Relationship between vitamin A and biochemical markers of iron status in children and adolescents
Keywords:
Adolescent, Child, Iron deficiency, Vitamin A deficiencyAbstract
Objective
The objective of this study was to verify the relationship between vitamin A and the biochemical markers of iron status.
Methods
A total of 178 individuals aging from 7 to 17 years participated in this study, all living in Jequié, BA. The individuals were submitted to blood tests to dose retinol and biochemical iron markers. Furthermore, anthropometric measurements and stool analyses were done and dietary information regarding iron intake, socio-environmental and home conditions of the family were collected. Multiple linear regression analysis was done to assess the association of interest.
Results
A positive and statistically significant association was found between the levels of serum retinol and hemoglobin (p=0.007), serum iron (p=0.010) and iron-saturated tranferrin (p=0.027). These findings remained unchanged after adjusting the models for demographic variables, parasitic infections (Schistosoma mansoni, Trichiura trichuris, Ascaris lumbricoides and ancylostomiasis), consumption of bioavailable dietary iron and environmental and home conditions.
Conclusion
Vitamin A seems to contribute to the increase of organic iron of the population, especially in areas were deficiency of vitamin A and iron-deficiency anemia coexist.
References
Poveda E, Cuartas A, Guarin S, Forero Y, Villarreal E. Iron and vitamin A micronutrient status, risk factors for their deficiencies and anthropometric assessment in preschool child from Funza municipality, Colombia. Biomedica (Bogotá). 2007; 27(1):76-93.
Mejia LA, Hodges RE, Rucker RB. Role of vitamin A in the absorption, retention and distribution of iron in the rat. J Nutr. 1979; 109(1):129-37.
Hodges RE, Rucker RB, Gardner RH. Vitamin A deficiency and abnormal metabolism of iron. Ann N Y Acad Sci. 1980; 355:58-61.
Mejia LA, Arroyave G. Biological interrelation between vitamin A and iron. Arch Latinoam Nutr. 1982; 32(1):32-7.
Ameny MA, Raila J, Walzel E, Schweigert FJ. Effect of iron and/or vitamin A re-supplementation on vitamin A and iron status of rats after a dietary deficiency of both components. J Trace Elem Med Biol. 2002; 16(3):175-8.
Panth M, Shatrugna V, Yasodhara P, Sivakumar B. Effect of vitamin A supplementation on haemoglobin and vitamin A levels during pregnancy. Br J Nutr. 1990; 64(2):351-8.
Suharno D, West CE, Muhilal, Logman MH, Waart FG, Karyadi D, et al. Cross-sectional study on the iron and vitamin A status of pregnant women in West Java, Indonesia. Am J Clin Nutr. 1992; 56(6):988-93.
Mejia LA, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Am J Clin Nutr. 1988; 48(3):595-600.
Bloem MW, Wedel M, Egger RJ, Speek AJ, Schrijver J, Saowakontha S, et al. Iron metabolism and vitamin A deficiency in children in northeast Thailand. Am J Clin Nutr. 1989; 50(2):332-8.
Bloem MW, Wedel M, van Agtmaal EJ, Speek AJ, Saowakontha S, Schreurs WH. Vitamin A intervention: short-term effects of a single, oral, massive dose on iron metabolism. Am J Clin Nutr. 1990; 51(1):76-9.
Ahmed F, Barua S, Mohiduzzaman M, Shaheen N, Bhuyan MA, Margetts BM, et al. Interactions between growth and nutrient status in schoolage children of urban Bangladesh. Am J Clin Nutr. 1993; 58(3):334-8.
Brito LL, Barreto ML, Silva RC, Assis AM, Reis MG, Parraga I, et al. Risk factors for iron-deficiency anemia in children and adolescents with intestinal helminthic infections. Rev Panam Salud Publica. 2003;14(6):422-31.
United Nations Children’s Fund. Preventing iron deficiency in women and children: background and consensus on key technical issues and resources for advocacy, planning and implementing national programmes. New York: UNICEF; 1998.
Bieri JG, Tolliver TJ, Catignani GL. Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr. 1979; 32(10): 2143-9.
von Schenck H, Falkensson M, Lundberg B. Evaluation of “HemoCue,” a new device for determining hemoglobin. Clin Chem. 1986; 32(3):526-9.
Pereira Jr DB. Utilization of the Kato-Katz-method (thick-smear technique) the diagnosis of Isospora (author’s transl). Rev Bras Pesq Med Biol. 1979; 12(4-5):351-2.
Philippi ST, Szarfarc SC, Laterza CR. Virtual Nutri. Sistema de análise nutricional. Versão 1.0 for Windows. São Paulo: Universidade de São Paulo; 1996.
Monsen ER, Balintfy JL. Calculating dietary iron bioavailability: refinement and computerization. J Am Diet Assoc. 1982; 80(4):307-11.
Majia LA, Hodges RE, Arroyave G, Viteri F, Torun B. Vitamin A deficiency and anemia in Central American children. Am J Clin Nutr. 1977; 30(7): 1175-84.
Mohanram M, Kulkarni KA, Reddy V. Hematological studies in vitamin A deficient children. Int J Vitam Nutr Res. 1977; 47(4):389-93.
Li JH, Piao JH, Guo N, Yang LC. Study on the correlation of vitamin A and iron status in children. Wei Sheng Yan Jiu. 2006; 35(2):182-3.
Zimmermann MB, Biebinger R, Rohner F, Dib A, Zeder C, Hurrell RF, et al. Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr. 2006; 84(3): 580-6.
Mwanri L, Worsley A, Ryan P, Masika J. Supplemental vitamin A improves anemia and growth in anemic school children in Tanzania. J Nutr. 2000; 130(11):2691-6.
Mejia LA, Arroyave G. The effect of vitamin A fortification of sugar on iron metabolism in preschool children in Guatemala. Am J Clin Nutr. 1982; 36(1):87-93.
Staab DB, Hodges RE, Metcalf WK, Smith JL. Relationship between vitamin A and iron in the liver. J Nutr. 1984; 114(5):840-4.
Duarte EC, Schneider MC, Sousa R, Ramalho WM, Sardinha LM. Epidemiologia das desigualdades em saúde no Brasil: um estudo exploratório. Brasília: OPS; 2002.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Rita de Cássia Ribeiro SILVA, Ana Marlúcia Oliveira ASSIS, Mônica Leila Portela de SANTANA, Maurício Lima BARRETO, Luciara Leite BRITO, Mitermayer Galvão REIS, Isabel Martin PARRAGA, Ronald Edward BLANTON
This work is licensed under a Creative Commons Attribution 4.0 International License.
