Changes in the anthropometric parameters of patients with the Human Immunodeficiency virus or Acquired Immunodeficiency Syndrome: a prospective study

Authors

  • Maíra Ladeia Rodrigues CURTI Universidade de São Paulo
  • Luara Bellinghausen ALMEIDA Universidade de São Paulo
  • Patrícia Constante JAIME Universidade de São Paulo

Keywords:

Anthropometry, Body fat, Acquired Immunodeficiency Syndrome, Nutritional status, Lipodystrophy

Abstract

Objective
The objective of this study was to assess the nutritional status and changes in the anthropometric indicators of patients with the human Immunodeficiency virus or acquired immunodeficiency syndrome using the highly active antiretroviral therapy.

Methods
This is a 12-month prospective cohort study of adult males and females who recently started antiretroviral therapy. The anthropometric indicators studied were body mass index, waist circumference and subscapular, biceps and triceps skinfold thicknesses, taken 4 times during the year in 3-month intervals. The variables were described according to medians and 25 and 75 percentiles and analyzed by ANOVA for repeated measurements.

Results
The studied population consisted of 53 patients, mostly males (81%) aged 30 to 39 years. Only subscapular skinfold thickness changed significantly over time (T1=13.70 vs T4=16.00, p<0.001), indicating cervical lipohypertrophy (buffalo hump).

Conclusion
The findings of this study, although limited, show the need to monitor anthropometric parameters associated with morphological changes, especially those used in the diagnosis of abdominal and dorsocervical fat accumulation.

References

Joint United Nations Programme on HIV/AIDS (UNAIDS). 2006 Report on the global AIDS epidemic: a UNAIDS 10th anniversary special edition. Geneva: Unaids; 2006.

Brasil. Ministério da Saúde. Programa Nacional de DST e AIDS. 26ª semanas epidemiológicas 2006. Bol Epidemiol AIDS/DST. 2006; 3(1):1-50.

Dourado I, Veras MASM, Barreira D, Brito AM. AIDS epidemic trends after the introduction of antiretroviral therapy in Brazil. Rev Saúde Pública. 2006; 40 (Supl):9-17. doi: 10.1590/s0034-89102006000800003.

Valente MM, Reis AF, Machado DM, Succi RCM, Chacra AR. Alterações metabólicas da síndrome lipodistrófica do HIV. Arq Bras Endocrinol Metabol. 2006; 49(6):871-81.

Li HY, Silva ACCMS, Santos SS. Síndrome lipodistrófica e HIV/Aids. J Bras Aids. 2002; 3(2):23-35.

Lumpkin M. FDA Public health advisory: reports of diabetes and hyperglycemia in patients receiving protease inhibitor for the treatment of human immunodeficiency virus (HIV). Washington (DC): US Government Printing Office; 1997.

Basílio de Oliveira CA, Valle HA, Serra M, Skowronski CSP. Lipodistrofia na AIDS. In: ATLAIDS Atlas de patologia da SIDA. São Paulo: Atheneu; 2005.

Santosa CP, Felipe YX, Bragab PE, Ramosa D, Lima RO, Segurado AC. Self-perception of body changes in persons living with HIV/AIDS: prevalence and associated factors. AIDS 2005; 19(Supl 4): S14-S21. doi: 10.1590/s0034-891022200600050012.

Jaime PC, Florindo AA, Latorre MRDO, Segurado AAC. Central obesity and dietary intake in HIV/AIDS patients. Rev Saúde Pública. 2006; 40(4): 634-40.

Power R, Tate HL, McGill SM, Taylor C. A qualitative study of the psychosocial implications of lipodystrophy syndrome on HIV positive individuals. Sex Transm Infect 2003; 79(2):137-41. doi: 10:1136/sti.79(2)137-41.

Burgoyne R, Collins E, Wagner C, Abbey S, Halman M, Nur M, et al. The relationship between lipodystrophy-associated body changes and measures of quality of life and mental health for HIV-positive adults. Qual Life Res. 2005; 14(4): 981-90. doi: 10.1007/s11136-004-2580-2.

World Health Organization. Diet, nutrition and the prevention of chronic diseases. Report of a joint WHO/FAO expert consultation. Geneva; 2003. WHO Technical Report Series, 916.

Gelato MC. Insulin and carbohydrate dysregulation. Clin Inf Dis. 2003; 36 (Suppl.2): 91-5. doi: 1058.4838/2003/3607s2-0007.

Health KV, Hogg RS, Chan KJ, Harris M, Montessori V, Oshaughnessy MV, et al. Lipodystrophyassociated morphological, cholesterol and triglyceride abnormalities in population-based HIV/AIDS treatment database. AIDS 2001; 15(3):231-9.

Almeida LB, Jaime PC. Aspectos atuais sobre nutrição e AIDS na era da terapia antiretroviral de alta atividade. J Bras AIDS. 2006; 7(1):1-48.

Knox TA, Zafonte-Sanders M, Fields-Gardner C, Moen K, Johansen D, Paton N. Assessment of nutritional status, body composition, and human immunodeficiency virus-associated morphologic changes. Clin Infetc Dis. 2003 (Suppl 2):63-8. doi: 1058.4838/2003/3607s2-0003.

World Heath Organization. Physical status: the use and interpretation of anthropometry. Geneva: WHO; 1995 Technical Report Series, 854.

Lohman TG, Roche AF, Matorell R. Anthropometric standartization reference manual. Illinois: Human Kinetics Books; 1998. p.3-70.

Salomon J, De Truchis P, Melchior JC. Nutrition and HIV infection. Br J Nutr. 2002; 87(Suppl 1):111-9. doi: 10.1079/bjn2001464.

American Dietetic Association. Position of the American Dietetic Association and Dietitians of Canada: nutrition intervention in the care of persons with human immunodeficiency virus infection. J Am Diet Assoc. 2004; 104(9):1425-41. doi: 10.1016/j.jada.2004.07.012.

Meininger G, Hadigan C, Rietschel P, Grinspon S. Body-composition measurements as predictors of glucose and insulin abnormalities in HIV positive men. Am J Clin Nutr. 2002; 76(2):460-5.

Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, et al. of fat redistribution and metabolic change in HIV infection (FRAM). fat distribution in men with HIV infection. J Acquir Immune Defic Syndr. 2005; 40(2):121-31.

Florindo AA, Latorre MRDO, Santos ECM, Borelli A, Rocha MS, Segurado AAC. Validação de métodos de estimativas da gordura corporal em portadores do HIV/Aids. Rev Saúde Pública. 2004; 38 (5):643-9. doi: 10.1590/S0034-89102004000500005.

Carr A, Samaras K, Burton S, Freund J, Chisholm DJ, Cooper DA. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS, 1998; 12(7):F51-F58.

Walli R, Herfort O, Michl G, Demant T. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1 infected patients. AIDS 1998; 12(15):F167-F173.

Lenhard JM, Croom DK, Weiel JE, Spaltenstein A. Dietary fat alters HIV protease inhibitor-induced mice. J Nutr. 2000; 130(9):2361-6.

Chen D, Misra A, Gard A. Lipodystrophy in Human Immunodeficiency virus-infected patients. J Clin Endocrinol Metab. 2002; 87(11):4845-56. doi: 10.1210/jc.2002-020794.

Published

2023-08-25

How to Cite

Rodrigues CURTI, M. L. ., Bellinghausen ALMEIDA, L. ., & Constante JAIME, P. (2023). Changes in the anthropometric parameters of patients with the Human Immunodeficiency virus or Acquired Immunodeficiency Syndrome: a prospective study. Brazilian Journal of Nutrition, 23(1). Retrieved from https://periodicos.puc-campinas.edu.br/nutricao/article/view/9335

Issue

Section

ORIGINAL ARTICLE