Riscos dos suplementos alimentares para emagrecer contendo sinefrina e cafeína disponíveis em Portugal

Autores

  • Catarina Martins Cepêda FP3ID, Universidade Fernando Pessoa, Faculdade de Ciências da Saúde. https://orcid.org/0009-0004-9202-1403
  • João Paulo Capela FP3ID, Universidade Fernando Pessoa, Faculdade de Ciências da Saúde; UCIBIO, Universidade do Porto, Faculdade de Farmácia; Laboratório Associado i4HB - Instituto de Saúde e Bioeconomia, Universidade do Porto, Faculdade de Farmácia. https://orcid.org/0000-0003-2607-1264

Palavras-chave:

Cafeína, Citrus aurantium, Suplementos nutricionais, Sinefrina, Toxicidade, Perda de peso

Resumo

Objetivo
Cafeína e sinefrina são normalmente incluídas em produtos para perda de peso devido aos alegados efeitos termogénicos. Neste estudo foi avaliada a quantidade de cafeína e sinefrina encontrada em suplementos alimentares disponíveis em sítios da internet que enviam para Portugal. Além disso, investigou-se se essas quantidades estão de acordo com as recomendações das autoridades de saúde e alimentares.
Métodos
Este estudo observacional realizou uma busca em sítios da internet que vendem suplementos desportivos, nos quais foram analisados os rótulos. Os critérios de inclusão foram suplementos que continham sinefrina e cafeína, independentemente da quantidade e do uso. Os critérios de exclusão foram suplementos que continham apenas um dos componentes e aqueles cujas quantidades dos ingredientes não estavam discriminadas no rótulo.
Resultados
Foram encontrados 20 suplementos alimentares, os quais possuíam sinefrina na forma de extrato de laranja amarga (Citrus aurantium). Foi encontrada uma mediana de 153 mg (IC 95%: 40-334) para o extrato. Os níveis medianos estimados de sinefrina foram 11 mg (IC 95%: 6-20). Relativamente à cafeína, a mediana foi de 200 mg (IC 95%: 176-250), embora o valor possa ser mais elevado dada a presença de várias fontes vegetais de cafeína. Além disso, 65% dos suplementos excedem os limites recomendados pelo Instituto Federal Alemão de Avaliação dos Riscos para a sinefrina e 30% apresentam mais de 200 mg de cafeína.
Conclusão
Dessa forma, foi possível concluir que 65% e 30% dos suplementos alimentares excedem as quantidades recomendadas pelas autoridades de segurança alimentar de sinefrina e cafeína, respetivamente, o que poderá colocar em risco a saúde do consumidor.

Referências

Gutierrez-Hellin J, Aguilar-Navarro M, Ruiz-Moreno C, Munoz A, Amaro-Gahete FJ, Posada-Ayala M, et al. Effect of p-Synephrine on Fat Oxidation Rate during Exercise of Increasing Intensity in Healthy Active Women. Nutrients. 2022;14(20):4352. doi: https://doi.org/10.3390/nu14204352

Gutierrez-Hellin J, Del Coso J. Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise. Med Sci Sports Exerc. 2018;50(9):1899-906. doi: https://doi.org/10.1249/MSS.0000000000001653

Guest NS, VanDusseldorp TA, Nelson MT, Grgic J, Schoenfeld BJ, Jenkins NDM, et al. International society of sports nutrition position stand: caffeine and exercise performance. J Int Soc Sports Nutr. 2021;18(1):1. doi: https://doi.org/10.1186/s12970-020-00383-4

Clark NW, Wells AJ, Coker NA, Goldstein ER, Herring CH, Starling-Smith TM, et al. The acute effects of thermogenic fitness drink formulas containing 140 mg and 100 mg of caffeine on energy expenditure and fat metabolism at rest and during exercise. J Int Soc Sports Nutr. 2020;17(1):10. doi: https://doi.org/10.1186/s12970-020-0341-4

Rodak K, Kokot I, Kratz EM. Caffeine as a factor influencing the functioning of the human body-friend or foe? Nutrients. 2021;13(9):3088. doi: https://doi.org/10.3390/nu13093088

Agostoni C, Canani RB, Fairweather-Tait S, Heinonen M, Korhonen H, La Vieille S, et al. Scientific Opinion on the safety of caffeine. Efsa J. 2015;13(5):4102. doi: https://doi.org/10.2903/j.efsa.2015.4102

Ruiz-Moreno C, Del Coso J, Giraldez-Costas V, Gonzalez-Garcia J, Gutierrez-Hellin J. Effects of p-Synephrine during exercise: a brief narrative review. Nutrients. 2021;13(1):233. doi: https://doi.org/10.3390/nu13010233

Rossato LG, Costa VM, Limberger RP, Bastos ML, Remiao F. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011;49(1):8-16. doi: https://doi.org/10.1016/j.fct.2010.11.007

Fernández-Cabal J, Avilés-Betanzos KA, Cauich-Rodríguez JV, Ramírez-Sucre MO, Rodríguez-Buenfil IM. Recent developments in citrus aurantium L.: an overview of bioactive compounds, extraction techniques, and technological applications. Processes. 2025;13(1):120. doi: https://doi.org/10.3390/pr13010120

Gutierrez-Hellin J, Baltazar-Martins G, Rodriguez I, Lara B, Ruiz-Moreno C, Aguilar-Navarro M, et al. p-Synephrine, the main protoalkaloid of Citrus aurantium, raises fat oxidation during exercise in elite cyclists. Eur J Sport Sci. 2021;21(9):1273-82. doi: https://doi.org/10.1080/17461391.2020.1817154

Stohs SJ, Ratamess NA. Effects of p-synephrine in combination with caffeine: a review. Nutr Diet Suppl. 2017;9:87-96. doi: https://doi.org/10.2147/Nds.S144761

Direção Geral de Alimentação e Veterinária. Suplementos alimentares – DGAV 2025. Lisboa: DGAV; 2025 [cited 2025 Mar 6]. Available from: https://www.dgav.pt/alimentos/conteudo/generos-alimenticios/regras-especificas-por-tipo-de-alimentos/suplementos-alimentares/

The Business Research Company. Weight Loss Supplements Global Market Report 2023. United Kingdom: TBRC; 2023 [cited 2024 Jul 15]. Available from: https://www.thebusinessresearchcompany.com/report/weight-loss-supplements-global-market-report

Marques JNAV, Capela JP. Potential health risks surrounding ingredients of pre-workout and postworkout dietary supplements: a thorough label analysis. Rev Nutr. 2022;35:e200148. doi: https://doi.org/10.1590/1678-9865202235e200148

Bundesinstitut für Risikobewertung. Health assessment of sports and weight loss products containing synephrine and caffeine. Germany: Bundesinstitut für Risikobewertung; 2012. Report No.: BfR Opinion No. 004/2013.

Canada H. Guidelines for the use of synephrine in natural health products Canada: Health Canada; 2010 [cited 2024 Jul 15]. Available from: https://www.canada.ca/en/health-canada/services/drugs-healthproducts/natural-non-prescription/legislation-guidelines/guidance-documents/notice-use-synephrine.html

Canada H. Synephrine, Octopamine and Caffeine, Health Risk Assessment (HRA) Repor. Canada; 2011. Report No.: 172091.

ANSES. Dietary supplements for weight loss containing p-synephrine France: ANSES; 2014 [cited 2024 Jul 15]. Available from: https://www.anses.fr/en/content/dietary-supplements-weight-loss-containingp-synephrine

Benjamim CJR, Junior FWS, Porto AA, Rocha EMB, Santana MD, Garner DM, et al. Bitter orange (Citrus aurantium L.) Intake before submaximal aerobic exercise is safe for cardiovascular and autonomic systems in healthy males: a randomized trial. Front Nutr. 2022;9:890388. doi: https://doi.org/10.3389/fnut.2022.890388

Stohs SJ, Ray SD. Review of published bitter orange extract and p-synephrine adverse event clinical study case reports. J Diet Suppl. 2020;17(3):355-63. doi: https://doi.org/10.1080/19390211.2019.1577936

de Jonge MLL, Kieviet LC, Sierts M, Egberink LB, van der Heyden MAG. Review of case reports on adverse events related to pre-workout supplements containing synephrine. Cardiovasc Toxicol. 2023;23(1):1-9. doi: https://doi.org/10.1007/s12012-022-09777-z

Kliszczewicz B, Bechke E, Williamson C, Green Z, Bailey P, McLester J, et al. Citrus Aurantium and caffeine complex versus placebo on biomarkers of metabolism: a double blind crossover design. J Int Soc Sports Nutr. 2019;16(1):4. doi: https://doi.org/10.1186/s12970-019-0271-1

Ratamess NA, Bush JA, Stohs SJ, Ellis NL, Vought IT, O’Grady EA, et al. Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: a placebo-controlled, double-blind study. Phytother Res. 2018;32(1):94-102. doi: https://doi.org/10.1002/ptr.5953

Haller CA, Duan M, Jacob P, 3rd, Benowitz N. Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol. 2008;65(6):833-40. doi: https://doi.org/10.1111/j.1365-2125.2008.03144.x

Cohen PA, Avula B, Katragunta K, Travis JC, Khan I. Presence and quantity of botanical ingredients with purported performance-enhancing properties in sports supplements. JAMA Netw Open. 2023;6(7):e2323879. doi: https://doi.org/10.1001/jamanetworkopen.2023.23879

Walpurgis K, Thomas A, Geyer H, Mareck U, Thevis M. Dietary Supplement and Food Contaminations and Their Implications for Doping Controls. Foods. 2020;9(8):1012. doi: https://doi.org/10.3390/foods9081012

Esposito G, Sciuto S, Martello E, Pezzolato M, Bozzetta E. Disclosing frauds in herbal food supplements labeling: a simple lc-ms/ms approach to detect alkaloids and biogenic amines. J Food Prot. 2023;86(10):100152. doi: https://doi.org/10.1016/j.jfp.2023.100152

New Zealand Medicines and Medical Devices Safety Authority. Minutes of the 30th meeting of the Medicines Classification Committee. New Zealand: MEDSAFE; 2003 [cited 2024 Jul 15]. Available from: https://www.medsafe.govt.nz/profs/class/Minutes/2001-2005/mccMin26Nov03.htm.

Downloads

Publicado

28-07-2025

Como Citar

Cepêda, C. M., & Capela, J. P. (2025). Riscos dos suplementos alimentares para emagrecer contendo sinefrina e cafeína disponíveis em Portugal. Revista De Nutrição, 38. Recuperado de https://periodicos.puc-campinas.edu.br/nutricao/article/view/16560

Edição

Seção

EDUCAÇÃO ALIMENTAR E NUTRICIONAL | THEME SECTION: FOOD AND NUTRITION EDUCATION