Changes in laboratory parameters in patients with COVID-19
a systematic review
DOI:
https://doi.org/10.24220/2318-0897v31e2022a5379Keywords:
Biomarkers, Covid-19, Laboratory diagnosisAbstract
The objective of this study was to identify and gather the main findings available at the beginning of the pandemic, regarding laboratory alterations of hospitalized patients with COVID-19 and to discuss the predominance of these alterations in the severity of the course of the disease. This is a systematic literature review, restricted to publications until April 2020, using the Lilacs and Pubmed databases. A total of 381 publications were found in the consulted databases and of these, 17 publications were eligible for analysis according to the inclusion and exclusion criteria. Laboratory parameters such as the reduction of lymphocytes and the elevation of D-dimers, lactate dehydrogenase and C-reactive protein appear to be linked to SARS-CoV-2 infection and may serve as prognostic indicators of the disease. Lymphocytopenia and increased D-dimers are markers related to disease worsening and unfavorable outcomes such as death.
Downloads
References
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020[citado 2020 April 30];382(18):1708-20. Disponível em: https://www.nejm.org/doi/10.1056/NEJMoa2002032
World Health Organization. Coronavirus Disease Pandemia. Geneva: World Health Organization; 2020[citado 2020 May 20]. Disponível em: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
Johns Hopkins University. Coronavirus Resource Center. 2021[citado 2022 Fev 28]. Disponível em: https://coronavirus. jhu.edu/map.html
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. J Am Med Assoc. 2020[citado 2020 Jul. 10];324(8):782-93. Disponível em: https://jamanetwork.com/journals/jama/fullarticle/2768391
Santos C, Pimenta C, Nobre M. A estratégica PICO para a construção da pergunta de pesquisa e busca de evidências. Rev Latino-am Enferm. 2007;15(3):2-5. https://doi.org/10.1590/S0104-11692007000300023
Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368(1091):1-12. https://doi.org/10.1136/bmj.m1091
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. https://doi.org/10.1016/ S0140-6736(20)30566-3
Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, et al. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. E Clinical Med. 2020;21:100331. https://doi.org/10.1016/j. eclinm.2020.100331
Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al. Clinical features and treatment of COVID-19 patients in northeast Chongqing. J Med Virol. 2020;92(7):797-806. https://doi.org/10.1002/jmv.25783
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020;28(71):762-8. https://doi.org/10.1093/cid/ciaa248
Zheng F, Tang W, Li H, Huang YX, Xie YL, Zhou ZG. Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur Rev Med Pharmacol Sci. 2020[citado 2020 Maio 24];24(6):3404-10. Disponível em: https://www.europeanreview.org/article/20711
Wang R, Pan M, Zhang X, Han M, Fan X, Zhao F, et al. Epidemiological and clinical features of 125 Hospitalized Patients with COVID-19 in Fuyang, Anhui, China. Int J Infect Dis. 2020;95:421-8. https://doi.org/10.1016/j.ijid.2020.03.070
Tu WJ, Cao J, Yu L, Hu X, Liu Q. Clinicolaboratory study of 25 fatal cases of COVID-19 in Wuhan. Intensive Care Med. 2020;46(6):1117-20. https://doi.org/10.1007/s00134-020-06023-4
Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan: A retrospective observational study. Am J Respir Crit Care Med. 2020;201(11):1372-9. https://doi.org/10.1164/rccm.202003-0543OC
Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ. 2020[citado 2020 junho 15];368(m606):1-7. https://www.bmj.com/content/368/bmj.m606
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. https://doi. org/10.1016/S0140-6736(20)30211-7
Zhang G, Zhang J, Wang B, Zhu X, Wang Q, Qiu S. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis. Respir Res. 2020[citado 2020 Maio 25];21(74):1-10. Disponível em: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01338-8
Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical Characteristics of Covid-19 in New York City. N Engl J Med. 2020[citado 2020 Maio 30];100(1):1-3. Disponível em: https://www.nejm.org/doi/full/10.1056/ NEJMc2010419
Li R, Tian J, Yang F, Lv L, Yu J, Sun G, et al. Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China. J Clin Virol. 2020;127(104363):1-3. https://doi.org/10.1016/j.jcv.2020.104363
Wang X, Liu W, Zhao J, Lu Y, Yu C, Hu S, et al. Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. J Hosp Infect. 2020;105(3):399-403. https://doi.org/10.1016/j.jhin.2020.04.019
Kazemi E, Soldoozi Nejat R, Ashkan F, Sheibani H. The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis. Ann Clin Microbiol Antimicrob. 2021;20(1):1-12. https://doi.org/10.1186/s12941-021-00420-3
Teimury A, Khameneh MT, Khaledi EM. Major coagulation disorders and parameters in COVID-19 patients. Eur J Med Res. 2022;27(1):1-10. https://doi.org/10.1186/s40001-022-00655-6
Khamis AH, Jaber M, Azar A, Al Qahtani F, Bishawi K, Shanably A. Clinical and laboratory findings of COVID-19: a systematic review and meta-analysis. J Formos Med Assoc. 2021;120(9):1706-18. https://doi.org/10.1016/j.jfma.2020.12.003
Pink I, Raupach D, Fuge J, Vonberg RP, Hoeper MM, Welte T, et al. C-reactive protein and procalcitonin for antimicrobial stewardship in COVID-19. Infection. 2021;49(5):935-43. https://doi.org/10.1007/s15010-021-01615-8
Gorog DA, Storey RF, Gurbel PA, Tantry US, Berger JS, Chan MY, et al. Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium. Nat Rev Cardiol. 2022 [citado 2020 Fev 20];19:475-95. Disponivel em: https://www.nature.com/articles/s41569-021-00665-7
Pecly IMD, Azevedo RB, Muxfeldt ES, Botelho BG, Albuquerque GG, Silva R, et al. A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results. J Bras Nefrol. 2021;43(4):551-71. https://doi.org/10.1590/2175- 8239-JBN-2020-0204
