Favorable prognostic factors in patients with glioblastoma
DOI:
https://doi.org/10.24220/2318-0897v23n1a2414Keywords:
Glioblastoma, Review literature as topic, PrognosisAbstract
This review aims to identify protective factors that contribute to a favorable prognosis in patients with glioblastoma, and thereby provide data to best manage these patients. This is a systematic review of scientific articles published in the last nine years indexed in the databases PubMed and Web of Science, using the keywords “glioblastoma and prognostic factors", Twenty-three articles met the inclusion criteria for the review.
The most studied variables were age, preoperaüve Karnofsky Performance Scale, surgícal treatment, adjuvant therapy, extent of disease, and molecular/genetíc changes.
Tumor clinical, genetic, and treatment aspects proved to be important for a better prognosis, Patients with the best prognosis are young, have the best preoperative
Kamofsky Performance Scale, have a single unilateral tumor, are treated with surgical resectÊon, radiotherapy, and chemotherapy (even older people); and have favorable
molecular/genetic features (high N-myc downstream-regulated gene-1 expression in glioma compared with normal brain tissues; hypermethylation of 06-metilguaninametiltransferase
gene; lsocitrate Dehydrogenase-1 mutation; and absence of Single-
Stranded Deoxyribonudeic Acid-Binding Protein-2 expression).
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