Phenolic compounds profile, neuroprotective effect and antioxidant potential of a commercial Turkish coffee

Autores

  • Melek ÇOL AYVAZ Ordu University

Palavras-chave:

Anticholinesterase, Antioxidant effect, Free radicals, Lipid peroxidation

Resumo

Objective
The purpose of this study is to determine the phenolic and flavonoid contents, and antioxidant activities and neuroprotective effects of powdered coffee sample of a commercial coffee brand originated from Sivas, Turkey.
Methods
Total phenolic, flavonoid and antioxidant contents, enzymatic and non-enzymatic antioxidative activities based on 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity, metal chelating potential, reducing power, superoxide dismutase and catalase activity tests and lipid peroxidation inhibition potentials of the ethanolic and aqueous extracts of the coffee sample were assayed using the commonly preferred spectrophotometric methods. Furthermore the extracts’ cholinesterase and tyrosinase inhibition potentials were evaluated. Phenolic profiles of the coffee sample were investigated using high performance liquid chromatography.
Results
Catechin was the most frequently detected phenolic acid. In addition, it was demonstrated that the water extract has a significant impact when compared with standard antioxidants. While the SC50 (sufficient concentration to obtain 50% of a maximum scavenging capacity) value for the scavenging activity of 2,2-diphenyl-1-picrylhydrazyl free radical was calculated as being 0.08mg/mL for water extract, the amount of chelating agents with half Fe2+ ions in the medium was found to be 0.271mg/mL. Additionally, it was shown that 0.1mg/mL concentration of both extracts prevents lipid peroxidation by 8%. Compared with standard drugs, inhibition potentials of cholinesterase and tyrosinase enzymes were considered as moderately acceptable in these samples.

Conclusion
Besides the extracts’ enzymatic antioxidant activity, their inhibition potential on cholinesterase and tyrosinase enzymes – which are important clinical enzymes – reveal that this natural source can be used as a valuable resource in different fields, especially in medicine.

Referências

Özdestan Ö. Evaluation of bioactive amine and mineral levels in Turkish coffee. Food Res Int. 2014;61:167-75. http://dx.doi.org/10.1016/j.foodres.2013.12.027

Wachamo HL. Review on health benefit and risk of coffee consumption. Med Aromat Plants. 2017;6(4):1-12. http://dx.doi.org/10.4172/2167-0412.1000301

Wolska J, Janda K, Jakubczyk K, Szymkowiak M, Chlubek D, Gutowska I. Levels of antioxidant activity and fluoride content in coffee infusions of Arabica, robusta and green coffee beans in according to their brewing methods. Biol Trace Elem Res. 2017;179(2):327-33. http://dx.doi.org/10.1007/s12011-017-0963-9

Bedoya-Ramírez D, Cilla A, Contreras-Calderón J, Alegría-Torán A. Evaluation of the antioxidant capacity, furan compounds and cytoprotective/cytotoxic effects upon Caco-2 cells of commercial Colombian coffee. Food Chem. 2017;219:364-72. http://dx.doi.org/10.1016/j.foodchem.2016.09.159

Losada-Barreiro S, Bravo-Díaz C. Free radicals and polyphenols: the redox chemistry of neurodegenerative diseases. Eur J Med Chem. 2017;133:379-402. http://dx.doi.org/10.1016/j.ejmech.2017.03.061

Solfrizzi V, Panza F, Capurso A. The role of diet in cognitive decline. J Neural Transm. 2003;110(1):95-110. http://dx.doi.org/10.1007/s00702-002-0766-8

Prasanthi JRP, Dasari B, Marwarha G, Larson T, Chen X, Geiger JD, et al. Caffeine protects against oxidative stress and Alzheimer’s disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med. 2010;49(7):1212-20. http://dx.doi: 10.1016/j.freeradbiomed.2010.07.007

Nabavi SM, Talarek S, Listos J, Nabavi SF, Devi KP, Oliveira MR, et al. Phosphodiesterase inhibitors say NO to Alzheimer’s disease. Food Chem Toxicol. 2019;134:110822. http://dx.doi.org/10.1016/j.fct.2019.110822

Erdem SA, Senol FS, Budakoglu E, Orhan İE, Sener B. Exploring in vitro neurobiological effects and high pressure liquid chromatography-assisted quantitation of chlorogenic acid in 18 Turkish coffee brands. J Food Drug Anal. 2016;24(1):112-20. http://dx.doi.org/10.1016/j.jfda.2015.08.001

Tan X, Song YH, Park C, Lee KW, Kim JY, Kim DW, et al. Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking. Bioorg Med Chem. 2016;24(2):153-9. http://dx.doi.org/10.1016/j.bmc.2015.11.040

Chen MJ, Hung CC, Chen YR, Lai ST, Chan CF. Novel synthetic kojic acid-methimazole derivatives inhibit mushroom tyrosinase and melanogenesis. J Biosci Bioeng. 2016;122(6):666-72. http://dx.doi.org/10.1016/j.jbiosc.2016.06.002

Ahsan F, Bashir S. Coffee consumption: health perspectives and drawbacks. J Nutr Obes. 2019;2(1):1-4.

Camandola S, Plick N, Mattson MP. Impact of coffee and cacao purine metabolites on neuroplasticity and neurodegenerative disease. Neurochem Res. 2019;44(1):214-27. http://dx.doi: 10.1007/s11064-018-2492-0

Travassos M, Santana J, Baldeiras I, Tsolaki M, Gkatzima O, Sermin G, et al. Does caffeine consumption modify cerebrospinal fluid amyloid-b levels in patients with Alzheimer’s disease? J Alzheimers Dis. 2015;47(4):1069-78. http://dx.doi.org/10.3233/JAD-150374

Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009;16(1):85-91. http://dx.doi:10.3233/JAD-2009-0920

Kuçukomurler S, Ozgen L. Coffee and Turkish coffee culture. Pak J Nutr. 2009;8(10):1693-700. http://dx.doi.org./103923/pjn.2009.1693.1700

Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017;482(3):419-25. http://dx.doi.org/10.1016/j.bbrc.2016.10.086

Öztürk M, Tel G, Aydoğmuş Öztürk F, Duru ME. The cooking effect on two edible mushrooms in anatolia: fatty acid composition, total bioactive compounds, antioxidant and anticholinesterase activities. Rec Nat Prod. 2014;8(2):189-94.

Çol Ayvaz M. Phenolic profile and cholinesterase, tyrosinase, urease and lipid peroxidation inhibition potentials of artemisia argyi from Ordu, Turkey. Celal Bayar Uni J Sci. 2019;15(1):29-33. http://dx.doi.org/10.18466/cbayarfbe.430835

Kouassi KA, Kouadio EJP, Konan KH, Dué AD, Kouamé LP. Phenolic compounds, organic acid and antioxidant activity of Lactarius subsericatus, Cantharellus platyphyllus and Amanita rubescens, three edible ectomycorrhizal mushrooms from center of Côte d’Ivoire. Eurasian J Anal Chem. 2016;11(3):127-39. http://dx.doi.org/10.12973/ejac.2016.127a

Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolibdic-phosphotungtic acid reagents. Am J Enol Vitic. 1965;16(3):144-58.

Silva LAL, Pezzini BR, Soares L. Spectrophotometric determination of the total flavonoid content in Ocimum basilicum L. (Lamiaceae) leaves. Pharmacogn Mag. 2015;11(41):96-101. http://dx.doi.org/10.4103/0973-1 296.149721

Kasangana PB, Haddad PS, Stevanovic T. Study of polyphenol content and antioxidant capa city of Myrianthus arboreus (Cecropiaceae) root bark extracts. Antioxidants. 2015;4(2):410-26. http://dx.doi.org/10.3390/antiox4020410

Priftis A, Stagos D, Konstantınopoulos K, Tsıtsımpıkou C, Spandıdos DA, Tsatsakıs AM, et al. Comparison of antioxidant activity between green and roasted coffee beans using molecular methods. Mol Med Rep. 2015;12(5):7293-302. http://dx.doi.org/10.3892/mmr.2015.4377

Prıftıs A, Papıkınos K, Koukoulanakı M, Kerasıotı E, Stagos D, Konstantınopoulos K, et al. Development of an assay to assess genotoxicity by particulate matter extract. Mol Med Rep. 2017;15(4):1-9. http://dx.doi.org/10.3892/mmr.2017.6171

Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971;44(1):276-87. http://dx.doi.org/10.1016/0003-2697(71)90370-8

Keyhani J, Keyhani E. Anti-oxidative stress enyzmes in golden chanterelle (Cantharellus cibarius). In: Mendez-Vilas A, editor. Microbes in applied research. Singapore: World Scientific; 2012. p.23-7.

Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7(2):88-95. http://dx.doi.org/10.1016/0006-29 52(61)90145-9

Bozkurt B, Coban G, Kaya GI, Onur MA, Unver-Somer N. Alkaloid profiling, anticholinesterase activity and molecular modeling study of Galanthus elwesii. S Afr J Bot. 2017;113:119-27. http://dx.doi.org/10.1016/j.sajb.2017.08.004

Fajara BEP, Susanti H. HPLC determination of caffeine in coffee beverage. Proceedings of International Pharmacy Conference UAD on product authentication: key factor in quality control of pharmaceutical products; 2017 Sept 9; Yogyakarta, Indonesia. Bristol: IOP Publishing; 2017;259:012011. http://dx.doi.org/10.1088/1757-899X/259/1/012011.

Motora KG, Beyene TT. Determınation Of Caffeine In Raw and Roasted Coffee Beans Of Ilu Abba Bora Zone, South West Ethiopia. Indo Am J Pharm Res. 2017; 7(9):463-70. http://dx.doi.org/10.5281/zenodo.1036324

Köseoğlu Yılmaz P, Hacıbekıroğlu I, Kolak U. Effect of roasting on antioxidant and anticholinesterase capacities of coffee. J Food Nutr Res. 2014;53(3):232-9.

Stelmach E, Pohl P, Szymczycha-Madeja A. The content of Ca, Cu, Fe, Mg and Mn and antioxidant activity of green coffee brews. Food Chem. 2015;182:302-8. http://dx.doi.org/10.1016/j.foodchem.2015.02.105

Contreras-Calderón J, Mejía-Díaz D, Martínez-Castaño M, Bedoya-Ramírez D, López-Rojas N, Gómez-Narváez F, et al. Evaluation of antioxidant capacity in coffees marketed in Colombia: relationship with the extent of non-enzymatic browning. Food Chem. 2016;209:162-70. http://dx.doi.org/10.1016/j.foodchem.2016.04.038

Çol Ayvaz M. Antioxidant activity of Trachystemon orientalis (L.) G. Don (Borage) grown and eaten as food in Ordu, Turkey. Herba Pol. 2015;61(4):40-51. http://dx.doi.org/10.1515/hepo-2015-0030

Al Doghaither HA, Almowalad AM, Shorbaji AM, Al-Ghafari AB, Omar UM. Assessment of the antioxidant properties of the most common coffee brews available in the local markets of the Western region of Saudi Arabia. J Exp Biol Agric Sci. 2017;5(1):70-6. http://dx.doi.org/10.18006/2017.5(1).070.076

Fu R, Zhang Y, Guo Y, Lıu F Chen F. Determination of phenolic contents and antioxidant activities of extracts of Jatropha curcas L. seed shell, a by-product, a new source of natural antioxidant. Ind Crop Prod. 2014;58:265-70. http://dx.doi.org/10.1016/j.indcrop.2014.04.031

Iwai K, Kishimoto N, Kakino Y, Mochida K, Fujita T. In vitro antioxidative effects and tyrosine inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans. J Agric Food Chem. 2004;52(15):4893-8. http://dx.doi.org/10.1021/jf040048m

Watanabe T, Nakajima Y, Konishi T. In vitro and in vivo anti-oxidant activity of hot water extract of Basidiomycetes-X, newly identified edible fungus. Biol Pharm Bull. 2008;31(1):111-7.http://dx.doi.org/10.1248/bpb.31.111

Rengasamy KRR, Kulkarni MG, Stirk WA, Van Staden J. Advances in algal drug research with emphasis onenzyme inhibitors. Biotechnol Adv. 2014;32(8):1364-81. http://dx.doi.org/10.1016/j.biotechadv.2014.08.005

Oliveira-Neto JR, Rezende SG, Reis CF, Benjamin SR, Rocha ML, Gil ES. Electrochemical behavior and determination of major phenolic antioxidants in selected coffee samples. Food Chem. 2016;190:506-12. http://dx.doi.org/10.1016/j.foodchem.2015.05.104

Arendash GW, Cao C. Caffeine and coffee as therapeutics against Alzheimer’s disease. J Alzheimers Dis. 2010;20(S1):117-26. http://dx.doi.org/10.3233/JAD-2010-091249

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Publicado

20-09-2022

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ÇOL AYVAZ, M. . (2022). Phenolic compounds profile, neuroprotective effect and antioxidant potential of a commercial Turkish coffee. Revista De Nutrição, 33, 1–13. Recuperado de https://periodicos.puc-campinas.edu.br/nutricao/article/view/6861

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