Hormônios reguladores do apetite em mulheres obesas com e sem compulsão alimentar
Palavras-chave:
Grelina, Insulina, Obesidade, PYY 3-36, Transtorno de compulsão alimentarResumo
Objetivo
O objetivo deste estudo foi avaliar, antes e após a refeição, as concentrações séricas de hormônios ligados ao controle do apetite (peptídeo YY3-36, grelina total, leptina e insulina) em mulheres obesas com e sem episódios de compulsão alimentar e compará-las às mulheres de peso normal.
Métodos
Vinte e cinco mulheres com idade entre 32 e 50 anos foram convidadas a participar deste estudo, incluindo 9 mulheres com peso normal (20-25kg/m2) sem episódios de compulsão alimentar (grupo 1), 9 mulheres obesas (u30 kg/m2) com episódios de compulsão alimentar (grupo 2) e 7 mulheres obesas sem episódios de compulsão alimentar (grupo 3). Foram coletadas quatro amostras de sangue pós-prandiais a 60 minutos (1 hora antes), bem como 15, 45 e 90 minutos após uma refeição composta de 55% de carboidratos, 15% de proteínas e 30% de lipídeos.
Resultados
O maior HOMA-IR foi observado no grupo 3 (M=2,5, DP=1,04) quando comparado ao grupo 1 (M=1,5, DP=0,53) e ao grupo 2 (M=1,8, DP=0,58), p=0,04. O índice de massa corporal (p<0,0001), a leptina (p<0,0001) e a insulina (p=0,01) foram maiores no grupo 3 antes e após a refeição. A grelina total (p=0,003) e o PYY3-36 (p=0,02) foram menores no grupo 2 antes e após a refeição. Após o ajuste do índice de massa corporal, apenas a baixa concentração de PYY3-36 no grupo 2 manteve-se estatisticamente diferente entre os grupos (p=0,01).
Conclusão
Este estudo sugere que níveis baixos do PYY-3-36 estejam associados à compulsão alimentar em mulheres obesas.
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Copyright (c) 2023 Paula Paraguassú BRANDÃO, Érica Patrícia GARCIA-SOUZA, Fabiana Alves NEVES, Mário José dos Santos PEREIRA, Rosely SICHIER, Aníbal Sanchez MOURA
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