Potenciais riscos de saúde relacionados com ingredientes de suplementos alimentares de pré-treino e pós-treino: análise meticulosa de rótulos

Autores

  • João Nuno Alves do Vale Marques FP-I3ID, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa. Porto, Porto, Portugal https://orcid.org/0000-0001-9340-1783
  • João Paulo Capela UCIBIO, REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto,

Palavras-chave:

Suplementos Nutricionais, Doping, Ciências da Nutrição, Toxicidade

Resumo

Objetivo
O uso de suplementos alimentares está a aumentar. Estes podem conter altas doses de substâncias ou combinações de ingredientes perigosas. Este artigo procura encontrar, analisando os rótulos dos produtos, se existem substâncias dopantes ou nocivas. 

Métodos
Foram analisadas várias marcas cujos respectivos suplementos foram classificados em pré e pós-treino. Foram incluídos 40 suplementos com todos os ingredientes descritos. A respectiva dose mínima e máxima foi descrita estatisticamente como média ± DP.
Resultados
Extratos de Citrus aurantium, Yohimbe, Garcinia cambogia e raiz de Maca foram encontrados nos suplementos analisados. O grupo pré-treino apresentou maior média de cafeína (241±86mg) do que o grupo pós-treino (183±68mg), e a dose média mínima foi de 226±84mg, enquanto a dose média máxima foi de 242±88 mg. O grupo pré-treino apresentou menor média de creatina (3106±1079mg) do que o grupo pós-treino (4137±4177mg), e a dose média mínima foi de 3167±1728mg, enquanto a dose média máxima foi de 3917±3643mg. O grupo pós-treino apresentou uma maior média de sal (2155±4486mg) do que o grupo pré-treino (464±605mg), e a dose média mínima foi 1635±3930mg, enquanto a dose média máxima foi de 1708±3926mg.
Conclusão
Não foram encontradas substâncias dopantes nos suplementos, mas algumas recomendações de consumo nos rótulos poderão levar à sobredose de certos ingredientes menos testados.

Referências

Garthe I, Maughan RJ. Athletes and supplements: Prevalence and perspectives. Int J Sport Nutr Exerc Metab. 2018;28(2):126-38.

World Anti-doping Agency. 2013 Anti-Doping Rule Violations (ADRVs) Report. 2015, Montreal, Canada.

World Anti-doping Agency. 2017 Anti-Doping Rule Violations (ADRVs) Report. 2019, Montreal, Canada.

Tsarouhas K, Kioukia-Fougia N, Papalexis P, Tsatsakis A, Kouretas D, Bacopoulou F, et al. Use of nutritional supplements contaminated with banned doping substances by recreational adolescent athletes in Athens, Greece. Food Chem Toxicol. 2018;115:447-50. https://doi.org/10.1016/j.fct.2018.03.043

Martínez-Sanz JM, Sospedra I, Ortiz CM, Baladía E, Gil-Izquierdo A, Ortiz-Moncada R. Intended or unintended doping? A review of the presence of doping substances in dietary supplements used in sports. Nutrients. 2017;9(10):1-22.

Helle C, Sommer A, Syversen P, Lauritzen F. Doping substances in dietary supplements. Tidsskr Den Nor Legeforening. 2019 [cited 2020 Jun 21];139(4). Available from: www.supplement411.org

Outram S, Stewart B. Doping through supplement use: a review of the available empirical data. Int J Sport Nutr Exerc Metab. 2015;25(1):54-9.

La Gerche A, Brosnan MJ. Cardiovascular effects of performance-enhancing drugs. Circulation. 2017 Jan 3 [cited 2020 Jun 21];135(1):89-99. Available from: https://pubmed.ncbi.nlm.nih.gov/28028062/

Mudrak J, Slepicka P, Slepickova I. Sport motivation and doping in adolescent athletes. Plos One. 2018 [cited 2020 Jun 21];13(10). Available from: https://pubmed.ncbi.nlm.nih.gov/30286200/

Group A. Australian Institute of Sport. [cited 2020 Mar 28]. Available from: https://ais.gov.au/nutrition/supplements/tiles/group_d

Van Breemen RB, Fong HHS, Farnsworth NR. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008;87(2):509-13.

Sprouse AA, Van Breemen RB. Pharmacokinetic interactions between drugs and botanical dietary supplements. Drug Metab Dispos. 2016;44(2):162-71.

Alves M, Capela J. Dietary supplements for weight loss with synephrine: risks and toxicity. 2019;16(16):36-46.

Gutiérrez-Hellín J, Del Coso J. Effects of p -synephrine and caffeine ingestion on substrate oxidation during exercise. Med Sci Sports Exerc. 2018;50(9):1899-906.

Haller CA, Benowitz NL, Jacob P. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med. 2005;118(9):998-1003.

Stohs S. Safety, efficacy, and mechanistic studies regarding citrus aurantium (bitter orange) extract and p-synephrine. Phyther Res. 2017;31(10):1463-74.

Shara M, Stohs SJ, Smadi MM. Safety evaluation of p-synephrine following 15 days of oral administration to healthy subjects: A clinical study. Phyther Res 2018 [cited 2020 Jun 21];32(1):125-31. Available from: https://pubmed.ncbi.nlm.nih.gov/29130542/

Schmitt GC, Arbo MD, Lorensi AL, Jacques ALB, Nascimento SN, Mariotti KC, et al. Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine. Brazilian J Pharm Sci. 2016;52(1):59-68. https://doi.org/10.1590/S1984-82502016000100007

Arbo MD, Schmitt GC, Limberger MF, Charão MF, Moro ÂM, Ribeiro GL, et al. Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice. Regul Toxicol Pharmacol. 2009;54(2):114-7.

Schmitt GC, Arbo MD, Lorensi AL, Maciel ÉS, Krahn CL, Mariotti KC, et al. Toxicological effects of a mixture used in weight loss products: P-synephrine associated with ephedrine, salicin, and caffeine. Int J Toxicol. 2012 [cited 2021 Jun 22];31(2):184-91. Available from: http://ijt.sagepub.com

Rossato LG, Costa VM, Limberger RP, Bastos ML, Remião F. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011;49(1):8-16. https://doi.org/10.1016/j.fct.2010.11.007

Chen P, Bryden N. Determination of yohimbine in yohimbe bark and related dietary supplements using UHPLC-UV/MS: Single-laboratory validation. J AOAC Int. 2015;98(4):896-901.

Tam SW, Worcel M, Wyllie M. Yohimbine: A clinical review. Pharmacol Ther. 2001;91(3):215-43.

Semwal RB, Semwal DK, Vermaak I, Viljoen A. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia. 2015;102:134-48. https://doi.org/10.1016/j.fitote.2015.02.012

Haber S, Awwad O, Phillips A, Park A, Pham T. Garcinia Cambogia: safe for weight loss? Am J Heal Pharm. 2018 [cited 2020 Jun 21];75(2):17-22. Available from: http://www.webmd.com/vitamins-and-supplements/garcinia-cambogiaweight-loss#1

Yu JS, Choi MS, Park JS, Rehman SU, Nakamura K, Yoo HH. Inhibitory effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity. Planta Med. 2017;83(11):895-900.

Sharma A, Akagi E, Njie A, Arsene C, Krishnamoorthy G, Ehrinpreis M. Acute hepatitis due to garcinia cambogia, an herbal weight loss supplement. Case Reports Gastrointest Madicines. 2018;112:S1288.

Antidopagem M, Rebelo P. Lista de Substâncias e Métodos Proibidos. 2019;1-13.

Krentz AJ, Fujioka K, Hompesch M. Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles. Diabetes Obes Metab. 2016;18(6):558-70.

Pickering C, Kiely J. Are the current guidelines on caffeine use in sport optimal for everyone? Inter-individual variation in caffeine ergogenicity, and a move towards personalised sports nutrition. Sport Med. 2018;48(1):7-16.

Trexler ET, Smith-Ryan AE. Creatine and caffeine: considerations for concurrent supplementation. Int J Sport Nutr Exerc Metab. 2015;25(6):607-23.

Southward K, Rutherfurd-Markwick KJ, Ali A. The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sport Med. 2018;48(8):1913-28. https://doi.org/10.1007/s40279-018-0939-8

Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The safety of ingested caffeine: a comprehensive review. Front Psychiatry. 2017;8(80):1-19.

Lopes M, Capela J. Study on the composition of thermogenic food supplements containing caffeine available in Portugal. Assoc Port Nutr. 2017;10(10):24-36.

Crisafulli DL, Buddhadev HH, Brilla LR, Chalmers GR, Suprak DN, San Juan JG. Creatine-electrolyte supplementation improves repeated sprint cycling performance: a double blind randomized control study. J Int Soc Sports Nutr. 2018;15(21):1-11.

Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14(1):1-18.

Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Inter Soc Sports Nutr.; 2021;18:1-17. https://doi.org/10.1186/s12970-021-00412-w

Hall M, Trojian TH. Creatine supplementation. Curr Sports Med Rep. 2013 Jul;12(4):240-4.

Jagim AR, Stecker RA, Harty PS, Erickson JL, Kerksick CM. Safety of creatine supplementation in active adolescents and youth: a brief review. Front Nutr. 2018;5(115):1-13.

Rust P, Ekmekcioglu C. Impact of salt intake on te pathogenesis and treatment of hypertension. Advs Exp Med Biol Respir. 2016;10:61-84.

Slifman N, Obermeyer W, Musser S, Correl W, Joseph S, Love L. Contamination of botanical dietary supplements by digitalis lanata. N Engl J Med. 1998;339(12):806-11.

Sharma A, Akagi E, Njie A, Goyal S, Arsene C, Krishnamoorthy G, et al. Acute hepatitis due to garcinia cambogia extract, an herbal weight loss supplement. Case Rep Gastrointest Med. 2018;2018:1-4.

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Publicado

01-03-2023

Como Citar

Marques, J. N. A. do V., & Capela, J. P. (2023). Potenciais riscos de saúde relacionados com ingredientes de suplementos alimentares de pré-treino e pós-treino: análise meticulosa de rótulos. Revista De Nutrição, 35, 1–12. Recuperado de https://periodicos.puc-campinas.edu.br/nutricao/article/view/7492

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ARTIGOS ORIGINAIS