VITAMINA K: METABOLISMO E NUTRIÇÃO
Palavras-chave:
vitamina K, filoquinona, disponibilidade biológica, metabolismo, nutriçãoResumo
O objetivo desta revisão foi discutir aspectos que envolvem a compreensão do metabolismo da vitamina K e os recentes avanços quanto ao papel da vitamina na nutrição humana. São abordadas questões sobre as fontes da vitamina, sua absorção, distribuição e metabolismo, recomendações dietéticas, avaliação do estado nutricional relacionado à vitamina K e ainda fatores que afetam sua concentração plasmática. Diante das novas evidências sobre a participação da vitamina K no metabolismo ósseo, pesquisas adicionais são necessárias a fim de identificar as possíveis conseqüências à saúde, a longo prazo, de deficiência subclínica desta vitamina. Pesquisadores e comitês futuros encontram um desafio no que se refere a investigar novos requerimentos nutricionais da vitamina.
Referências
ALLISON, P.M., MUMMAH-SCHENDEL, L.L., KINDBERG, C.G., HARMS, C.S., BANG, N.U., SUTTIE, J.W. Effects of a vitamin K-deficient diet and antibiotics in normal human volunteers. Journal of Laboratory Clinical Medicine, St. Louis, v.110, n.2, p.180-188, 1987.
ANDREW, M., PAES, B., MILNER, R. Development of the human coagulation system in the full-term infant. Blood, Duluth, v.70, n.1, p.165-172, 1987. ANONYMOUS. Vitamin K, vitamin E and the coumarin drugs. Nutrition Reviews, New York, v. 40, n.6, p.180-182, 1982.
BACH, A.U., ANDERSON, S.A., FOLEY, A.L., WILLIAMS, E.C. , SUTTIE, J.W. Assessment of vitamin K status in human subjects administered “minidose” warfarin. American Journal of Clinical Nutrition, Bethesda, v.64, n.6, p.894-902, 1996.
BERKNER, K.L. The vitamin K-dependent carboxylase. Journal of Nutrition, Bethesda, v.130, n.8, p.1877-1880, 2000.
BOOTH, S.L., SADOWSKI, J.A., WEIHRAUCH, J.L., FERLAND, G. Viatmin K1 (phylloquinone) content of foods: a provisional table. Journal of Food Composition and Analysis, Blacksburg, v.6, p.109-120, 1993.
BOOTH, S.L., MADABUSHI, H.T., DAVIDSON, K.W. , SADOWSKI, J.A. Tea and coffee brews are not dietary sources of vitamin K-1 (phylloquinone). Journal of the American Dietetic Association, Chicago, v.95, n.1, p.82-83, 1995a.
BOOTH, S.L., SOKOLL, L.J., O’BRIEN, M.E., TUCKER, K., DAWSONHUGHES, B., SADOWSKI, J.A. Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. European Journal of Clinical Nutrition, London, v.49, n.11, p.832-841, 1995b.
BOOTH, S.L., PENNINGTON, J.A., SADOWSKI, J.A. Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. Lipids, Champaign, v.31, n.7, p.715-720, 1996a.
BOOTH, S.L., PENNINGTON, J.A., SADOWSKI, J.A. Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. Journal of the American Dietetic Association, Chicago, v.96, n.2, p.149-154, 1996b.
BOOTH, S.L., TUCKER, K.L., McKEOWN, N.M., DAVIDSON, K.W., DALLAL, G.E., SADOWSKI, J.A. Relationships between dietary intakes and fasting plasma concentrations of fat-soluble vitamins in humans. Journal of Nutrition, Bethesda, v.127, n.4, p.587-592, 1997.
BOOTH, S.L. , SUTTIE, J.W. Dietary intake and adequacy of vitamin K. Journal of Nutrition, Bethesda, v.128, n.5, p.785-788, 1998.
BOOTH, S.L., TUCKER, K.L., CHEN, H., HANNAN, M.T., GAGNON, D.R., CUPPLES, L.A., WILSON, P.W.F., ORDOVAS, J., SCHAEFER, E.J., DAWSON-HUGHES, B., KIEL, D.P. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. American Journal of Clinical Nutrition, Bethesda, v.71, n.5, p.1201-1208, 2000.
CAMILO, M.E., PAIVA, S.A.R., O’BRIEN, M., BOOTH, S.L., DAVIDSON, K.W., SOKOLL, L., SADOWSKI, J.A., RUSSELL, M.R. The interaction between vitamin K nutriture and warfarin administration in patients with bacterial overgrowth due to atrophic gastritis. The Journal of Clinical Nutrition Health and Aging, v.2, n.2, p.716-721, 1998.
CANFIELD, L.M., HOPKINSON, J.M. State of the art vitamin K in human milk. Journal of Pediatric Gastroenterology and Nutrition, New York, v.8, n.4, p.430-441, 1989.
CARLIN, A., WALKER, W.A. Rapid development of vitamin K deficiency in an adolescent boy receiving total parenteral nutrition following bone narrow transplantation. Nutrition Reviews, New York, v.49, n.6, p.179-183, 1991.
DAVIDSON, K.W., BOOTH, S.L., DOLNIKOWSKI, G.G., SADOWSKI, J.A. Conversion of vitamim K1 to 2',3'-dihydrovitamin K1 during the hydrogenation of vegetable oils. Journal of Agricultural and Food Chemistry, Washington DC, v.44, p.980-983, 1996.
DAVIDSON, K.W., SADOWSKI, J.A. Determination of vitamin K compounds in plasma or serum by HPLC using post colum chemical reduction and fluorometric detection. In: McCORNICK, D.B., SUTTIE, J., WAGNER, C. (Ed.). Vitamins and coenzymes: methods in enzymology. San Diego : Academic Press, 1997. p.408-421.
DÔRES, S.M.C., FREITAS Jr. I.F., PAIVA, S.A.R., MAFFEI, F.H.A., CAMPANA, A.O. Estimativa da ingestão usual e fontes dietéticas de vitamina K1 em pacientes ambulatoriais. In: CONGRESSO LATINO-AMERICANO DE NUTRIÇÃO, 12., 2000, Buenos Aires. Anais... Buenos Aires, 2000. p.EN-33.
DOWD, P., HERSHLINE, R., HAM, S.W., NAGANATHAN, S. The mechanism of action of vitamin K. Annual Review of Nutrition, Palo Alto, v.15, p.419-440, 1995.
DUELLO, T.J., MATSCHINER, J.T. Identification of phylloquinone in horse liver. Archives of Biochemistry and Biophysics, New York, v.138, n.2, p.640-645, 1970.
FENTON, S.T., PRICE, R.J., BOLTON-SMITH, C., HARRINGTON, D., SHEARER, M.J. Nutrient sources of phylloquinone in Scottish men and women. Proceedings of the Nutrition Society, London, v.56, p.301, 1997.
FERLAND, G., SADOWSKI, J.A. The vitamin K1 (phylloquinone) content of edible oils: effects of heating and light exposure. Journal of Agricultural and Food Chemistry, Washington DC, v.40, p.1869-1873, 1992.
FERLAND, G., SADOWSKI, J.A, O’BRIEN, M.E. Dietary induced subclinical vitamin K deficiency in normal human subjects. Journal of Clinical Investigation, New York, v.91, n.4, p.1761-1768, 1993.
GABER, A.K., BINKLEY, N.C., KRUEGER, D.C., SUTTIE, J.W. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. Journal of Nutrition, Bethesda, v.129, n.6, p.1201-1203, 1999.
GIJSBER, B.L.; VAN HAARLEN L.J.M; EBBERINK, R.H; VERMEER, C. Caracterization of a Gla containing protein from calcified human atherosclerotic plaques. Artherosclerosis, Dallas, v.10, n.6, p.991-995, 1990.
GIJSBERS, B.L., JIE, K.S. , VERMEER, C. Effect of food composition on vitamin K absorption in human volunteers. British Journal of Nutrition, London, v.76, n.2, p.223-229, 1996.
GUERRA, C.C.C., ROSENFELD, L.G.M. Coagulação e anticoagulantes. In: MAFFEI, F.H.A., LASTÓRIA, S., YOSHIDA, W.B., ROLLO. Doenças vasculares periféricas. [s.l] : Médica Científica, 1995. p.47-65.
HIRAUCHI, K., SAKANO, T., NOTSUMOTO, S., NAGAOKA, T., MORIMOTO, A., FUJIMOTO, K., MASUDA, S. , SUZUKI, Y. Measurement of K vitamins in animal tissues by high-performance liquid chromatography with fluorimetric detection. Journal of Chromatography, Amsterdam, v.497, p.131-137, 1989.
HODGES, S.J., BEJUI, J., LECLERCQ, M., DELMAS, P.D. Detection and measurement of vitamins K1 and K2 in human cortical and trabecular bone. Journal of Bone Mineral Research, New York, v.8, n.8, p.1005-1008, 1993.
KINDBERG, C.G., SUTTIE, J.W. Effect of various intakes of phylloquinone on signs of vitamin K deficiency and serum and liver phylloquinone concentrations in the rat. Journal of Nutrition, Bethesda, v.119, n.2, p.175-180, 1989.
KNAPEN, M.J., HAMULYÁK, K., VERMEER, M.H.J. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Annual Internal Medicine, v.111, n.12, p.1001-1005, 1989.
KOHLMEIER, M., SALOMON, A., SAUPE, J., SHEARER, M.J. Transport of vitamin K to bone in humans. Journal of Nutrition, Bethesda, v.126, n.4, p.1192S-1196S, 1996. Supplement.
KOHLMEIER, M., SAUPE, J., DROSSEL, H.J., SHEARER, M.J. Variation of phylloquinone (vitamin K1) concentrations in hemodialysis patients. Thrombosis Haemostasis, Stuttgart, v.74, n.5, p.1252-1254, 1995.
LAMON-FAVA, S., SADOWSKI, J.A., DAVIDSON, K.W., O’BRIEN, M.E., McNAMARA, J.R., SCHAEFER, E.J. Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans. American Journal of Clinical Nutrition, Bethesda, v.67, n.6, p.1226-1231, 1998.
LANE, PA., HATHAWAY, W.E. Vitamin K in infancy. Journal of Pediatrics, St. Louis, v.106, n.3, p.351-359, 1985.
LANGENBERG, J.P., TJADEN, U.R., De VOGEL, E.M., LANGERAK, D.I. Determination of vitamin K1 in raw and processed vegetables using reversed phase HPLC with electrofluorometric detection. Acta Alimentaria, v.15, n.3, p.187-198, 1986.
MIJARES, M.E., NAGY, E., GUERRERO, B., AROCHA-PIÑANGO, C.L. La vitamina K: bioquímica, función y deficiencias. Revisión. Investigation Clinics, v.39, n.3, p.213-229, 1998.
OLSON, R.E. The function and metabolism of vitamin K. Annual Review of Nutrition, Palo Alto, v.4, p.281-337, 1984.
OLSON, R.E. Vitamin K. In: SHILS, M.E., A. OLSON, J.A., SHIKE, M. Modern nutrition in health and disease. [s.l] : Lea & Febiger, 1994. p.342-358.
OLSON, R.E. Vitamin K. In: SHILS, M.E., OLSON, J.A., SHIKE, M., ROSS, A.C. Modern nutrition in health and disease. Baltimore : Williams & Wilkins, 1999. p.363-380.
OLSON, R.E. Osteoporosis and vitamin K intake. American Journal of Clinic Nutrition, Bethesda, v.71, p.1031-1032, 2000.
PAIVA, S.A., SEPE, T.E., BOOTH, S.L., CAMILO, M.E., O’BRIEN, M.E., DAVIDSON, K.W., SADOWSKI, J.A., RUSSELL, R.M. Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. American Journal of Clinical Nutrition, Bethesda, v.68, n.3, p.699-704, 1998.
SADOWSKI, J.A., HOOD, S.J., DALLAL, G.E., GARRY, P.J. Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. American Journal of Clinical Nutrition, Bethesda, v.50, n.1, p.100-108, 1989.
SADOWSKI, J.A., BOOTH, S.L., MANN, K.M., MALHOTRA, O., BOVILL, E.G. Structure and mechanism of activation of vitamin K antagonist. In: POLLER, L., HIRSH, J. Oral anticoagulants. New York : Arnold, 1996.
SAKANO, T., NOTSUMOTO, M., NAGAOKA, T., MORIMOTO, A., FUJIMOTO, K., MASUDA, S., SUZUKI, Y., HIRAUCHI, K. Measuraments of K vitamins by highperformance liquid chromatography with fluorometric detection. Vitamins, Kyoto, v.62, p.393-398, 1988.
SHEARER, M.J., McBURNEY, A., BARKHAN, P. Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man. Vitamins and Hormones, New York, v.32, p.513-542, 1974.
SHEARER, M.J., BECHTOLD, H., ANDRASSY, K., KODERISCH, J., McCARTHY, P.T., TRENK, D., JAHNCHEN, E., RITZ, E. Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status. Journal of Clinical Pharmacology, Hagerstown, v.28, n.1, p.88-95, 1988.
SHEARER, M.J. Vitamin K. Lancet, London, v.345, n.8944, p.229-234, 1995.
SHEARER, M.J., BACH, A., KOHLMEIER, M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. Journal of Nutrition, Bethesda, v.126, n.4, p.1181S-1186S, 1996. Supplement.
SOKOLL, L., O’BRIEN, M., CAMILO, M., SADOWSKI, J. Undercarboxylated osteocalcin and development of a method to determine vitamin K status. Clinical Chemistry, Washington DC, v.41, n.8, p.1121-1128, 1995.
SOKOLL, L.J., BOOTH, S.L., O’BRIEN, M.E., DAVIDSON, K.W., TSAIOUN, K.I., SADOWSKI, J.A. Changes in serum osteocalcin, plasma phylloquinone and urinary gamma- carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. American Journal of Clinical Nutrition, Bethesda, v.65, n.3, p.779-784, 1997.
SOKOLL, L.J., SADOWSKI, J.A. Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. American Journal of Clinical Nutrition, Bethesda, v.63, n.4, p.566-573, 1996.
SUTTIE, J.W. Vitamin K and human nutritrion. Journal of the American Dietetic Association, Chicago, v.92, n.5, p.585-590, 1992.
SUTTIE, J.W. The importance of menaquinones in human nutrition. Annual Review of Nutrition, Palo Alto, v.15, p.399-417, 1995.
SUTTIE, J.W. Vitamin K. In: ZIEGLER, E.E., FILER Jr. L.J. Present knowledge in nutrition. Washington : ILSI Press, 1996. p.137-145.
SUTTIE, J.W., MUMMAH-SCHENDEL, L.L., SHAH, D.V., LYLE, B.J., GREGER, J.L. Vitamin K deficiency from dietary vitamin K restriction in humans. American Journal of Clinical Nutrition, Bethesda, v.47, n.3, p.475-480, 1988.
SZULC, P., CHAPUY, M.C., MEUNIER, P.J., DELMAS, P.D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone, v.18, n.5, p.719-724, 1996.
THIJSSEN, H.H., DRITTIJ-REIJNDERS, M.J. Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4. British Journal of Nutrition, London, v.75, n.1, p.121-127, 1996.
USUI, Y., TANIMURA, H., NISHIMURA, N., KOBAYASHI, N., OKANOUE, T., OZAWA, K. Vitamin K concentrations in the plasma and liver of surgical patients. American Journal of Clinical Nutrition, Bethesda, v.51, n.5, p.846-852, 1990.
VERMEER, C., GIJSBERS, B.L., CRACIUN, A.M., GROENEN-VAN DOOREN, M.M., KNAPEN, M.H. Effects of vitamin K on bone mass and bone metabolism. Journal of Nutrition, Bethesda, v.126, n.4, p.1187S-1191S, 1996. Supplement.
VERMEER, C., HAMULYAK, K. Pathophysiology of vitamin K-deficiency and oral anticoagulants. Thrombosis Haemostasis, Stuttgart, v.66, n.1, p.153-159, 1991.
VERMEER, C., JIE, K.S., KNAPEN, M.H. Role of vitamin K in bone metabolism. Annual Review of Nutrition, Palo Alto, v.15, p.1-22, 1995.
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Copyright (c) 2023 Sílvia Maria Custódio das DÔRES, Sérgio Alberto Rupp de PAIVA, Álvaro Oscar CAMPANA
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