Comparison of two diagnostic criteria for metabolic syndrome in adolescents and associations with subclinical atherosclerosis
Keywords:
Adolescent, Atherosclerosis, Cardiovascular diseases, Metabolic diseases, Metabolic syndromeAbstract
Objective
To compare two diagnostic criteria for metabolic syndrome in adolescents and to assess associations with subclinical atherosclerosis.
Methods
A cross-sectional study with a quantitative approach was carried out with 512 adolescents from public schools aged between 15 and 19 years in a municipality in northeast Brazil. The diagnostic criteria used for the metabolic syndrome were the International Diabetes Federation and the National Cholesterol Education Program, Adult Treatment Panel III, adapted by COOK.
Subclinical atherosclerosis was assessed through carotid intima-media complex thickness by ultrasound imaging.
Results
The diagnostic criteria for metabolic syndrome The National Cholesterol Education Program-Adult Treatment Panel III, adapted by COOK, identified a higher prevalence of young people with metabolic syndrome, 2.9%, was associated with subclinical atherosclerosis (p=0.02), had an of its components (elevated systemic blood pressure) associated with subclinical atherosclerosis
(p=0.030), presented a higher percentage of positive predictive value (PPV=15%), compared to the International Diabetes Federation criteria. The concordance index between the two diagnostic criteria for metabolic syndrome was low (kappa of 0.28, p<0.001).
Conclusion
In adolescents, the criterion of the National Cholesterol Education Program – Adult Treatment Panel III adapted by COOK, was the criterion presented better evaluations and was the only one that was associated with the presence of subclinical atherosclerosis when compared to the criteria of the International Diabetes Federation.
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Copyright (c) 2025 Renata Cardoso Oliveira, Danielle Franklin de Carvalho, Ivelise Fhrideraid Alves Furtado da Costa, Bruna Gabrielle de Araújo Silva, Iale Guilherme Araújo, Carla Campos Muniz Medeiros
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