Desnutrição protéica no início da vida prejudica memória social em ratos adultos
Palavras-chave:
desnutrição protéica, comportamento social, ratosResumo
Objetivo
Avaliar se a desnutrição protéica imposta no início da vida produz prejuízos em um procedimento experimental de memória social em ratos (Rattus norvegicus).
Métodos
Os animais receberam dietas isocalóricas contendo 6% ou 16% de proteína do nascimento aos 21 dias, e dieta comercial a partir de 22 dias de idade. O teste de memória social consistiu em, após duas sessões de habituação (7 minutos/sessão), introduzir um animal adulto (100-114 dias de idade) e um outro jovem (30-44 dias de idade) em uma arena de acrílico (90cm x 90cm x 45cm) em duas sessões separadas por intervalos de 30 (experimento 1) ou 15 minutos (experimento 2). O contato social foi definido como investigação (ato de cheirar/inspecionar a região anogenital). A diferença no tempo de contato entre a primeira e a segunda exposição é considerada um índice de memória social.
Resultados
Nenhuma diferença devida à dieta foi observada no experimento 1. No experimento 2 houve redução no tempo de contato social dos animais-controle da primeira para a segunda exposição (p<0,05) e não houve alteração nos animais desnutridos.
Conclusão
Esses resultados sugerem que a desnutrição protéica precoce prejudica a memória social de ratos adultos.
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