Appetite-related hormone levels in obese women with and without binge eating behavior

Authors

  • Paula Paraguassú BRANDÃO Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Departamento de Ciências Fisiológicas, Laboratório de Fisiologia da Nutrição e do Desenvolvimento
  • Érica Patrícia GARCIA-SOUZA Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Departamento de Ciências Fisiológicas, Laboratório de Fisiologia da Nutrição e do Desenvolvimento
  • Fabiana Alves NEVES Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Departamento de Ciências Fisiológicas, Laboratório de Fisiologia da Nutrição e do Desenvolvimento
  • Mário José dos Santos PEREIRA Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Departamento de Ciências Fisiológicas, Laboratório de Fisiologia da Nutrição e do Desenvolvimento
  • Rosely SICHIER Universidade do Estado do Rio de Janeiro, Instituto de Medicina Social, Departamento de Epidemiologia
  • Aníbal Sanchez MOURA Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Departamento de Ciências Fisiológicas, Laboratório de Fisiologia da Nutrição e do Desenvolvimento

Keywords:

Ghrelin, Insulin, Obesity, PYY 3-36, Binge-eating disorder

Abstract

Objective
The aim of this study was to evaluate serum levels of appetite-related hormones (peptide YY3-36, total ghrelin, leptin and insulin) before and after consumption of a meal in obese women with and without binge eating episodes and normal weight women.
Methods
Twenty-five women aged 32-50 years were invited to participate in this study, including 9 normal weight women without binge eating episodes (20-25kg/m2, group 1), 9 obese women with binge eating episodes (u30kg/m2, group 2), and 7 obese women without binge eating episodes (group 3). Four blood samples were collected from each participant, one being 60 minutes before and three being 15, 45 and 90 minutes after a meal. The composition of the meal was 55% carbohydrates, 15% protein and 30% lipids.
Results
Group 3 presented increased HOMA-IR (M=2.5, SD=1.04) when compared with group 1 (M=1.5, SD=0.53) and group 2 (M=1.8, SD=0.58), p=0.04. Body mass index (p<0.0001), leptin (p<0.0001) and insulin (p=0.01) were higher in group 3 than in the other groups before and after the meal. Additionally, total ghrelin (p=0.003) and PYY3-36 (p=0.02) levels were lower in group 2 than in the other groups before and after the meal. After adjustment for body mass index, only the lower PYY3-36 level of group 2 remained statistically different from the other groups (p=0.01).
Conclusion
Our study suggests that lower levels of PYY 3-36 are associated with binge eating in obese women.

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Published

2011-10-30

How to Cite

BRANDÃO, P. P. ., GARCIA-SOUZA, Érica P., NEVES, F. A. ., PEREIRA, M. J. dos S. ., SICHIER, R. ., & MOURA, A. S. (2011). Appetite-related hormone levels in obese women with and without binge eating behavior. Brazilian Journal of Nutrition, 24(5). Retrieved from https://periodicos.puc-campinas.edu.br/nutricao/article/view/9843

Issue

Vol. 24 No. 5 (2011): Revista de Nutrição

Section

ORIGINAL ARTICLE

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Copyright (c) 2023 Paula Paraguassú BRANDÃO, Érica Patrícia GARCIA-SOUZA, Fabiana Alves NEVES, Mário José dos Santos PEREIRA, Rosely SICHIER, Aníbal Sanchez MOURA

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