O papel dos hormônios leptina e grelina na gênese da obesidade

Autores

  • Carla Eduarda Machado ROMERO Universidade Estadual Paulista
  • Angelina ZANESCO Universidade Estadual Paulista

Palavras-chave:

hipotálamo, leptina, metabolismo, obesidade, tecido adiposo

Resumo

A prevalência da obesidade está aumentando e estudos prospectivos mostram que, em 2025, o Brasil será o quinto país do mundo a apresentar problemas de obesidade em sua população. A etiologia da obesidade não é de fácil identificação, uma vez que a mesma é caracterizada como uma doença multifatorial, ou seja, diversos fatores estão envolvidos em sua gênese, incluindo fatores genéticos, psicológicos, metabólicos e ambientais. Pesquisas recentes na área de metabolismo mostram que o adipócito é capaz de sintetizar várias substâncias e, diferentemente do que se supunha anteriormente, o tecido adiposo não é apenas um sítio de armazenamento de triglicérides, é hoje considerado um órgão endócrino. Dentre as diversas substâncias sintetizadas pelo adipócito, destacam-se a adiponectina, a angiotensina e a leptina. A leptina é um petídeo que desempenha importante papel na regulação da ingestão alimentar e no gasto energético, gerando um aumento na queima de energia e diminuindo a ingestão alimentar. Além dos avanços no estudo da célula adiposa, um novo hormôrnio relacionado ao metabolismo foi descoberto recentemente, a grelina. A grelina é um peptídeo produzido nas células do estômago, e está diretamente envolvida na regulação do balanço energético a curto prazo. Assim, este artigo abordará o papel da leptina e da grelina no controle do peso corporal e as limitações que ainda existem para tratar a obesidade em  humanos.

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Publicado

20-09-2023

Como Citar

Machado ROMERO, C. E. ., & ZANESCO, A. (2023). O papel dos hormônios leptina e grelina na gênese da obesidade. Revista De Nutrição, 19(1). Recuperado de https://periodicos.puc-campinas.edu.br/nutricao/article/view/9800

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