The effect of kefir consumption on the lipid profile for individuals with normal and dyslipidemic properties: a randomized controlled trial
Palabras clave:
Cholesterol, Dyslipidemia, Kefir, Probiotics, TriglyceridesResumen
Objective
This research was conducted as a prospective, self-controlled, eight-week clinical trial to investigate the effect of kefir consumption on the lipid profile of individuals with normal and dyslipidemic properties.
Methods
Kefir microorganisms given to volunteer subjects were determined using classical microbial count methods and qReal-Time Polymerase Chain Reaction. The study was carried out with 23 volunteer hospital health personnel between the ages of 20 and 55 who met the research criteria and did not have any health problems. The volunteers regularly consumed kefir on an empty stomach for four weeks. In the last stage, the eight-week study was completed by making blood and anthropometric measurements of the subjects, who continued to be studied without kefir consumption for four more weeks.
Results
Considering the changes in the serum lipid profiles of 13 individuals with dyslipidemic symptoms during the 4-week period they consumed kefir, Total Cholesterol values decreased by 9.15% compared to initial values, LDL-Cholesterol values decreased by 10.64%, HDL-Cholesterol values decreased by 6.9%, and triglyceride values decreased by 2.46%. The changes in the serum lipid profiles of 13 individuals with dyslipidemic findings at the end of an eight-week study were a 5.71% decrease in total cholesterol values (p<0.018) considered statistically significant, as well as a 5.31% decrease in LDL-Cholesterol values (p<0.021); the HDL-Cholesterol results were found to be significant with an 8.58% decrease in the values (p<0.035) and insignificant with a 17.21% increase in the triglyceride values (p<0.926). We concluded that regular kefir consumption was effective in both women and men in lowering total cholesterol and LDL-Cholesterol from blood lipid profiles, especially in individuals with dyslipidemic symptoms, while this effect was not observed in normal individuals.
Conclusion
Kefir can positively affect the total cholesterol and LDL-Cholesterol blood parameters of dyslipidemic individuals with high serum lipid values.
Citas
Kılıçarslan MG, Şahin EM. The first step in dyslipidemia management in the light of current guidelines: Lifestyle changes. Turk Aile Hek Derg. 2019;23(1):3140. https://doi.org 10.15511/tahd.19.00131
Vasquez AT, Pereira TMC, Peotta VA. Probiotics as beneficial dietary supplements to prevent and treat cardiovascular diseases: uncovering their impact on oxidative stress. Oxid Med Cell Longev. 2019;3086270. https://doi.org/10.1155/2019/3086270
Pimenta FS, Luaces-Regueira M, Ton AMM, Campagnaro BP, Campos-Toimil M, Pereira TMC, Vasquez EC. Mechanisms of action of kefir in chronic cardiovascular and metabolic diseases. Cell Physiol Biochem. 2018;48(5):1901-14. https://doi.org/10.1159/000492511
Sun J, Buys N. Effect of probiotics consumption lowering lipid sand VCD risk factors: a systematic review and meta – analysis of randomized controlled trials. Ann Med. 2015;47(6):430-40. https://doi.org/10.3109/07853890.2015.1071872
Jones ML, Martoni CJ, Parent M, Prakash S. Cholesterol lowering efficacy of a micro encapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. Br J Nutr. 2012;107:1505-13.
Zoral S. Determination of probiotic properties of strains [tesis]. Kırşehir: Ahi Evran University; 2013.
Jacobson TA, Ito MK, Maki KC, Orringer CE, Bays HE, Jones, PH, et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1. J Clin Lipidol. 2015;9:1-122.
Jovanović, JN, Nikolić, B, Šeatović, S, Zavišić G, Mitić-Ćulafić D, Vuković-Gačić B, et al. Characterization of some potentially probiotic Lactobacillus strains of human origin. Food Sci Biotechnol. 2015;24:1781-88. https://doi.org/10.1007/s10068-015-0232-7
Lovita A, Andiany A, Latipudin D, Tubagus B, Cahyani C. Effect of fermented cow and soybean milk with probiotic in improving blood cholesterol and triglyceride levels on broilers. Int J Poult Sci. 2018;17:600-4.
Park S, Bae JH. Probiotics for weight loss: a systematic review and meta-analysis, Nutr Res. 2015;35(7):566-75.
Shimizu M, Hashiguchi M, Shiga T, Tamura H-O, Mochizuki M. Meta-analysis: effects of probiotic supplementation on lipid profiles in normal to mildy hypercholesterolemic individuals. Plos One. 2015;16(10):e0139795.
Sharma S, Kurpad AV, Puri S. Potential of probiotics in hypercholesterolemia: a meta-analysis. Indian J Public Health. 2016;60:280-6.
Wu Y, Zhang Q, Ren Y, Ruan Z. Effect of probiotic Lactobacillus on lipidprofile: a systematic review and meta-analysis of randomized, controlled trials. Plos One. 2017;12(6):e0178868.
Bellikci-Koyu E, Sarer-Yureklı BP, Akyon Y, Aydın-Kose F, Karagozlu C, Ozgen AG, et al. Effects of regular kefir consumption on gut microbiota in patients with metabolic syndrome: a parallel-group, randomized, controlled study. Nutrients. 2019;11:2089. https://doi.org/10.3390/nu11092089
Fuentes MC, Lajo T, Carrion JM, Cune J. Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in ypercholesterolaemic adults. Br J Nutr. 2013;109(10):1866-72.
Jascolka TL, Aguilar EC, Teixeira LG, Lages PC, Raimundo IC. Kefir supplementation improves lipid profile and oxidative stress but does not reduce atherosclerotic lesion in apoe deficient mice. J Food Nutr Disor. 2013;2:3. https://doi.org/10.4172/2324-9323.1000113
Tok E, Aslım B. The roles of some lactic acid bacteria used as probiotics in cholesterol assimilation and bile salt deconjugation. Turk Microbil Soc Journal. 2007;37(1):62-8.
Thakkar P, Modi H, Dabhi B, Prajapati J. Bile tolerance, bile deconjugation and cholesterol reducing properties of Lactobacillus strains isolated from traditional fermented foods. Int J Fermented Foods, 2014;3(2):157-65. https://doi.org/10.5958/2321-712X.2014.01316.7
Tofighiyan T, Kooshki A, Hoseini BL, Mohammadi M. The effects of probiotic on serum lipid profiles in patients with type 2 diabetes mellitus: a randomized clinical trial. J Food Sci Nutr Res. 2016;4(12):795-98. https://doi.org/10.12691/jfnr-4-12-5
Catapano AL, Graham I, Backer G, Wiklund O, Chapman MJ, Drexel H, et al. 2016 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37:2999-3058.
Ahn HY, Kim M, Ahn YT, Sim JH, Choi ID, Lee SH, et al. The triglyceride lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY032: reduction of fasting plasmaly so phosphatidyl cholines in non-diabetic and hypertriglyceridemic subjects. Nutr Metab Cardiovasc Dis. 2015;25(8):724-33.
Ivey KL, Hodgson JM, Kerr DA, Thompson PL, Stojceski B, Prince RL. The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomized controlled trial. Nutr Metab Cardiovasc Dis. 2015;25(1):46-51.
Soleimani A, Zarrati Mojarrad M, Bahmani F, Taghizadeh M, Ramezani M, Tajabadi-Ebrahimi M, et al. Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. Kidney Int. 2017;91(2):435-42.
Cox AJ, West NP, Horn PL, Lehtinen MJ, Koerbin G, Pyne DB, et al. Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults. Eur J Clin Nutr. 2014;68(11):1255-7.
Rocha-Gomes A, Escobar A, Soares JS, Silva AA, Dessimoni-Pinto NAV, Riul TR. Chemical composition and hypocholesterolemic effect of milk kefir and water kefir in Wistar rats. Rev Nutr. 2018;31(2):137-45. http://dx.doi.org/10.1590/1678-98652018000200001
Hernández-Gómez JG, López-Bonilla A, Trejo-Tapia G, Ávila-Reyes SV, Jiménez-Aparicio AR, Hernández-Sánchez H. In vitro Bile Salt Hydrolase (BSH) activity screening of different probiotic microorganisms. Foods. 2021;10(3):674. https://doi.org/10.3390/foods10030674
Pereira MCA, Barcelos MFP, Sousa MSB, Pereira JAR. Effects of the kefir and banana pulp and skin flours on hypercholesterolemic rats. Acta Cir. Bras. 2013;28(7):481-86.
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Derechos de autor 2023 Ilkay YILMAZ, Bahattin ARSLAN
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
