. Zinc absorption in human small intestine. Am J Physiol 1989; 256:87-91.
Jackson MJ. Physiology of zinc: general aspects. In: Mills CF, editor. Zinc in human biology. London: Springer-Verlag; 1989. p.323-33.
Maret W. The function of zinc metallothionein: a link between cellular zinc and redox state. J Nutr 2000; 130 Suppl:1455-8.
Hempe JM, Cousins RJ. Cystein-rich intestinal protein and intestinal metallothionein: an inverse relationship as a conceptual model for zinc absorption in rats. J Nutr 1992; 122:89-95.
Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 1993; 73(1).
McMahon RJ, Cousins RJ. Mammalian zinc transporters. J Nutr 1998; 128:667-70.
Cousins RJ, McMahon RJ. Integrative aspects of zinc transporters. J Nutr 2000; 130 Suppl: 1384-7.
Liuzzi JP, Blanchard RK, Cousins RJ. Differenctial regulation of zinc transporter 1, 2 and 4 mRNA expression by dietary zinc in rats. J Nutr 2001; 131:46-52.
Michalczyk AA, Allen J, Blomeley RC, Ackland ML. Constitutive expression of hZnT4 zinc trasnporter in human breast epithelial cells. Biochem J 2002; 364:105-13.
Sekler I, Moran A, Hershfinkel M, Dori A, Margulis A, Birenzweig N, et al. Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain. J Comp Neurol 2002; 447(3):201-9.
Gibson RS. Principles of nutritional assessment. New York: Oxford University; 1990. p.543-53.
Fairweather-Tait SJ. Zinc in human nutrition. Nutr Res Rev 1988; 1:23-37.
Bray TM, Better WJ. The physiological role of zinc as an antioxidant. Free Radical Biol Med 1990; 8:281-91.
Hasanoglu E, Altan N, Sindel S, Ongun CO, Bali M, Altintas E. The relationship between erythrocyte superoxide dismutase activity and plasma levels of some trace elements (Al, Cu, Zn) of dialysis patients. Gen Pharmacol 1994; 25(1):107-10.
Powell SR. The antioxidant properties of zinc. J Nutr 2000; 130 Suppl:1447-54.
MacDonald RS. The role of zinc in growth and cell proliferation. J Nutr 2000; 130 Suppl:1500-8.
Ezaki O. Lib group metal ions (Zn2+, Cd2+, Hg2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes. J Biol Chem 1989; 264:16118-22.
Disilvestro RA. Zinc in relation to diabetes and oxidative disease. J Nutr 2000; 130 Suppl: 1509-11.
Mafra D, Cozzolino SMF. Avaliação do estado nutricional relativo ao zinco em pacientes com insuficiência renal crônica [dissertação]. São Paulo: Faculdade de Ciências Farmacêuticas; 1999.
Mafra D, Cozzolino SMF. Zinco protoprofirina como parâmetro de deficiência de ferro na insuficiência renal crônica. J Bras Nefrol 2000; 22:52-6.
Mafra D, Cuppari L, Cozzolino SMF. Iron and zinc status of patients with chronic renal failure who are not on dialysis. J Renal Nutr 2002; 12: 38-41.
Cunningham BC, Bass S, Fuh G, Wells JA. Zinc mediation of binding of human growth hormone to the human prolactin receptor. Science 1990; 250:1709-13.
Mocchegiani E, Muzzioli M. Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections. J Nutr 2000; 130 Suppl:1424-31.
Baum MK, Posner-Shor G, Campa A. Zinc status in human immunodeficiency virus infection. J Nutr 2000; 130 Suppl:1421-3.
Beck FWJ, Kaplan J, Fine N, Hadschu W, Prasad AS. Decreases expression of CD73 (ecto-5'-nucleotidase) in the CD8+ subset is associated with zinc deficiency in human patients. J Lab Clin Med 1997; 130:147-56.
Sandstead HH, Alcock NW. Zinc: an essential and unheralded nutrient. J Lab Clin Med 1997; 130:116-8.
Fraker PJ, King LE, Laakko T, Vollmer TL. The dynamic link between the integrity of the immune system and zinc status. J Nutr 2000; 130 Suppl: 1399-406.
Rink L, Kirchner H. Zinc-Altered immune function and cytokine production. J Nutr 2000; 130: 1407-11.
Frederickson CJ, Suh SW, Silva D, Frederickson CJ, Thompson RB. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 2000; 130 Suppl:1471-83.
Bhatnagar S, Taneja S. Zinc and cognitive development. Br J Nutr 2001; 85:139-45.
Christian P, West KP. Interactions between zinc and vitamin A: an update. Am J Clin Nutr 1998; 68 Suppl:235-41.
Peczkowska M, Kabat M, Janaszek-Sitkowska H, Pulawska M. Evaluation of selected parameters of zinc metabolism in patients with primary hypertension. Pol Arch Med Wewn 1996; 95(3):198-204.
Stallard L, Reeves PG. Zinc deficiency in adults rats reduces the relative abundance of testis-specific angiotensin-converting enzyme mRNA. J Nutr 1997; 127:25-9.
Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr 1996; 15(2):113-20.
Hambidge M. Human zinc deficiency. J Nutr 2000; 130 Suppl:1344-9.
Blanchard RK, Cousins RJ. Regulation of intestinal gene expression by dietary zinc: induction of uroguanylin mRNA by zinc deficiency. J Nutr 2000; 130:1393-8.
Black RE, Sazawal S. Zinc and childhood infectious disease morbidity and mortality. Br J Nutr 2001; 85:125-9.
Strand TA, Chandryo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics 2002; 109(5): 898-903.
Goto T, Komai M, Suzuki H, Furukawa Y. Long- -term zinc deficiency decreases taste sensitivity in rats. J Nutr 2001; 130 Suppl:305-10.
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Derechos de autor 2023 Denise MAFRA, Sílvia Maria Franciscato COZZOLINO
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
