Association of hematology profile with serum 25-hydroxy vitamin D and Bsml polimorphism in community-dwelling older adults
Palabras clave:
Anemia, Aged, Hemoglobins, Polymorphism, Vitamin DResumen
Objective
To investigate the association between serum level of 25-hydroxy vitamin D and the Vitamin D Receptos gene BsmI polymorphism in the blood profile of community-dwelling older adults.
Methods
This cross-sectional study included 142 older males and females. A questionnaire collected socio demographic information, medical history, and factors associated with sun exposure. Weight, height, and waist circumference were measured. Biological material was collected to analyze biochemical parameters 25-hydroxy vitamin D, parathormone, serum calcium, urea, creatinine, liver enzymes, and blood profile) and to verify the presence of the vitamin D receptos gene BsmI polymorphism.
Results
Most participants were female (80.3%). The mean levels of 25-hydroxy vitamin D, hemoglobin, and hematocrit were 32.1±7.3 ng/dL, 13.5±1.5 d/dL, and 40.0±4.4%, respectively. Fifty-eight (40.8%) participants had vitaminD insufficiency/deficiency (25.7±3.3 ng/mL), and 18 (12.6%) had anemia. Serum vitamin D was associated with hemoglobin (p=0.030) and hematocrit (p=0.032). However, when subjects were categorized as anemic or not anemic, said association was not maintained (p=0.270). Moreover, the BsmI polymorphism was not associated with hemoglobin and hematocrit levels, regardless of vitamin D status.
Conclusion
The serum level of vitamin D is associated with hematocrit and hemoglobin levels in older adults. However, these blood parameters were not associated with the vitamin D receptor gene BsmI polymorphism.
Citas
Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves PH, Newman AB, et al. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: The cardiovascular health study. Arch Intern Med. 2005; 165:2214-20.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. http:// dx.doi.org/10.1210/jc.2011-0385
Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood. 2004; 104(8):2263-8. http://dx.doi.org/10.1182/blood 2004-05-1812
Neves JP, Silva AS, Morais LC, Diniz Ada S, Costa MJ, Asciutti LS, et al. 25-hydroxyvitamin D concentrations and blood pressure levels in hypertensive elderly patients. Arq Bras Endocrinol Metabol. 2012; 56(7):415-22. http://dx.doi.org/10. 1590/S0004-27302012000700002
Arantes HP, Kulak CA, Fernandes CE, Zerbini C, Bandeira F, Barbosa IC, et al. Correlation between 25-hydroxyvitamin D levels and latitude in Brazilian postmenopausal women: From the arzoxifene generations trial. Osteoporos Int. 2013; 24(10):2707- 12. http://dx.doi.org/10.1007/s00198-013-2407-5
Lichtenstein A, Ferreira-Júnior M, Sales MM, Aguiar FB, Fonseca LAM, Sumita NM, et al. Vitamina D: ações extraósseas e uso racional. Rev Assoc Med Bras. 2013; 59(5):495-506. http://dx.doi.org/10. 1016/j.ramb.2013.05.002
Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: Association with anemia of inflammation. Blood. 2011; 117(10):2800-6. http://dx.doi.org/10.1182/ blood-2010-09-309708
Patel NM, Gutiérrez OM, Andress DL, Coyne DW, Levin A, Wolf M. Vitamin D deficiency and anemia in early chronic Kidney disease. Rev Kidney Int. 2010; 77(8):715-20. http://dx.doi.org/10.1038/ki. 2009.551
Han SS, Kim M, Kim H, Lee SM, Oh YJ, Lee JP, et al. Non-Linear relationship between Serum 25- -hydroxyvitamin D and hemoglobin in Korean females: The Korean national health and nutrition examination survey 2010-2011. Plos One. 2013; 8(8):1-7. http://dx.doi.org/10.1371/journal.pone. 0072605
Yoo EH, Cho HJ. Prevalence of 25-Hydroxyvitamin D Deficiency in Korean patients with anemia. J Clin Lab Anal. 2014; 29(2):129-34. http://dx.doi.org/ 10.1002/jcla.21740
Alon DB, Chaimovitz C, Dvilansky A, Lugassy G, Douvdevani A, Shany S, et al. Novel role of 1, 25(OH)(2)D(3) in induction of erythroid progenitor cell proliferation. Exp Hematol. 2002; 30(5):403-9. http://dx.doi.org/10.1016/S0301-472X(02)00789- 0
Santoro D, Caccamo D, Lucisano D, Buemi M, Sebekova K, Teta D, et al. Interplay of vitamin D, erythropoiesis, and the renin-angiotensin system. Bio Med Res Int. 2015; 1(1):1-11. http://dx.doi.org/ 10.1155/2015/145828
Norman AW. Minireview: Vitamin D receptor: New assignments for an already busy receptor. Endocrinology. 2006; 147(12):5542-8. http://dx. doi.org/10.1210/en.2006-0946
Reichel H, Koeffler HP, Norman AW. The role of the vitamin D endocrine system in health and disease. N Engl J Med. 1989; 320(15):980-91. http:// dx.doi.org/10.1056/NEJM198904133201506
Meguro S, Tomita M, Katsuki T, Kato K, Oh H, Ainai A, et al. Plasma 25-Hydroxyvitamin D is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. Int J Endocrinol. 2011; 1(1):1-5. http:// dx.doi.org/10.1155/2011/362981
Hirani V, Cumming RG, Blyth F, Naganathan V, Couteur DGL, Waite LM, et al. Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: The concord health and ageing in men Project. Age. 2015; 37(8):1-13. http://dx.doi.org/10.1007/s11 357-015-9749-1
Schuch NJ, Garcia VC, Vívolo SR, Martini LA. Relationship between vitamin D receptor gene polymorphisms and the components of metabolic syndrome. Nutr J. 2013; 12(96):1-7. http://dx.doi. org/10.1186/1475-2891-12-96
Sezer S, Tutal E, Bilgic A, Ozdemir FN, Haberal M. Possible influence of vitamin D receptor gene polymorphisms on recombinant human erythropoietin requirements in dialysis patients. Transplant Proc. 2007; 39(1):40-4. http://dx.doi.org/10.1016/j. transproceed.2006.10.214
Amato M, Pacini S, Aterini S, Punzi T, Gulisano M, Ruggiero M. Iron Indices and vitamin D receptor plymorphisms in hemodialysis patients. Adv Chronic Kidney Dis. 2008; 15(2):186-90. http://dx.doi.org/ 10.1053/j.ackd.2008.01.013
Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006; 371(1-2):1-12. http://dx.doi.org/10.1016/j.cca. 2006.02.016
World Health Organization. Physical status: The use and interpretation of anthropometry. Geneva: WHO; 1995.
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16(1):31-41.
Aidar M, Line SR. A Simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J. 2007; 18(2):148-52. http://dx.doi. org/10.1590/S0103-64402007000200012
Coutard A, Garlantézec R, Estivin S, Andro M, Gentric A. Association of vitamin D deficiency and anemia in a hospitalized geriatric population: Denutrition as a confounding factor. Ann Hematol. 2013; 92(5):615-9. http://dx.doi.org/10.1007/ s00277-012-1633-9
Sim JJ, Lac PT, Liu IL, Mequerditchian SO, Kumar VA, Kujubu DA, et al. Vitamin D deficiency and anemia: A cross-sectional study. Ann Hematol. 2010; 89(5):447-52. http://dx.doi.org/10.1007/ s00277-009-0850-3
Kiss Z, Ambrus C, Almasi C, Berta K, Deak G, Horonyi P, et al. Serum 25(OH)-cholecalciferol concentration is associated with hemoglobin level and erythropoietin resistance in patients on maintenance hemodialysis. Nephron Clin Pract. 2011; 117(4):373-8. http://dx.doi.org/10.1159/000 321521
Ertürk S, Kutlay S, Karabulut HG, Keven K, Nergizoglu G, Ates K, et al. The impact of vitamin D receptor genotype on the management of anemia in hemodialysis patients. Am J Kidney Dis. 2002; 40(4):816-23. http://dx.doi.org/10.1053/ajkd. 2002.35694
Finkelstein JL, Mehta S, Duggan C, Spiegelman D, Aboud S, Kupka R, et al. Predictors of anaemia and iron deficiency in HIV-infectedpregnant women in Tanzania: A potential role for vitamin D and parasitic infections. Public Health Nutr. 2012; 15(5):928-937. http://dx.doi.org/10.1017/S1368980011002369
Zittermann A, Kuhn J, Dreier J, Knabbe C, Prokop S, Gummert JF, et al. Association of 25- -hydroxyvitamin D with anemia risk in patients scheduled for cardiac surgery. Int J Lab Hematol. 2014; 36(1):29-36. http://dx.doi.org/10.1111/ijlh. 12112
Meguro S, Tomita M, Katsuki T, Kato K, Oh H, Ainai A, et al. Plasma 25-Hydroxyvitamin D is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. Int J Endocrinol. 2011; 1(1):1-5. http://dx. doi.org/10.1155/2011/362981
Liu T, Zhong S, Liu L, Liu S, Li X, Zhou T, et al. Vitamin D deficiency and the risk of anemia: A metaanalysis of observational studies. Ren Failure. 2015; 17(6):929-34. http://dx.doi.org/10.3109/08860 22X.2015.1052979
Smith EM, Tangpricha V. Vitamin D and anemia: Insights into an emerging association. Curr Opin Endocrinol Diabetes Obes. 2015; 22(6):432-8. http://dx.doi.org/10.1097/MED.0000000000 000199
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Derechos de autor 2023 Alexandre Sérgio SILVA, Chahira Taha Mahd Ibrahim ISSA, Dayanna Joyce Marques QUEIROZ, Darlene Carmati PERSUHN, Eduarda Pontes dos Santos ARAÚJO, Maria da Conceição Rodrigues GONÇALVES
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