Ácidos graxos trans: implicações nutricionais e fontes na dieta
Palavras-chave:
ácidos graxos trans, doenças cardiovasculares, fontes na dieta, dietaResumo
Este artigo revisa as principais fontes de ácidos graxos trans na dieta e as implicações nutricionais da ingestão elevada destes isômeros. São apresentados resumidamente os métodos analíticos utilizados na identificação e quantificação dos ácidos graxos trans, sendo abordados as suas vantagens e desvantagens. Os alimentos que empregam gordura parcialmente hidrogenada na sua produção, são fontes importantes de isômeros trans na dieta da maior parte da população em países industrializados. Este estudo compara os níveis de ácidos graxos trans em gorduras hidrogenadas, margarinas e batatas frita, analisados em diversos países, incluindo o Brasil. Esta avaliação indica a presença de níveis elevados de isômeros trans em alimentos produzidos no Brasil.
Referências
Feldman EB, Krisetherton P, Kritchevsky D, Lichtenstein AH. Position paper on trans fatty acids. Am J Clin Nutr 1996; 63(5):663-70.
Basso R, Almeida IG, Mancini JF. Avaliação qualitativa e quantitativa dos ácidos graxos trans em gorduras vegetais hidrogenadas. Bol SBCTA 1999; 33(1):57-63.
Anderson JT, Grande F, Keys A. Hidrogenated fats in the diet and lipids in the serum man. J Nutr 1961; 75(4):388-94.
Katan MB, Mensink RP, Zock PL. Trans fatty acids and their effect on lipoproteins in humans. Annu Rev Nutr 1995; 15(5):473-93.
Mensink RP, Katan MB. Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 1990; 323(7):439-45.
Zock PL, Katan MB. Hydrogenation alternatives: effects of trans fatty acids and stearic acids versus linoleic acid on serum lipids and lipoproteins in humans. J Lipid Res 1992; 33(10):399-410.
Judd JT, Clevidence BA, Muesing RA, Wittes J, Sunkin ME, Podczasy JJ. Dietary trans fatty acids: effects of plasma lipids and lipoproteins on healthy men and women. Am J Clin Nutr 1994; 59(4): 861-8.
Aro A, Jauhiainen M, Partanen R, Salminen I, Mutanen M. Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein, lipids apolipoproteins, lipoprotein(a), and lipid transfer proteins in health subjects. Am J Clin Nutr 1997; 65(5):1419-26.
Sundram K, Ismail A, Hayes KC, Jeyamalar R, Pathmanathan R. Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific satured fatty acids in humans. J Nutr 1997; 127(3):514s-20s.
Muller H, Jordal O, Seljeflot I, Kierulf P, Kirkhus E, Ledsaak O, et al. Effect on plasma lipids and lipoproteins of replacing partially hydrogenated fish oil with vegetable fat in margarine. Br J Nutr 1998; 80(3):243-51.
Lichtenstein AH, Ausman LM, Jalbert SM, Schaefer EJ. Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 1999; 340(25): 1933-40.
Ascherio A, Katan MB, Zock, PL, Stampfer, MJ, Willett WC. Trans fatty acids and coronary heart disease. N Engl J Med 1999; 340(25):1994-8.
Stampfer MJ, Sacks, FM, Salvini S, Willett WC, Hennekens CH. A prospective-study of cholesterol, apolipoproteins, and the risk of myocardial-infarction. N Engl J Med 1991; 325(6):373-81.
Hu FB, Manson JE, Willett WC. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 2001; 20(1):5-19.
Nestel P, Noakes M, Belling B, Mcarthur R, Clinfton P, Janus E, et al. Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet. J Lipid Res 1992; 33(78):1029-36.
Mensink RP, Zock PL, Katan MB, Hornstra G. Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. J Lipid Res 1992; 33(10):1493-501.
Lichtenstein AH, Ausman LM, Carrasco W, Jenner JL, Ordovas JM, Schaefer EJ. Hydrogenation impairs the hypolipidemic effect of corn oil in humans, trans fatty acids and plasma-lipids. Arterioscler Thromb 1993; 13(2):154-61.
Lippi G, Guidi G. Biochemical risk factors and patient’s outcome: The case of lipoprotein(a). Clin Chim Acta 1999; 280(1):59-71.
Dahlen GH. Lp(a) lipoprotein in cardiovascular disease. Atherosclerosis 1994; 108(2):111-26.
Hornstra GA, van Houwelingen AC, Kester DM, Sundram K. A palm-oil-enriched diet lowers serum lipoprotein[a] in normocholesterolemic volunteers. Atherosclerosis 1991; 90(1):91-3.
Judd JT, Baer DJ, Clevidence BA, Muesing RA, Chen SC, Weststrat JA, et al. Effects of margarine compared with those of butter on blood lipid profiles related to cardiovascular disease risk factors in normolipemic adults fed controlled diets. Am J Clin Nutr 1998; 68(4):768-77.
Kirstein D, Hoy CE, Holmer G. Effect of dietary fats on the delta-6-desaturation and delta-5-desaturation of fatty-acids in rat-liver microsomes. Br J Nutr 1983; 50(3):749-53.
Mahfouz MM, Smith TL, Kummerow, FA. Effect of dietary fats on desaturase activities and the biosynthesis of fatty-acids in rat-liver microsomes. Lipids 1984; 19(3):214-22.
Blond JP, Henchiri C, Precigou P, Grandgirar DA, Sebedio JL. Effect of 18-3 n-3 geometrical-isomers of heated linseed oil on the biosynthesis of arachidonic-acid in rat. Nutr Res 1990; 10(1): 69-79.
Decsi T, Koletzko B. Do trans fatty acids impair linoleic acid metabolism in children? Ann Nutr Metab 1995; 39(1):36-41.
Scrimgeour CM, Macvean A, Fernie C, Sebedio JL, Riemersma AR. Dietary trans linolenic acid does not inhibit and desaturation of linoleic acid in man. Eur J Lipid Sci Technol 2001; 103(6):341-349.
Ledoux M, Laloux L, Wolff R. Analytical methods for determination of trans-C18 fatty acids isomers in milk fat. A review. Analusis 2000; 28(5):402-12.
Seppanen-Laakso T, Laakso I, Hiltunen R. Analysis of fatty acids by gas chromatography, and its relevance to research on health and nutrition. Anal Chim Acta 2002, 465(1-2):39-62.
Christie WW. Gas chromatography and lipids. Glasgow: The Oily Press; 1994. 307p.
Bysted A, Cold S, Holmer G. An optimized method for fatty acid analysis, including quantification of trans fatty acids, in human adipose tissue by gas-liquid chromatography. Scand J Clin Lab Invest 1999; 59(3):205-14.
Ratnayake WMN, Hollywood R, O’Grady E, Beare-Rogers JL. Determination of cis and trans- -octadecenoic acids in margarines by gas liquid chromatography-infrared espectrophotometry. J Am Oil Chem Soc 1990; 67(11):804-10.
Favier JP, Bicanic D, van de Bovenkamp P, Chirtoc M, Helander P. Detection of total trans fatty acids content in margarine: an intercomparison study of GLC, GLC+TLC, FT-IR, and optothermal window (open photoacoustic cell). Anal Chem 1996; 68(5):729-33.
Ratnayake WMN. Determination of trans unsaturation by infrared spectrophotometry and determination of fatty acid composition of partially hidrogenated vegetable oils and animals fats by gas chromatography/infrared spectrofotmetry: collaborative study. J Assoc Off Anal Chem 1995; 78(3):783-802.
Larque E, Zamora S, Gil A. Dietary trans fatty acids in early life: a review. Early Hum Dev 2001; 65(2):31s-41s.
Aro A, van Amelsvoort Becker W, van Erp-Baart MA, Kafatos A, Leth T, van Poppel, G. Trans fatty acids in dietary fats and oils from 14 European Countries: The TRANSFAIR study. J. Food Comp Anal 1998; 11(2):137-49.
Dionisi F, Golay PA, Fay LB. Influence of milk fat presence on the determination of trans fatty acids in fats used for infant formulae. Anal Chim Acta 2002; 465(1):395-407.
Azevedo CH. Teores de isômeros trans em gorduras vegetais hidrogenadas avaliadas por diferentes técnicas instrumentais [dissertação]. Campinas: Faculdade de Engenharia de Alimentos, Unicamp; 1999.
Soares LMV, Franco MRB. Níveis de trans-isômeros e composição de ácidos graxos de margarinas e produtos hidrogenados semelhantes. Ciênc Tecnol Aliment 1990; 10(1):57-71.
Santana DMN, Marques MM, Rosa CAR. Determinação por cromatografia gasosa da composição em ácidos graxos e teor de ácido trans oléico em algumas marcas de batata frita. Bol SBCTA 1999, 33(1):64-9.
Chiara VL, Sichieri R. Food consumption of adolescents. A simplified questionnaire for evaluating cardiovascular risk. Arq Bras Cardiol 2001; 77(4):337-41.
Tavella M, Peterson G, Espeche M, Cavallero E, Cipolla L, Perego L, Caballero B. Trans fatty acid content of a selection of foods in Argentina. Food Chem 2000; 69(2):209-13.
Mansour MP, Sinclair AJ. The trans fatty acid and positional (sn-2) fatty acid composition of some Australian margarines, dairy blends and animal fats. Asia Pac J Clin 1993; 4(2):155-63.
Lake R, Thomson B, Devane G, Scholes P. Trans fatty acid content of selected New Zealand Foods. J Food Comp Anal 1996; 9(4):365-74.
Wagner KH, Auer E, Elmadfa I. Content of trans fatty acids in margarines, plant oils, fried products and chocolate spreads in Austria. Eur Food Res and Technol 2002; 214(2):208-11.
Torres D, Casal S, Oliveira MBPP. Fatty acid composition of Portuguese spreadable fats with emphasis on trans isomers. Eur Food Res and Technol 2000; 210(4):237-41.
Enig MG, Pallansch LA, Sampugna J, Keeney M. Fatty acid composition of the fat in selected food items with emphasis on trans components. J Am Oil Chem Soc 1983; 60(10):1788-95.
Slover HT, Thompson JR, Davis CS, Merola GV. Lipids in margarines and margarine-like foods. J Am Oil Chem Soc 1990; 62(4):775-86.
Innis SM, Green TJ, Halsey TK. Variability in the trans fatty acid content of foods within a food category: implications for estimation of dietary trans fatty acids intakes. J Am Coll Nutr 1999; 18(3):255-60.
Katan MB. Exit trans fatty acids. Lancet 1995; 346:1245-6.
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Copyright (c) 2023 Clayton Antunes MARTIN, Makoto MATSHUSHITA, Nilson Evelázio de SOUZA
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