Efeitos da suplementação com zinco sobre o crescimento, sistema imunológico e diabetes
Palavras-chave:
crescimento, diabetes, sistema imunológico, suplementação, zincoResumo
O zinco apresenta funções catalíticas, estruturais e reguladoras, sendo componente de várias enzimas. Os sintomas observados na deficiência deste elemento incluem lesões de pele, anorexia, retardo do crescimento, hipogonadismo e alteração na função imune. O objetivo desta revisão foi apresentar as funções metabólicas e funcionais do zinco, enfatizando as conseqüências da deficiência e os aspectos que justificam os estudos envolvendo a suplementação com zinco e seus efeitos sobre o crescimento, sistema imunológico e diabetes. Considerando que algumas doenças predispõem o organismo à deficiência de zinco, a suplementação, isoladamente ou associada a outros elementos, demonstra benefícios, especialmente no aumento da velocidade de crescimento, funcionamento do sistema imunológico, diminuição das afecções respiratórias e controle das diarréias. A suplementação em pacientes com diabetes está relacionada com as variáveis do controle metabólico e as concentrações plasmáticas e eritrocitárias de zinco. As estratégias de suplementação com zinco, em populações de risco, devem ser implementadas, considerando-se as doses adequadas de ingestão.
Referências
McCall KA, Huang CC, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr. 2000; 130(5):1437S-46.
Salgueiro MJ, et al. Zinc as an essencial micronutrient: a review. Nutr Res. 2000; 20(5): 737-55.
Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr. 1996; 15(2):113-20.
Hambidge, M. Biomarkers of trace mineral intake status. J Nutr. 2003; 133(3 Suppl):948S-55.
Food and Agriculture Organization. World Health Organization. Human vitamin and mineral requirements. Report of a joint FAO/WHO expert consultation. Bangkok; 2002. p. 257-70.
National Academy of Sciences, Food and Nutrition Board, Institute of Medicine (USA) - Dietary Reference Intakes (DRI) for vitamin A, vitamin K, Arsenic, Boron, Chromium, Cooper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC.; 2001. 650p.
Allen LH. Zinc and micronutrient supplements for children. Am J Clin Nutr. 1998; 68(2):485S.
MacDonald RS. The role of zinc in growth and cell proliferation. J Nutr. 2000; 130(5):1500S-8S.
Ghavami-Maibodi SZ, Collip PJ, Castro-Magana M, Stewart C, Chen SY. Effect of oral zinc supplements on growth, hormonal levels, and zinc in healthy short children. Ann Nutr Metabol. 1983; 27(3):214-9.
Nakamura T, Nishiyama S, Futagoishi-Suginohara Y, Matsuda I, Higashi A. Mild to moderate zinc deficiency in short children: effect of zinc supplementation on linear-growth velocity. J Pediatr. 1993; 123(1):65-9.
Brown KH, Peerson JM, Allen LH. Effect of zinc supplementation on children’s growth: A meta-analysis of intervention trials. Bibl Nutr Dieta. 1998; 54(1):76-83.
Kikafunda JK, Walker AF, Allan EF, Tumwine JK. Effect of zinc supplementation on growth and body composition of Ugandan preschool children: a randomized controlled, intervention trial. Am J Clin Nutr. 1999; 70(1):110-3.
Rivera JA, Ruel MT, Santizo MC, Lönnerdal B, Brown KH. Zinc supplementation improves the growth of stunted rural Guatemalan infants. J Nutr. 1998; 128(3):556-62.
Castillo-Duran C, Garcia H, Venegas P, Torrealba I, Panteon E, Concha N, et al. Zinc supplementation in very-slow-growth velocity of male children adolescents with short stature. Acta Pediatric. 1994; 83(8):833.
Friel JK, Andrews WL, Matthew JD, Long DR, Cornel AM, Cox M, et al. Zinc supplementation in very-low-birth-weight infants. J Pediatr Gastroenterol Nutr. 1993; 17(1):97-103.
Salgueiro MJ, Zubillaga MB, Lysionek AE, Sarabia MI, Caro RA, De Paoli T, et al. Zinc status and immune system relationship: A review. Biol Trace Elem Res. 2000; 76(3):193-205.
Fraker PJ, King LE, Laakko T, Vollmer TL. The dynamic link between the integrity of the immune system and zinc status. J Nutr. 2000; 130(5 Suppl): 1399S-406.
Sazawal S, Jalla S, Mazumder S, Sinha A, Black RE, Bahan MK. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subjects in preschool children. Indian Pediatr. 1997; 37(7): 589-97.
Prasad AS, Beck FW, Kaplan J, Chandrasekar PH, Ortega J, Fitzgerald JT, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol. 1999; 61(3):194-202.
Coovadia HM, Bobat R. Zinc deficiency and supplementation in HIV/AIDS. Nutr Res. 2002; 22(1-2):179-91.
Chevalier P, Sevilla R, Zalles L, Sejas E. Effect of zinc supplementation on nutritional immune deficiency. Nutr Res. 1994; 16(3):369-79.
Salgueiro MJ, Krebs N, Zubillaga MB, Weill R, Postaire E, Lysionek AE, et al. Zinc and diabetes mellitus: is there a need of zinc supplementation in diabetes mellitus patientes? Biol Trace Elem Res. 2001; 81(3):215-28.
Cunningham JJ, Fu A, Mearkle L, Brown G. Hiperzincuria in individuals with Insulin-Dependent Diabetes mellitus: concurrent zinc status and effect of high-dose zinc supplementation. Metabolism. 1994; 43(12): 1558-62.
Sena KCM, Pedrosa LFC. Efeito da suplementação oral de zinco em crianças e adolescentes com diabetes tipo 1 [dissertação]. Natal: Universidade Federal do Rio Grande do Norte; 2002.
Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM. Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur J Clin Nutr. 1995; 49(4):282-8.
Rauscher AM, Fairweather-Tait SJ, Wilson PD, Gorrick WS, Greenwood R. Zinc metabolism in non-insulin dependent diabetes mellitus. J Trace Elem Med Biol. 1997; 11(2):65-70.
Tobia MH, Zalanowicz MM, Wingertzahn MA, McHeffey-Atkinson B, Slovim AE, et al. The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wistar rat. Mol Gen Metabol. 1998; 63(3):205-13.
Ho E, Quan N, Tsai YH, Lai W, Bray TM. Dietary zinc supplementation inhibits NFκB activation and protects against chemically induced diabetes in CD1 mice. Proc Soc Exp Biol Med. 2001; 226(2):103-11.
Simon SF, Taylor CG. Dietary zinc supplementation attenuates hyperglycemia in db/db mice. Proc Soc Exp Biol Med. 2001; 226(1):43-51.
Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheu JM, Kerkeni A. Potencial antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr. 2001; 20(3):212-18.
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Copyright (c) 2023 Karine Cavalcanti Maurício de SENA, Lucia de Fátima Campos PEDROSA
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