"EFFECT OF NALIDIXIC ACID ON RATS"
Keywords:
nalidixic acid, histological studies and pathological studiesAbstract
Sprague-Dawley rats of both sexes received daily by way of gastric intubation (na/idixic acid for each 10 g of body weight). After 30, 60 and 75 days of nalidixic acid administration, the animais were sacrifled and their lungs, spleen, brain, heart, liver and kidneys, were removed.
The histopathologic exam of these organs indicates necrosis and hemodinamic alterations that occured with more frequency and intensity in the lungs, li ver, heart and kidneys.
Most of these changes were a consequence of the toxic ejfects of nalidixic acid it follows that caution is necessary when this drug is prescribed for people taking into consideration principally the dosage.
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References
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