Return to Article Details The painful vaso-occlusive crisis is the most common event and principal cause of sickle cell disease morbidity, as well as the most frequent reason for seeking emergency care and hospital admission. This study aimed to assess the índications, doses, administration routes and side effects of analgesics recommended to treat painful crises in children. A literature search was done in the Medline, SciELO, Lilacs and PubMed databases using the following keywords: anemia, sickle cell, analgesia. pain and child. Analysis of the literature reveafed that the treatment of painful crisis in children is complex, as it involves the subjectivity of pain, its correct measurement and its restrictíon to medication that is safe and efficient for use in the pediatric population, Treatment protocols exist as general guidelines, as conduct should always be individualized, Successful pain treatment depends on knowíedge of the pathophysiology of painful crisis, pharmacology of analgesics and valuing what the patient is feeling. Physicians should be ready to recognize and treat this complication which has a relevant impact on the quality of life of children with sickle cell disease Download Download PDF