Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica
Palavras-chave:
Citocinas, Estresse oxidativo, Inflamação, Resistência à insulina, Selênio, Síndrome metabólicaResumo
O estado inflamatório crônico e de baixo grau bem como o estresse oxidativo associados à síndrome metabólica são fatores de risco relevantes para o desenvolvimento de doenças cardiovasculares. Neste contexto, o selênio é um mineral essencial que se encontra associado com o correto funcionamento dos principais processos metabólicos celulares. Estudos in vitro e in vivo em modelos experimentais de síndrome metabólica, bem como em humanos, tem investigado o efeito do selênio sobre a expressão e secreção de biomarcadores de inflamação e de estresse oxidativo. Para obtenção dos artigos sobre efeitos antioxidantes do selênio foram feitas pesquisas nos websites científicos. Na literatura encontramos numerosos artigos sobre os diferentes parâmetros modulados pelas concentrações plasmáticas de selênio, incluindo a proteína-C reativa, a interleucina-6, o fator de necrose tumoral-α, a interleucina-1β e a proteína transportadora de retinol-4. Esta revisão teve por objetivo discutir o papel do selênio nos processos inflamatórios e de estresse oxidativo, associados à síndrome metabólica.
Referências
Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III) Final report. Circulation. 2002; 106(25):3143-421.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome. Circulation. 2005; 112(17):2735-52.
Dandona P, Chaudhuri A, Ghanim H, Mohanty P. Proinflammatory effects of glucose and antiinflammatory effects of insulin: relevance to cardiovascular disease. Am J Cardiol. 2007; 99 (Suppl):15B-26B.
Francisco G, Hernández C, Simó R. Serum markers of vascular inflammation in dyslipidemia. Clin Chim Acta. 2006; 369(1):1-16.
Yudkin JS, Juhan-Vague I, Hawe E, Humphries SE, Di Minno G, Margaglione M, et al. The HIFMECH Study Group. Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH Study. Metabolism. 2004; 53(7):852-7.
Festa A, D‘Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance
syndrome. Circulation. 2000; 102(1):42-7.
Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, et al. AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of The American Heart Association. Circulation. 2000; 102 (18):2284-99.
Walston J, Xue Q, Semba RB, Ferrucci L, Cappola AR, Ricks M, et al. Serum antioxidants, inflammation, and total mortality in older women. AJE. 2006; 163(1):18-26.
Wells BJ, Mainous AG III, Everett CJ. Association between dietary arginine and C-reactive protein. Nutrition. 2005; 21(2):125-30.
Sinatra ST, De Marco J. Free radicals, oxidative stress, oxidized low density lipoprotein (LDL) and the heart: antioxidants and other strategies to limit cardiovascular damage. Conn Med. 1995; 59(10): 579-88.
Rayman MP. The importance of selenium to human health. Lancet. 2000; 356(15):233-41.
Alissa EM, Bahijri SM, Ferns GA. The controversy surrounding selenium and cardiovascular disease: a review of the evidence. Med Sci Monit. 2003; 9(1):9-18.
González S, Huerta JM, Álvarez-Uría J, Fernández S, Patterson AM, Laceras C. Serum selenium is associated with plasma homocysteine concentrations in elderly humans. J Nutr. 2004, 134(7):1736-40.
Virtamo J, Valkeila E, Alfthan G, Punsar S, Huttunen JK, Karvonen MJ. Serum selenium and the risk of coronary heart disease and stroke. Am J Epidemiol. 1985; 122(2):276-82.
Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation. 2004; 109(1): 2-10.
Ross R. Atherosclerosis: an inflammatory disease. New Engl J Med. 1999; 340(2):115-26.
Abdellaoui A, Al-Khaffaf H. C-reactive protein (CRP) as a marker in peripheral vascular disease. Eur J Vasc Endovasc Surg. 2007; 20(5):1-5.
Rexrode KM, Pradhan A, Mansos JE, Buring JE, Ridker PM. Relationship of total and abdominal adiposity with CRP and IL-6 in women. Ann Epidemiol. 2003; 13(10):1-9.
Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E. Metabolic syndrome and C-reactive protein in the general population - JMS Cohort Study. Circ J. 2007; 71(1):26-31.
Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr. 2003; 57(9):1157-63.
Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endotelial dysfunction: a potencial role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999; 19(4):972-8.
Hung J, McQuillan BM, Chapman CML, Thompson PL, Beilby JP. Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance. Arterioscler Thromb Vasc Biol. 2005; 25(6):1268-73.
Volpato S, Guralnik JM, Ferrucci P, Balfour J, Chaves P, Fried LP, et al. Cardiovascular disease, interleukin6, and risk of mortality in older women: the Women’s Health and Aging Study. Circulation. 2001; 103(7):947-53.
Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999; 106: 506-12.
Rayman MP. The importance of selenium to human health. Lancet. 2000; 356(9225):233-41.
Klotz LO, Kroncke KD, Buchczyk DP, Sies H. Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr. 2003; 133(1):1448S-51S.
Kunsch C, Medford RM. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res. 1999; 85(8):753-66.
de Haan JB, Cristiano F, Iannello R, Bladier C, Kelner MJ, Kola I. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet. 1996; 5(2):283-92.
de Haan JB, Cristiano F, Iannello RC, Kola I. Cu/Znsuperoxide dismutase and glutathione peroxidase during aging. Biochem Mol Biol Int. 1995; 35(6): 1281-97.
Zhang J, Johnston G, Stebler B, Keller ET. Hydrogen peroxide activates NF-κβ and the interleukin-6 promoter through NF-κβ inducing kinase. Antioxid Redox Signal. 2001; 3(3):493-504.
Ruan H, Lodish HF. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alfa. Cytokine Growth Rev. 2003; 14(5): 447-55.
Montague CT, Prins JB, Sanders L, Zhang J, Sewter CP, Digby J, et al. Depot: related gene expression in human subcutaneous and omental adipocytes. Diabetes. 1998; 47(9):1384-90.
Klein J, Perwitz Z, Kraus D, Fasshauer M. Adipose tissue as source and target for novel therapies. Trends Endocrinol Metab. 2006; 17(1):1-7.
Zhang F, Yu W, Hargrove JL, Greenspan P, Dean RG, Taylor EW, et al. Inhibition of TNF-α induced ICAM-1, VCAM-1 and E-selectin expression by selenium. Atherosclerosis. 2002; 161(2):381-6.
Winkler G, Kiss S, Ketszthelyi L, Sapi Z, Ory I, Salamon F, et al. Expression of tumor necrosis factor (TNF-alfa) protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alfa, soluble serum TNF-receptor-2 concentrations and C-peptide level. Eur J Endocrinol. 2003; 149(2):129-35.
Arner P. Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med. 1995; 27(7):435-8.
Hsueh WA, Law R. The central role of fat and effect of peroxisome proliferator-activated and cardiovascular disease. Am J Cardiol. 2003; 92(1): 3-9.
Lassalle P, Gosset P, Delneste Y, Tsicopoulos A, Capron A, Joseph M, et al. Modulation of adhesion molecule expression on endothelial cells during the late asthmatic reaction: role of macrophage-derived tumour necrosis factor-alpha. Clin Exp Immunol. 1993; 94(1):105-10.
Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, Liebenthal C, et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 2000; 102(25): 3060-7.
Horváthová M, Jahnová E, Gazdík F. Effect of selenium supplementation in asthmatic subjects on the expression of endothelial cell adhesion molecules in culture. Biol Trace Elem Res. 1999; 69(1):15-26.
Zheng HT, Zhou LN, Huang CJ, Hua X, Jian R, Su BH, et al. Selenium inhibits high glucose- and high insulin-induced adhesion molecule expression in vascular endotelial cells. Arch Med Res. 2008; 39(4):373-9.
Brigelius-Flohé R, Banning A, Kny M, Bol GF. Redox events in interleukin-1 signaling. Arch Biochem Biophys. 2004; 423(1):66-73.
Brigelius-Flohé R, Friedrichs B, Maurer S, Schultz M, Streicher R. Interleukin-1 induced nuclear factor κβ activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line. Biochem J. 1997; 328(Pt 1):199-203.
Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappa beta activation in insulin-producing cells. Diabetes. 2003; 52(1):93-101.
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005; 436(7049): 356-62.
Zulet MA, Puchau B, Navarro C, Martí A, Martínez JA. Biomarcadores del estado inflamatorio: Nexo de unión con la obesidad y complicaciones asociadas. Nutr Hosp. 2007; 22(5): 511-27.
Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007; 90(3):338-44.
Shin MJ, Kang SM, Jang Y, Lee JH, Oh J, Chung JH, et al. Serum retinol binding protein 4 levels are associated with serum adiponectin levels in nondiabetic, non-obese subjects with hypercholesterolemia. Clin Chim Acta. 2007; 378(1-2):227-9.
Hermsdorff HHM, Zulet Alzórriz MA, Lecea BP, Bressan J, Martínez Hernández JA. La dieta y el estilo de vida condicionan los niveles de la adipoquina RBP4 en población adulta joven: Posible asociación con el estado oxidativo. Rev Esp Obes. 2007; 5(5):281.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Ana Carolina Pinheiro VOLP, Josefina BRESSAN, Helen Hermana Miranda HERMSDORFF, María Ángeles ZULET, José Alfredo MARTÍNEZ
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
