Intersexuality· The Reasons For Late Referral To Specialized Service
Keywords:
intersexuality, interdisciplinarity, socio-economic standingAbstract
Objective
Genital ambiguity is a medical and social emergency, requiring an agile and accurate diagnosis to define social sex, preferably before civil registration. This function has been performed by the Interdisciplinary Group for the Study of Sex Determination and Differentiation, at the State University of Campinas, since its creation in 1989. Thus, this research aims to evaluate the characteristics of patients with genital ambiguity in the first consultation at the Interdisciplinary Group of Sex Studies of Sex Determination and Differentiation.
Methods
Retrospective analysis of 254 cases of genital ambiguity treated at the Interdisciplinary Group for the Study of Sex Determination and Differentiation, from January 1989 to December 2001, with identification, socioeconomic and physical examination data on the external genitalia.
Results
The predominant age group was over 1 year of age at the first consultation in the Interdisciplinary Group for the Study of Sex Determination and Differentiation, with only 10% being less than 1 month of age. Of the children (78%), their social sex was previously defined, 52% being male and 26% female. Around 60% of families received less than 1 minimum wage per capita income; and 50% of mothers had less than 4 years of education. Around 45% of children had external genitalia with Prader grades 3 and 4 and more than 50% of cases had both gonads palpable, partly justifying the preference for the social sex previously defined as male.
Conclusion
One of the current priorities of the Interdisciplinary Group for Studies on Sex Determination and Differentiation is the dissemination of these data, especially to pediatricians and neonatologists, with the aim of raising awareness of the early identification of genital ambiguity in children and the need for correct routing of cases.
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References
Pagon RA. Diagnostic approach to the newborn with ambiguous genitalia. Pediatr Clin North Am 1987; 34(4):1019-31.
Grumbach MM. Abnormalities of sex determination and differentiation. ln: Rudolph AM, Hoffan JIE, Rudolph CD, editors. Rudolph's pediatrics. Norwalk: Appletos & Lange; 1996. p. 1773-89.
Styne DM. The testes: Disorders of sexual differentiation and puberty. ln: Sperling MA, editor. Pediatric endocrinology. Philadelphia: WB. Saunders; 1996. p.423-76.
Witchel SS, Lee PA. Ambiguous genitalia. ln: Sperling MA, editor. Pediatric endocrinology. Philadelphia: WB. Saunders; 1996. p.31-49.
Guerra Júnior G, Maciel-Guerra AT. A determinação e diferenciação sexual normais: atualização. Arq Bras Endocrinol Metab1997; 41(4):191-7.
Maciel-Guerra AT, Guerra Júnior G. Menino ou menina? Os distúrbios da diferenciação do sexo. São Paulo: Manole; 2002.
Guerra Júnior G, Maciel-Guerra AT. Classificação dos distúrbios da diferenciação do sexo: os conhecimentos em constante renovação. Rev Fac Cienc Med UNICAMP 1999; 7(1): 103-24.
Baker SW Psychosexual differentiation in the human. Biol Reprod 1980; 22(1):61-72
Money J. Psychologic evaluation of the child with intersex problems. Pediatrics 1965; 36:51-65.
Guerra Júnior G. Atendimento interdisciplinar: análise da resolução de 163 casos de ambigüidade genital no Hospital das Clínicas da Universidade Estadual de Campinas de 1989 a 1995 [doutorado]. Campinas Faculdade de Ciências Médicas, Universidade Estadual de Campinas; 1997.
Danish RK. lntersex problems in the neonate. lndian J Pediatr 1982; 49(399):555-75.
Prader A. Der genital befund bein pseudohermaphroditismus femininus deskongenitalen adrenogenitalen syndrome. Helv Paediatr Acta 1954; 9(3):231-48.
Zucker KJ. lntersexuality and gender identity differentiation. Ann Rev Sex Res 1999; 1 O: 1-69.
Zucker KJ. Evaluation of sex - and gender-assignment decisions in patients with physical intersex conditions: a methodological and statistical note. J Sex Marital Ther 2002; 28(3):269-74.
Krob G, Braun A, Kuhnle U. True hermaphroditism: geographical distri bution, clinicai findings, chromosomes and gonadal histology. Eur J Pediatr 1994; 153(1):2-10.
Quigley C, De Belli A, Marschke KB, EI-Awady M, Wilson EM, French FS. Androgen receptor defects: historical, clinicai, and molecular perspectives. Endocr Rev 1995; 16(3):271-321.
Wilson JD, Griffen JE, Russell DW Steroid 5a-reductase 2 deficiency. Endocr Rev 1993; 14(5):577-93.
Miller WL, Levine LS. Molecular and clinicai advances in congenital adrenal hyperplasia. J Pediatr 1987; 111(1):1-17.
Damiani D. Anomalias da diferenciação sexual. ln: Setian N, editor. Endocrinologia pediátrica: aspectos físicos e metabólicos do recém-nascido ao adolescente. Rio de Janeiro: Guanabara Koogan; 1989. p.341-82.