APOPTOSIS
THE IMPORTANCE OF CELL DEATH MACHINERY IN DISEASE CONTROL AND PATHOGENESIS
Keywords:
cell death, communicable diseases, chronic-degenerative diseases, apoptosisAbstract
The main molecular and cellular events involved in the genesis of programmed cell death were reviewed. The major genes and its regulatory proteins (Ceds, Caspases, CPP32, Bcl-x, Bad, Bax, V-abl, APC, Apaf-l, Ich-l), as well as the role of some growth factors (NGF, IGF), hormones, interleucines, and injury agents (excitotoxic neurotransmitters, oxygen free radicals, xenobiotics, metals and particulate materials) on triggering off the cell death programs, were described. Besides, the main inhibiting or stimulating apoptotic pathways were related. Finally, a great number of physiopathological conditions associated with diminishing or increasing tissues cellular suicide rates were also described. So, the knowledge of apoptotic regulatory mechanisms is essential to the efficient control and prevention of many diseases.
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