Lycopene as an antioxidant agent
Keywords:
Lycopene, antioxidants, free radicals, carotenoids, tomatoes, Lycopersicon esculentumAbstract
This paper is a review of scientific data about lycopene as an antioxidant agent. Lycopene is considered the carotenoid that has the highest capacity of capturing the singlet oxygen. Free radicals are continuously acting on the organism, being capable of promoting cellular damage and development of cancer among other chronic diseases. Studies show that lycopene protects lipid molecules, low-density lipoproteins, proteins and DNA against the attack of free radicals. They have an essential function in the protection against diseases. As a precaution, one should eat foods that are a source of lycopene: tomatoes and tomato-products (purée,
pasta, ketchup), papaya, pitanga and guava; to provide approximately 35mg of lycopene a day.
References
Méndez Filho JD, Rodríguez HGR. Sobre los benefícios de los radicales libres. Rev Med IMSS 1997; 35(4):309-13.
Speisky HC, Jiménez IT. Radicales libres y antioxidantes en la prevención de enfermidades III: evidencias clínico epidemiológicas de los riesgos y beneficios asociados al consumo de antioxidantes en la prevención de enfermidades cardiovasculares. Rev Chil Nutr 2000; 27(3): 314-25.
Papas AM. Diet and antioxidant status. Food Chem Toxicol 1999; 37:999-1007.
Halliwell B, Gutterdge JMC. Antioxidant defenses. In: Free radicals in biology and medicine. 3rd ed. Oxford: Clarenton Press; 1999. p.105-245.
Pool-Zobel BL, Bub A, Müller H, Wollowski I, Rechkemmer G. Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Carcinogenesis 1997; 18(9):1847-50.
Bianchi MLP, Antunes LMG. Radicais livres e os principais antioxidantes da dieta. Rev Nutr 1999; 12(2):123-30.
Silva CRM, Naves MMV. Suplementação de vitaminas na prevenção de câncer. Rev Nutr 2001; 14(2):135-43.
Agarwal S, Rao AV. Tomato lycopene and its role in human health and chronic diseases. Canad Med Assoc J 2000; 163(6):739-44.
Halliwell B, Gutterdge JMC. The chemistry of free radicals and, related ‘reactive species’. In: Free radicals in biology and medicine. 3rd ed. Oxford: Clarenton Press; 1999. p.36-104.
Anderson D. Antioxidant defences against reactive oxygen species causing genetic and other damage. Mut Res 2000; 350(1):103-8.
Ferreira ALA, Matsubara LS. Radicais livres: conceitos, doenças relacionadas, sistema de defesa e estresse oxidativo. Rev Assoc Med Bras 1997; 43(1):61-8.
Cooper KH. Revolução antioxidante. 2.ed. Rio de Janeiro: Record; 1996. p.29-38.
Lucesoli F, Fraga C. Evaluación del estres oxidativo. Antioxid Calid Vida 1995; 1(4):8-13.
Buzzini SRR, Matsudo VKR. Radicais livres, exercício e envelhecimento. Rev Bras Ciências Mov 1990; 4(4):61-85.
Halliwell B, Gutterdge JMC. Free radical, other reactive species and disease. In: Free radicals in biology and medicine. 3rd Oxford: Clarenton Press 1999. p.617-783.
Matés JM, Pérez-Gómez C, Castro IN. Antioxidant enzymes and human diseases. Clin Biochem 1999; 32(8):595-603.
Aust O, Sies H, Stahl W, Polidori MC. Analysis of lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids. J Chromatogr 2001; 936:83-93.
Handelman GJ. The evolving role of carotenoids in human biochemistry. Nutrition 2001; 17: 818-22.
Sies H, Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995; 62(6):1315-21.
Montero M. Los radicales libres y las defensas antioxidantes: revisión. Ann Fac Med 1996; 57(4):278-81.
Stahl W, Sies H. Carotenoids: occurrence, biochemical activities, and bioavailability. In: Packer L, Hiramatsu M, Yoshikawa T. Antioxidant food suplements in human health. San Diego: Academic Press; 1999. p.183-98.
Olson JA. Carotenoids and human health. Arch Latinoam Nutr 1999; 49(3 Suppl 1):7-11.
Erdman Jr JW, Variable bioavailability of carotenoids from vegetables. Am J Clin Nutr 1999; 70(2):179-80.
Di Mascio P, Kaiser S, Sies S. Lycopene as the most efficiente biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274(2):532-8.
Krinsky NI. Carotenoids as antioxidants. Nutrition 2001; 17:815-7.
Arab L, Steck S. Lycopene and cardiovascular disease. Am J Clin Nutr 2000; 71(6):1691-5.
Djuric Z, Powell LC. Antioxidant capacity of lycopene-containing foods. Int J Food Sci Nutr 2001; 52:143-9.
Takeoka GR, Dao L, Flessa S, Gillespie DM, Jewell WT, Huebner B, et al. Processing effects on lycopene content and antioxidant activity of tomatoes. J Agric Food Chem 2001; 49(8): 3713-7.
Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 1999; 91(4):317-31.
Gartner C, Stahl W, Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 1997; 66(1):116-22.
Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Erdman JW, Jr. Cis-trans lycopene isomers, carotenoids and retinol in the human prostate. Cancer Epidemiol 1996; 5:823-33.
Willcox JK, Catignani GL, Lazarus S. Tomatoes and cardiovascular health. Crit Rev Food Sci Nutr 2003; 43(1):1-18.
Boileau AC, Merchen NR, Wasson K, Atkinson CA, Erdman JW, Jr. Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in ymph-cannulated ferrets. J Nutr 1999; 129(6):1176-81.
Shi J, Maguer ML. Lycopene in tomatoes: chemical and physical properties affect by food processing. Crit Rev Biotech 2000; 20(4):293-334.
Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995; 87(3):1767-76.
Boileau TWM, Clinton SK, Erdman Jr JW. Tissue lycopene concentrations and isomer patterns are affected by androgen status and dietary lycopene concentration in male F344 rats. J Nutr 2000; 130:1613-8.
Willis MS, Wians Jr, FH. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin Chim Acta 2003; 330:57-83.
Shirai T, Asamoto M, Takahashi S, Imaida K. Diet and prostate cancer. Toxicology 2002; 181-2: 89-94.
Tucker G. Nutritional enhancement of plants. Curr Opin Biotechnnol 2003; 14:1-5.
Michaud DS, Feskanich D, Rinn EB, Colditz GA, Speizer FE, Willett WC, et al. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Am J Clin Nutr 2000; 72(4):990-7.
Heber D. Colorful cancer prevention: β-carotene, lycopene, and lung cancer. Am J Clin Nutr 2000; 72(4):901-2.
Bohm F, Tinkler JH, Truscott TG. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nat Med 1995; 1:98-9.
Stahl W, Sies H. Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys 1996; 336(1):1-9.
Rao AV, AGARWAL S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 1998; 31(3):199-203.
Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 2002; 113(9B):71S-88S.
Rao AV, Agarwal S. Role of antioxidant lycopene in câncer and heart disease. J Am Coll Nutr 2000; 19(5):563-9.
Rodriguez-Amaya DB. Latin american food sources of carotenoids. Arch Latinoam Nutr 1999; 49(3 Suppl 1):74-84.
Rao AV, Waseem Z, Agarwal S. Lycopene contents of tomatoes and tomato products and their contribution to dietary lycopene. Food Res Intl 1998; 31:737-41.
Programa de Apoio à Nutrição (NUT). Versão 2.5. CIS/EPM. São Paulo: UNIFESP; 1996.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Najua Juma Ismail Esh SHAMI, Emília Addison Machado MOREIRA
This work is licensed under a Creative Commons Attribution 4.0 International License.